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20,252 grants found
Showing 16,661 – 16,680 of 20,252 grants
Core C – Immunophenotyping Core
SUMMARY: CORE C Cachexia is a wasting syndrome that significantly contributes to the morbidity and mortality of cancer patients, especially those diagnosed with pancreatic ductal a...
Core D – Biostatistics Core
SUMMARY: CORE D The Biostatistics Core provides centralized and state-of-the-art support to meet the data management and analytic needs of the Program Project Grant. Core personnel...
The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment
Abstract Glioblastoma (GB) is the most common primary tumor of the central nervous system (CNS) in adults. Despite aggressive surgery, radiation, and chemotherapy, median survival...
Targeting CD133 for imaging and therapy in prostate cancer
ABSTRACT Aggressive variant prostate cancer (AVPC) arises in men who have failed treatment with second-generation anti-androgen therapy. Not driven by the androgen receptor-signali...
Persistent STAT5 signaling in polyfunctional CD4 T cells and its application in adoptive T cell therapy
Project summary/abstract Recent advances in adoptive T-cell therapy (ACT), especially CD19-targeting chimeric antigen receptor (CAR) T-cell therapy (CD19CART), have highlighted the...
Developing novel bispecific antibodies for cancer treatment
PROJECT SUMMARY The overall goal of this project is to improve activities of therapeutic antibodies against cancer metastasis through developing novel bispecific antibodies (BsAbs)...
Acceptance and Commitment Therapy for Fear of Recurrence in Breast Cancer Survivors
PROJECT SUMMARY / ABSTRACT Following treatment for early-stage cancer, most survivors fear the possibility of a recurrence. While mild and intermittent for many, these fears become...
3D Ultra-sensitive Ultrasound Microvessel Imaging for Breast Mass Differentiation
PROJECT SUMMARY Breast cancer, the second-leading cause of cancer deaths among women, affects millions of Americans. Early cancer detection and accurate tumor diagnosis are crucial...
State-of-the-Art Synthesis of Interventions to Promote Quit Intentions and Smoking Cessation
Project Summary Most people who smoke have no intention of quitting in the next 6 months or beyond, which begs critical questions of the field of cancer prevention and control: How...
In vivo characterization of keratinocytes in the melanoma microenvironment
PROJECT SUMMARY Melanoma is the most lethal of skin cancers, with progression to local invasion and metastasis leading to poor patient outcomes, highlighting the need for better un...
Biochemical and Mechanistic Insights into the Roles of Rad51 Paralogs in Homologous Recombination Repair
PROJECT SUMMARY/ABSTRACT Understanding the molecular pathways disrupted in breast and ovarian cancer is vital to combating these devastating diseases. Hereditary susceptibility to...
RNA Methylation in Cancer Plasticity and Drug Resistance
PROJECT SUMMARY/ ABSTRACT Cancer drug resistance occurs not only by selection of genetically resistant clones, but also through phenotypic plasticity via rapid induction of transcr...
Urine based circulating tumor DNA analysis
Urine is an underappreciated source for systemic circulating tumor DNA in patients with non-genitourinary cancers. Based on recent data suggesting that blood-based HPV DNA testing...
Ovarian Inflammaging as a Mechanism for Ovarian Cancer
PROJECT SUMMARY High-grade serous ovarian carcinoma (HGSOC) is the most lethal cancer of the female reproductive system with less than 50% of patients surviving 5-years after diagn...
Mechanisms associated with organotropic metastasis
ABSTRACT Most cancer patients with solid tumors die of metastatic disease and organotropic spread is an understudied aspect of metastasis, for which new insights are urgently requi...
Short Chain Fatty Acids: Route for Facilitation of Oral HPV via Inflammasome Dysregulation in People Living with HIV
PROJECT SUMMARY/ABSTRACT The oral microbiota and inflammasome protein complex are essential factors for maintaining immune homeostasis, which are altered by an HIV infection and ha...
Regional selectivity of oncohistone H3K27M on glial development and glioma pathogenesis
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an incurable high-grade glioma arising in the brainstem primarily in younger children. DIPG 2-year survival rate is
The role of an invasive phenotype in promoting resistance to MAPK-directed therapies in thyroid cancer
Thyroid cancer is the most common endocrine malignancy, accounting for over 52,000 new diagnoses each year.Advanced papillary thyroid cancer (PTC) and anaplastic thyroid cancer (AT...
The role of CEACAM1 in oncogenic B-cell receptor signaling and immunotherapy in mantle cell lymphoma
Abstract Mantle cell lymphoma (MCL) accounts for 6-8% of all non-Hodgkin lymphomas (NHLs). While substantial therapeutic advances have been achieved for other NHLs, MCL remains an...
Genetic dissection of oncogenic Kras signaling
ABSTRACT Lung cancer is a prevalent cancer type that leads to more deaths than the next four major cancer types combined. KRAS is one of the most frequent oncogenes in human lung c...