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20,252 grants found
Showing 16,581 – 16,600 of 20,252 grants
Novel DNA damage response therapeutics targeting replication protein A
Novel DNA damage response therapeutics targeting replication protein A Abstract The DNA damage response (DDR) is now considered a tractable pathway to target for cancer therapy.The...
RNase H2 is a novel therapeutic target in triple negative breast cancer
Project Summary Due to their hyperproliferative nature and intrinsic genomic instability, triple-negative breast cancer (TNBC) cells exhibit high levels of replication stress, whic...
Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients
Project Summary/Abstract The goal of this research project is to investigate new 3D advanced hyperpolarized (HP) 13C-pyruvate MRI techniques to quantitatively monitor metabolic cha...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer.These models are established using patie...
Inhibiting tumor growth and metastasis in highly aggressive breast cancers with centrosome amplification
PROJECT SUMMARY Centrosome amplification (CA) is highly prevalent in cancer and strongly associated with tumor progression and worse prognosis in several different cancers, includi...
Neural Niche in Promoting Brain Metastatic Tumor Progression
Project Summary Title: Neural Niche in Promoting Brain Metastatic Tumor Progression Metastatic progression at the brain is a multi-step, evolutionary process that is accomplished t...
Ovarian Inflammaging as a Mechanism for Ovarian Cancer
PROJECT SUMMARY High-grade serous ovarian carcinoma (HGSOC) is the most lethal cancer of the female reproductive system with less than 50% of patients surviving 5-years after diagn...
Rewiring of epigenetic DNA damage response pathways in HPV-induced cancer
Project summary/abstract Infection with human papilloma virus (HPV) causes endemic occurrence of cervical, head and neck and anal cancers. Radiotherapy is the cornerstone treatment...
Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities
PROJECT SUMMARY/ABSTRACT Cancer is a common diagnosis in the emergency department (ED) and by the time patients reach the ED, their cancer has often progressed to later stages. EDs...
Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors
ABSTRACT With recent enactment of the Research to Accelerate Cures and Equity (RACE) for Children Act, there is a growing impetus to identify pediatric indications for molecularly...
In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
PROJECT SUMMARY Despite the advances made in our understanding of the etiology of pediatric soft tissue sarcomas (STS), the overall survival of those diseases has not significantly...
Fingerprinting Cancer via Multiparameter Extracellular Vesicle Analysis
Project Summary Electronic BioSciences (EBS) proposes, in collaboration with Distinguished Professor Henry White at the University of Utah, to develop a nanopore-based extracellula...
Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)
Glioblastomas rank among the most lethal of all human cancers. Current therapy includes maximal surgical resection, followed by combined radiotherapy and oral chemotherapy (temozol...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Mechanistically Dissecting Glycolysis Regulation by Lactate and Its Therapeutic Potential in Cancer
PROJECT SUMMARY/ABSTRACT Glucose is an essential fuel for cancer cell proliferation in serving both as a substrate for ATP production and as an irreplaceable carbon source for biom...
Colorado's Partnership to Implement Evidence-Based Interventions to Reduce the Cancer Burden
Abstract The University of Colorado Cancer Center (UCCC) and the Colorado Cancer Coalition (CCC) will collaborate to develop regional networks to implement cancer control intervent...
Targeting CD133 for imaging and therapy in prostate cancer
ABSTRACT Aggressive variant prostate cancer (AVPC) arises in men who have failed treatment with second-generation anti-androgen therapy.Not driven by the androgen receptor-signalin...
Advancing the translatability of mouse models for cancer immunotherapy
ABSTRACT: One of greatest challenges in oncology is eradicating cancer once it has metastasized.Cancer immunotherapy (IMT) with checkpoint blockade drugs like ?-PD1 has shown remar...
Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)
Glioblastomas rank among the most lethal of all human cancers.Current therapy includes maximal surgical resection, followed by combined radiotherapy and oral chemotherapy (temozolo...
Correlating mechanical and genetic data at high-throughput and single cell levels to investigate metastasis
Metastasis is the cause of 90% of cancer-related deaths, a statistic that has changed little over the past 50-years.During that time, cancer researchers have recognized that change...