Browse All Grants
20,252 grants found
Showing 16,741 – 16,760 of 20,252 grants
PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy
SUMMARY. The problem: Hormone therapy remains the standard treatment for prostate cancer (PC). While most patients initially respond to therapy, they will ultimately progress to le...
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
Project Summary Poor diet and excess weight during adolescence predicts excess weight and diet-related cancers during adulthood, yet there is little research on the risk factors th...
Development of AMPK Inhibitors for the treatment of leukemia
PROJECT SUMMARY Despite advances in the treatment of acute myeloid leukemia (AML), only 20–30% of patients achieve long-term disease-free survival (DFS) and treatment options for r...
Plk1 as a prognostic biomarker for prostate cancer
Title: Plk1 as a prognostic biomarker for prostate cancer Abstract Because androgen receptor (AR) signaling is essential for development of prostate cancer (PCa), including castrat...
Mechanisms of Hedgehog signaling in glioblastoma
Project summary Glioblastomas are deadly tumors and account for approximately half of all malignant primary brain cancers. Glioblastoma stem cells exist in interchangeable cellular...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
The supplement instructions PA-21-071 state: “At minimum, the Research Strategy section should be completed and must include a summary or abstract of the funded parent award or pro...
Investigating cells of origin and oncogenic modifiers of 3q26-driven LUSC
Project Abstract Lung squamous cell carcinoma (LUSC) is a major subtype of lung cancer accounting for ~30% of all lung cancer diagnoses. LUSC patients suffer from poor therapeutic...
Neural Niche in Promoting Brain Metastatic Tumor Progression
Project Summary Title: Neural Niche in Promoting Brain Metastasis Progression Metastatic progression at the brain is a multi-step, evolutionary process that is accomplished through...
Improving the Timeliness and Quality of Care for Rural Lung and Head-and-Neck Cancer Patients
ABSTRACT: Improving the timeliness and quality of care for lung cancer (LC) and head and neck cancer (HNC) patients is of utmost importance because delays in treatment initiation a...
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
Late stage ovarian cancer is marked by poor patient survival and significant metastatic spread throughout the peritoneal cavity. During transcoelomic spread cells must adapt to sur...
MyGI Diet for Colorectal Cancer Prevention
Project Summary This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA 21-070. The parent grant tests methods to assist high...
The regulation of mutant p53 protein accumulation in cancer: molecular basis and therapeutic potential
Abstract Tumor suppressor p53 is the most frequently mutated gene in human cancer, including colorectal cancer (CRC). Many tumor-associated mutant p53 (mutp53) proteins not only lo...
Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas
Project Summary/Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous and poorly understood pathological group of non-Hodgkin lymphomas associated with poor progno...
Regional selectivity of oncohistone H3K27M on glial development and glioma pathogenesis
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an incurable high-grade glioma arising in the brainstem primarily in younger children. DIPG 2-year survival rate is
Elucidating the molecular mechanisms of PRMT5i response and resistance in LUAD and PDAC
Project Summary Protein arginine methyltransferase 5 (PRMT5) is part of a methyltransferase complex that symmetrically dimethylates arginine residues in a wide range of proteins re...
Regulation of DNA replication kinetics by BRCA2 after DNA damage
Germline mutations in BRCA2 predispose carriers to breast, ovarian, pancreatic, and other cancers. The gene encodes a very large protein that plays critical roles in genome integri...
The role of the macroenvironment in pancreatic cancer-induced cachexia
PROJECT SUMMARY: OVERALL The overall goal of this Program Project is to gain a better understanding of the underlying mechanisms that drive cachexia in cancer patients, especially...
Project 1 – IL-6/STAT3/NF-kB in Adipose-Muscle Crosstalk in the Pancreatic Cancer Macroenvironment
PROJECT SUMMARY: PROJECT 1 Cancer cachexia, or progressive weight loss featuring immunodysmetabolism, causes ~1/3 of cancer deaths. Loss of muscle mass reduces performance status,...
Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia
PROJECT SUMMARY: PROJECT 2 Cachexia is a debilitating syndrome that results in severe, involuntary weight loss due to the depletion of skeletal muscle and adipose tissues. This syn...
Project 3 – Stromal derived IL-6/STAT3 signaling in the development and progression of PDAC
PROJECT SUMMARY: PROJECT 3 PDAC is among the most deadly malignant solid tumors, with approximately 92% of patients succumbing to the disease within five years of diagnosis, and wi...