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20,252 grants found
Showing 16,701 – 16,720 of 20,252 grants
NCI Pediatric In Vivo Testing Program: Neuroblastoma
Project Summary Children with disseminated neuroblastoma have a very high risk of treatment failure and death despite receiving intensified chemotherapy, radiation therapy and immu...
A Genetically Tractable Mouse Model for PRKCI-driven Lung Squamous Cell Carcinoma
Project Abstract Lung cancer is the number one cause of cancer death in the United States. Non-small cell lung cancer (NSCLC), which accounts for the majority (80%) of lung cancer...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Urine based circulating tumor DNA analysis
ABSTRACT Urine is an underappreciated source for systemic circulating tumor DNA in patients with non-genitourinary cancers. Based on recent data suggesting that blood-based HPV DNA...
Regulatory T cells in cancer therapy
Project Summary Extensive studies have been conducted to define the development, conversion, stability, and regulatory mechanisms of CD4+Foxp3+ regulatory T cells (Tregs) in homeos...
Dynamic prediction incorporating time-varying covariates for the onset of breast cancer
PROJECT SUMMARY Accurate assessment of risk is a top priority in oncology due to the population burden of cancer. Breast cancer is the leading cancer diagnosis among women worldwid...
Investigating apoptotic priming as a determinant of sensitivity to leukemia-directed therapies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a clonal expansion of precursor blood- forming cells. Intensive chemotherapy has bee...
Acceptance and Commitment Therapy for Fear of Recurrence in Breast Cancer Survivors
PROJECT SUMMARY / ABSTRACT Following treatment for early-stage cancer, most survivors fear the possibility of a recurrence. While mild and intermittent for many, these fears become...
Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis
PROJECT SUMMARY/ABSTRACT As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the United States. Although low...
The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment
Abstract Glioblastoma (GB) is the most common primary tumor of the central nervous system (CNS) in adults. Despite aggressive surgery, radiation, and chemotherapy, median survival...
Impact of Host NF-kB Signaling in Radiation Therapy
PROJECT SUMMARY / ABSTRACT Investigation of cytoplasmic-to-nuclear (C→N) NF-κB signaling pathways induced by various cell surface receptors has significantly expanded the knowledge...
Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma
Project Summary/Abstract Programmed cell death 1 (PD-1) and its ligands, PD-L1 and PD-L2, are highly expressed in human and murine thymus. Despite this knowledge, the function of t...
Androgen Signaling in CaP with loss of MAP3K7 and CHD1
Prostate cancer is characterized by large genomic rearrangements and deletions. We show that the genes CHD1 and MAP3K7 are co-deleted in ERG translocation negative prostate cancer....
Improving pediatric brain tumor treatments using FLASH radiotherapy
PROJECT SUMMARY Our R01 application entitled, “Improving pediatric brain tumor treatments using FLASH radiotherapy” is focused on translating a novel irradiation modality into clin...
In vivo characterization of keratinocytes in the melanoma microenvironment
PROJECT SUMMARY Melanoma is the most lethal of skin cancers, with progression to local invasion and metastasis leading to poor patient outcomes, highlighting the need for better un...
Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children, with T-cell ALL accounting for 15% of cases. T-ALL in children is associated with aggressive clin...
Novel DNA damage response therapeutics targeting replication protein A
Novel DNA damage response therapeutics targeting replication protein A Abstract The DNA damage response (DDR) is now considered a tractable pathway to target for cancer therapy. Th...
A pro-metastatic secretory pathway activated by p53 loss in lung cancer
Cancer cells are embedded in a protective and nourishing “niche”, an environment that cancer cells create by secreting proteins into their surroundings. Because cancer cells depend...
Rational in situ programming of cancer vaccine-responding T-cell clones
Project Summary Currently no method exists that would allow physicians to rapidly and reliably establish T-cell immunity against tumor antigens. Bioinformatics tools can predict an...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...