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20,252 grants found
Showing 16,601 – 16,620 of 20,252 grants
Ultra-sensitive Singlet Oxygen Dosimeter for Skin Cancer Treatment and Prevention
Project Summary/Abstract Skin cancer is the most common form of cancer. Each year in the U.S. alone over 5.4 million cases of nonmelanoma skin cancer are treated. The annual cost o...
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Regulatory T cells in cancer therapy
Project Summary Extensive studies have been conducted to define the development, conversion, stability, and regulatory mechanisms of CD4+Foxp3+ regulatory T cells (Tregs) in homeos...
Statistical methods for cancer progression delineation and subtype identification
Project Summary Carcinogenesis is a complex process involving somatic mutations in a number of key biological pathways and processes. Full study of the temporal order of somatic mu...
Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The development of targeted molecular therapies that inhibit m...
Prognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for Cancer
Adoptive cellular therapy (ACT) has revolutionized the treatment of certain malignancies and responses in refractory B cell tumors treated with chimeric antibody receptor (CAR)-exp...
Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
PROJECT SUMMARY The overall goal of the proposed research is to understand the role of Twist1 in cutaneous squamous cell carcinoma (cSCC) and to develop novel approaches for target...
Vascularized tumor explants for drug testing
Project Abstract Our understanding of cancer progression or response to therapies would benefit from easily accessible, patient- specific assays that recapitulate the biology and a...
Rational in situ programming of cancer vaccine-responding T-cell clones
Project Summary Currently no method exists that would allow physicians to rapidly and reliably establish T-cell immunity against tumor antigens. Bioinformatics tools can predict an...
A Genetically Tractable Mouse Model for PRKCI-driven Lung Squamous Cell Carcinoma
Project Abstract Lung cancer is the number one cause of cancer death in the United States. Non-small cell lung cancer (NSCLC), which accounts for the majority (80%) of lung cancer...
Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma
Project Summary/Abstract Programmed cell death 1 (PD-1) and its ligands, PD-L1 and PD-L2, are highly expressed in human and murine thymus. Despite this knowledge, the function of t...
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance
SUMMARY. Kinase inhibitors targeting the catalytic subunit of the DNA-dependent protein kinase (DNAPKcs) are being developed to sensitize tumors to clastogenic (chromosomal-breakin...
Precision magnetic hyperthermia by integrating magnetic particle imaging
Precision magnetic hyperthermia by integrating magnetic particle imaging Magnetic activation of magnetic iron oxide nanoparticles (MIONPs) offers considerable potential for numerou...
Enhancing the efficacy of androgen signaling inhibitors in prostate cancer
Title: Enhancing the efficacy of androgen signaling inhibitors in prostate cancer Abstract It has been documented that androgen receptor (AR) signaling remains to play a critical r...
CONNECT: COmpreheNsive traiNing and Engagement in Cessation Treatment
PROJECT SUMMARY Adult smoking prevalence in the United States (US) is approximately 14% nationwide, yet significant disparities persist, including among adults with annual househol...
Androgen receptor pathway inhibition through targeting PARP-2 in castration-resistant prostate cancer
ABSTRACT Androgen receptor (AR) is ligand-activated transcription factor and a driver of prostate cancer (PCa). Understanding the molecular mechanisms of AR-mediated transcription...
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms
PROJECT SUMMARY/ABSTRACT Ten Eleven Translocation (TET1, TET2 and TET3) are α-ketoglutarate (αKG) and Fe2+ dependent DNA- dioxygenases that is a key regulator of epigenetic landsca...
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
Project Summary Poor diet and excess weight during adolescence predicts excess weight and diet-related cancers during adulthood, yet there is little research on the risk factors th...
Dynamic prediction incorporating time-varying covariates for the onset of breast cancer
PROJECT SUMMARY Accurate assessment of risk is a top priority in oncology due to the population burden of cancer. Breast cancer is the leading cancer diagnosis among women worldwid...
Innate Immune Mechanisms Contributing to Cancer Growth in Obesity
Project Summary/Abstract Colorectal cancer (CRC) is the second leading cause of cancer mortality in the United States, and obesity, which affects 40% of the population, not only in...