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20,252 grants found
Showing 16,721 – 16,740 of 20,252 grants
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer. Despite recent successes in immune checkpoint therapy of several human cancer t...
Hexokinase 2 and cancer therapy
Cancer cells are metabolically different from normal matching cells, and this is manifested by the high rate of glucose metabolism in cancer cells. The high rate of glucose metabol...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using pati...
Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening
Abstract Esophageal cancer is the 6th leading cause of cancer death worldwide; rates of esophageal adenocarcinoma (EAC) haverisen exponentially over the past 4 decades. When EAC is...
Defining mechanisms of thalidomide analog resistance
PROJECT SUMMARY Thalidomide and its analogs, lenalidomide and pomalidomide, have revolutionized the treatment of patients with multiple myeloma (MM) and other hematologic malignanc...
Integrated ligand and target discovery by chemical proteomics for glioblastoma treatment.
PROJECT SUMMARY The epidermal growth factor (EGFR) oncogene is amplified and drives tumor growth in 55% of adult glioblastomas (GBMs). However, EGFR inhibitors have failed to demon...
Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age
Abstract In recent years, the incidence of colorectal cancer (CRC) under the age of 50-years has increased significantly and population-based screening is currently not offered to...
Metabolic Control and Anticancer Mechanism
ABSTRACT As a central controller of cancer growth and metabolism, mTORC1 pathway is commonly mutated and activated in human cancer, leading to uncontrolled growth. Cancer cells are...
Neural Niche in Promoting Brain Metastatic Tumor Progression
Project Summary Title: Neural Niche in Promoting Brain Metastasis Progression Metastatic progression at the brain is a multi-step, evolutionary process that is accomplished through...
High-Throughput Screen for the Oncoprotein MYC
ABSTRACT MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apop...
Germline and Somatic Genomic Studies in CLL Minorities
African Americans are significantly underrepresented in cancer research. Although there have been recent efforts toward more inclusion of African Americans in cancer research, subs...
Epigenetically Engineered Mouse Model for Lung Cancer Therapy
PROJECT SUMMARY (Abstract) The importance of aberrant DNA methylation in cancer is clear. The fundamental role of DNA methylation in cancer initiation and progression, however, rem...
Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy
PROJECT SUMMARY Osteosarcoma (OS) is the most common malignant bone tumor, found in the pediatric population and often leads to death due to tumor progression and metastasis. Despi...
Genetic dissection of oncogenic Kras signaling
ABSTRACT Lung cancer is a prevalent cancer type that leads to more deaths than the next four major cancer types combined. KRAS is one of the most frequent oncogenes in human lung c...
Using dietary glutamine supplementation for melanoma prevention and targeted therapy
PROJECT SUMMARY Despite recent advances in cancer metabolism, whether and how nutritional interventions affect tumor development, metastasis and therapeutic response are still poor...
Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors
PROJECT SUMMARY Despite the known roles of chromatin remodeling complexes in driving more than 20% of human cancer, the role of chromatin remodeling complexes in conferring therape...
Regulation of DNA replication kinetics by BRCA2 after DNA damage
Germline mutations in BRCA2 predispose carriers to breast, ovarian, pancreatic, and other cancers. The gene encodes a very large protein that plays critical roles in genome integri...
VDX-111: A novel targeted therapeutic for triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancers (TNBC) represent a significant challenge to basic scientists studying the molecular underpinnings of the disease and to patients and...
Developing novel bispecific antibodies for cancer treatment
PROJECT SUMMARY The overall goal of this project is to improve activities of therapeutic antibodies against cancer metastasis through developing novel bispecific antibodies (BsAbs)...