Browse All Grants
20,252 grants found
Showing 16,641 – 16,660 of 20,252 grants
Dissecting the Execution Phase of BAK-Mediated Apoptosis in Cancer
PROJECT SUMMARY BCL-2 family proteins are critical regulators of apoptosis and deregulation of their protein interactions contributes to the development and chemoresistance of canc...
A DUAL ROLE OF INTEGRIN ALPHA-3 IN BREAST CANCER CNS METASTASIS & CHEMORESISTANCE
ABSTRACT Integrins serve a multifaceted role in cancer progression by regulating cell migration as well as mediating signaling pathways important in proliferation and chemoresistan...
Platelet PI3Kbeta regulation of metastasis
Abstract Metastasis is the primary cause of morbidity and mortality among patients with solid tumors. Platelets interact with tumor cells upon their entry into the vasculature and...
Dynamic µOCT for cellular tissue phenotyping
Phenotyping cells and tissue is a critical function that spans basic science to clinical diagnosis. Yet, established methods for phenotyping cells in tissue are static, are evaluat...
Adoptive Cellular Therapy of T Cell Lymphoma
PROJECT SUMMARY Peripheral T cell lymphomas (PTCL) are a highly heterogeneous group of neoplasms that account for 10-30% of all Non-Hodgkin Lymphomas. Of these, angioimmunoblastic...
The Effect of Tumor Burden on Peripheral cDC1 Activation and Functionality
PROJECT SUMMARY/ABSTRACT Tumors disrupt the homeostasis of the immune system, altering immune cell composition and phenotype in the tumor microenvironment (TME), lymph nodes, splee...
Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis
PROJECT SUMMARY/ABSTRACT As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the United States. Although low...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using pati...
Urine based circulating tumor DNA analysis
ABSTRACT Urine is an underappreciated source for systemic circulating tumor DNA in patients with non-genitourinary cancers. Based on recent data suggesting that blood-based HPV DNA...
Development of a clinically relevant mouse model of ER+ breast cancer
The purpose of this proposed R21 project is to develop and validate a novel, clinically relevant mouse model for estrogen receptor-positive (ER+) breast cancer. Most human breast c...
Defining mechanisms of thalidomide analog resistance
PROJECT SUMMARY Thalidomide and its analogs, lenalidomide and pomalidomide, have revolutionized the treatment of patients with multiple myeloma (MM) and other hematologic malignanc...
Remote monitoring of cardiac function in childhood cancer survivors
Abstract Cardiovascular complications are a leading cause of morbidity and mortality in survivors of childhood cancer. These survivors have a greater than four-fold risk of develop...
Decoding the Tissue of Origin of Cellular Damage from Cell-free DNA in Liquid Biopsies
ABSTRACT Liquid biopsy applications are rapidly emerging as a minimally invasive approach to collect system-wide representative analytes for genomic monitoring of physiologic and d...
The role of the macroenvironment in pancreatic cancer-induced cachexia
PROJECT SUMMARY: OVERALL The overall goal of this Program Project is to gain a better understanding of the underlying mechanisms that drive cachexia in cancer patients, especially...
Project 1 – IL-6/STAT3/NF-kB in Adipose-Muscle Crosstalk in the Pancreatic Cancer Macroenvironment
PROJECT SUMMARY: PROJECT 1 Cancer cachexia, or progressive weight loss featuring immunodysmetabolism, causes ~1/3 of cancer deaths. Loss of muscle mass reduces performance status,...
Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia
PROJECT SUMMARY: PROJECT 2 Cachexia is a debilitating syndrome that results in severe, involuntary weight loss due to the depletion of skeletal muscle and adipose tissues. This syn...
Project 3 – Stromal derived IL-6/STAT3 signaling in the development and progression of PDAC
PROJECT SUMMARY: PROJECT 3 PDAC is among the most deadly malignant solid tumors, with approximately 92% of patients succumbing to the disease within five years of diagnosis, and wi...
Core A - Administration
PROEJCT SUMMARY: CORE A The Administrative Core will provide centralized grant administration, data processing and administrative support for the projects. This Core will also serv...
Core B – Human Biospecimen and Advanced Sequencing Core
PROJECT SUMMARY: CORE B The goal of this Program is to advance knowledge of pancreatic ductal adenocarcinoma (PDAC), a recalcitrant cancer with one of the highest rates of cachexia...