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20,252 grants found
Showing 16,761 – 16,780 of 20,252 grants
Core A - Administration
PROEJCT SUMMARY: CORE A The Administrative Core will provide centralized grant administration, data processing and administrative support for the projects. This Core will also serv...
Core B – Human Biospecimen and Advanced Sequencing Core
PROJECT SUMMARY: CORE B The goal of this Program is to advance knowledge of pancreatic ductal adenocarcinoma (PDAC), a recalcitrant cancer with one of the highest rates of cachexia...
Core C – Immunophenotyping Core
SUMMARY: CORE C Cachexia is a wasting syndrome that significantly contributes to the morbidity and mortality of cancer patients, especially those diagnosed with pancreatic ductal a...
Core D – Biostatistics Core
SUMMARY: CORE D The Biostatistics Core provides centralized and state-of-the-art support to meet the data management and analytic needs of the Program Project Grant. Core personnel...
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms
PROJECT SUMMARY/ABSTRACT Ten Eleven Translocation (TET1, TET2 and TET3) are α-ketoglutarate (αKG) and Fe2+ dependent DNA- dioxygenases that is a key regulator of epigenetic landsca...
Acceptance and Commitment Therapy for Fear of Recurrence in Breast Cancer Survivors
PROJECT SUMMARY / ABSTRACT Following treatment for early-stage cancer, most survivors fear the possibility of a recurrence. While mild and intermittent for many, these fears become...
Understanding the role of TWIST1 in colorectal cancer progression and metastasis
Project Summary: Although almost all colorectal cancer (CRC) mortality is due to metastasis, there are currently no drugs to prevent or halt metastasis. A better understanding of t...
A transcription-independent role of HSF1 in tumorigenesis via suppression of AMPK
Project Summary There is an urgent need to develop new therapeutic options for carcinogenesis. The goal of this proposal is to help fulfill this need by shedding new light on the m...
Biochemical and Mechanistic Insights into the Roles of Rad51 Paralogs in Homologous Recombination Repair
PROJECT SUMMARY/ABSTRACT Understanding the molecular pathways disrupted in breast and ovarian cancer is vital to combating these devastating diseases. Hereditary susceptibility to...
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer. Despite recent successes in immune checkpoint therapy of several human cancer t...
Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
PROJECT SUMMARY The overall goal of the proposed research is to understand the role of Twist1 in cutaneous squamous cell carcinoma (cSCC) and to develop novel approaches for target...
Regulatory T cells in cancer therapy
Project Summary Extensive studies have been conducted to define the development, conversion, stability, and regulatory mechanisms of CD4+Foxp3+ regulatory T cells (Tregs) in homeos...
Dynamic prediction incorporating time-varying covariates for the onset of breast cancer
PROJECT SUMMARY Accurate assessment of risk is a top priority in oncology due to the population burden of cancer. Breast cancer is the leading cancer diagnosis among women worldwid...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using pati...
Vascularized tumor explants for drug testing
Project Abstract Our understanding of cancer progression or response to therapies would benefit from easily accessible, patient- specific assays that recapitulate the biology and a...
The Effect of Tumor Burden on Peripheral cDC1 Activation and Functionality
PROJECT SUMMARY/ABSTRACT Tumors disrupt the homeostasis of the immune system, altering immune cell composition and phenotype in the tumor microenvironment (TME), lymph nodes, splee...
UCSF Paul Calabresi K12 Career Development Program in Clinical Oncology
Project Summary/Abstract The goal of the UCSF Paul Calabresi Career Development Award for Clinical Oncology is to foster the development of the next generation of clinical scientis...
RNA Methylation in Cancer Plasticity and Drug Resistance
PROJECT SUMMARY/ ABSTRACT Cancer drug resistance occurs not only by selection of genetically resistant clones, but also through phenotypic plasticity via rapid induction of transcr...
Mechanisms of DNMT3B-mediated DNA Methylation Maintenance
PROJECT SUMMARY DNA methylation (5mC) is catalyzed by three DNA methyltransferases (DNMTs): DNMT1, DNMT3A, and DNMT3B. DNMT3A and 3B are often referred to as de novo DNMTs, functio...
Integrated ligand and target discovery by chemical proteomics for glioblastoma treatment.
PROJECT SUMMARY The epidermal growth factor (EGFR) oncogene is amplified and drives tumor growth in 55% of adult glioblastomas (GBMs). However, EGFR inhibitors have failed to demon...