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20,252 grants found
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Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
PROJECT SUMMARY Pancreatic cancer is a major health issue in the US, with only 7% of patients surviving beyond 5-years and nearly all patients presenting with metastases. Identifyi...
Targeting cellular double-stranded RNA homeostasis in breast cancer
Summary/Abstract The immunologically inactive (cold) tumor is a major challenge for effective immunotherapies in many cancers, including breast cancer. Increasing evidence has demo...
Metabolite sensing through the HAT1 acetyltransferase as an anti-cancer target
PROJECT SUMMARY/ABSTRACT This is an application for a K08 for Dr. Joshua Gruber, an Instructor of Medicine at Stanford University. Dr. Gruber wishes to establish himself as a clini...
Mechanisms of DNMT3B-mediated DNA Methylation Maintenance
PROJECT SUMMARY DNA methylation (5mC) is catalyzed by three DNA methyltransferases (DNMTs): DNMT1, DNMT3A, and DNMT3B. DNMT3A and 3B are often referred to as de novo DNMTs, functio...
Decoding Individual Exosomes in Cancer
PROJECT SUMMARY There is increasing recognition that extracellular vesicles (EVs)¾micrometer- or nanometer-sized lipid particles containing protein and nucleic acid cargoes (inform...
Function of Musashi-2 Methylation in Normal and Malignant Hematopoiesis
Project Abstract Acute myeloid leukemia (AML) is an aggressive, heterogeneous disease and is characterized by the expansion of immature myeloid progenitors and the inhibition of my...
Infection-Associated Cancer Research Training Program in Mali
PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research T...
Mechanisms associated with organotropic metastasis
ABSTRACT Most cancer patients with solid tumors die of metastatic disease and organotropic spread is an understudied aspect of metastasis, for which new insights are urgently requi...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
Late stage ovarian cancer is marked by poor patient survival and significant metastatic spread throughout the peritoneal cavity. During transcoelomic spread cells must adapt to sur...
Mechanisms of Hedgehog signaling in glioblastoma
Project summary Glioblastomas are deadly tumors and account for approximately half of all malignant primary brain cancers. Glioblastoma stem cells exist in interchangeable cellular...
Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas
Project Summary/Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous and poorly understood pathological group of non-Hodgkin lymphomas associated with poor progno...
Understanding the role of TWIST1 in colorectal cancer progression and metastasis
Project Summary: Although almost all colorectal cancer (CRC) mortality is due to metastasis, there are currently no drugs to prevent or halt metastasis. A better understanding of t...
Real time colon histopathology by infrared spectroscopic imaging
Abstract Colorectal cancer (CRC) is one of the leading causes of death in the US. Active screening and early intervention in risky cancers can lead to good outcomes; however, a bot...
The RNA structural code underlying pathological regulation of RNA splicing in metastasis
PROJECT SUMMARY Widespread aberrant splicing is now considered a hallmark of cancer, and many of the resulting transcript isoforms have been functionally implicated in tumorigenesi...
RNase H2 is a novel therapeutic target in triple negative breast cancer
Project Summary Due to their hyperproliferative nature and intrinsic genomic instability, triple-negative breast cancer (TNBC) cells exhibit high levels of replication stress, whic...
Prognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for Cancer
Adoptive cellular therapy (ACT) has revolutionized the treatment of certain malignancies and responses in refractory B cell tumors treated with chimeric antibody receptor (CAR)-exp...
Targeting cellular double-stranded RNA homeostasis in breast cancer
Summary/Abstract The immunologically inactive (cold) tumor is a major challenge for effective immunotherapies in many cancers, including breast cancer. Increasing evidence has demo...
Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients
Project Summary/Abstract The goal of this research project is to investigate new 3D advanced hyperpolarized (HP) 13C-pyruvate MRI techniques to quantitatively monitor metabolic cha...
Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
Project Summary/Abstract: The introduction of multi-gene panel testing for hereditary breast and ovarian cancer (HBOC) syndrome has rapidly changed the clinical approach to genetic...