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20,252 grants found
Showing 1,641 – 1,660 of 20,252 grants
CaREER: Cancer Research Education Excellence in Radiotherapy
Project Abstract Radiotherapy (RT) is used in the treatment of over 50% of cancer patients. Despite major technological developments, RT is still critically limited by normal tissu...
Elucidation of a novel transcriptional reprogramming-induced mechanism of endocrine resistance and therapeutic targeting
ABSTRACT Breast cancer is the most common cancer and the second leading cause of cancer mortality in women in the U.S. Approximately 75% of breast cancers are estrogen receptor (...
The oral-gut axis in colorectal cancer
PROJECT SUMMARY/ABSTRACT: Microbes have been implicated in colorectal cancer (CRC) pathogenesis, but definitive knowledge awaits of the identities of contributing microbes and thei...
A compact beam delivery system enabling ultra-fast dose delivery for upright proton therapy
Project Summary/Abstract This project aims to develop a compact fixed beamline solution incorporating Fixed-Field Alternating Gradient (FFA) technology and a novel ultra-fast energ...
Neoadjuvant Tucatinib plus Trastuzumab in HER2-amplified Locally Advanced Rectal Cancer
PROJECT SUMMARY/ABSTRACT Current standard tri-modality therapy (chemotherapy, radiation, and surgery) for locally advanced rectal cancer is associated with high morbidity and only...
Molecular features promoting sensitivity to LSD1i in castration-resistant prostate cancer
Prostate cancer (PCa) remains an incurable disease once progression to the metastatic castration-resistant (mCRPC) state occurs; killing >30,000 U.S. men/yr. Unfortunately, each...
Identifying molecular vulnerabilities of ALT-dependent cancers
PROJECT SUMMARY Telomeres are specialized protein-DNA structures that protect the ends of linear chromosomes and maintain genomic stability. Maintenance of adequate telomere length...
Targeting dsRNA sensing and ADAR1 in melanoma
PROJECT SUMMARY: Over the past decade the development of immune checkpoint blockade (ICB) in melanoma and other tumor types has transformed the treatment options available for many...
Improving risk stratification for lung cancer screening using peripheral blood leukocyte DNA methylation: an investigation in the National Lung Screening Trial (NLST)
Project Summary Lung cancer is the leading cause of cancer death in the US, accounting for approximately 22% of all cancer deaths. Annual screening with low-dose computed tomograph...
A Real-Time Hyperspectral Laparoscopic Stereo Imaging System for Robot-Assisted Surgery
Faster recovery, reduced hospital stays, and a quicker return to normal activities are the most evident advantages of laparoscopic surgery. More than 13 million laparoscopic proced...
Exploiting A Critical Vulnerability To Glutamine Antimetabolite Therapy in Fibrolamellar Hepatocellular Carcinoma (FLC)
Project Abstract Fibrolamellar hepatocellular carcinoma (FLC) is a rare and often lethal form of liver cancer that primarily affects children and young adults without cirrhosis. Th...
Orally active CBP/p300 degraders
Abstract: The histone acetyltransferase CREB-binding protein (CBP) and its paralogue p300 protein are key transcriptional co-activators and attractive therapeutic targets for human...
Mini-gantry for proton therapy
ABSTRACT We hypothesize that a room-temperature, 360°, isocentric proton therapy gantry fits inside a Linac vault, a.k.a the Mini-Gantry. This would enable the conversion of two ne...
Overcoming Therapy Resistance in SCLC
PROJECT SUMMARY/ABSTRACT Small cell lungcancer (SCLC) is a pulmonary neuroendocrine cancer with very poor prognosis and limited effective therapeutic options. Chemotherapy has been...
Analyzing DNA replication and damage vulnerability in IDH mutant glioma
Project Summary Adult diffuse gliomas that harbor mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) are common in younger adults, and universally evade the curren...
Hepatic Tissue Integrity and Clonal Fitness: Key Factors in Controlling β-Catenin Induced Oncogenesis
PROJECT SUMMARY Given the importance of mutations in oncogenes and tumor suppressor genes, it has been widely assumed that the mere accumulation of mutations is the primary process...
A Novel Strategy of Targeting Transmembrane Protein to Improve KRAS-targeted Therapy
Project Summary/Abstract Pancreatic cancer is the most common form of pancreatic cancer and is currently incurable. Unraveling essential cellular reprograming required for PDAC dev...
Melanoma Resistance Evolution Atlas (MREA) for identifying combinatorial targets to prevent and reverse MAPKi resistance
Project Summary The benefit of MAPK inhibitor (MAPKi) therapy for melanoma has been limited to patients with BRAFV600 mutant melanoma. Since the development of MEK inhibitor (MEKi)...
Mechanisms and therapeutic targeting of lethal prostate cancer master regulator transcription factors
SUMMARY Prostate cancer (PCa) is the most frequent malignancy and a leading cause of cancer death in men in the United States. Once PCa progresses to an advanced metastatic therapy...
Combined inhibition of ATR and p110β as Therapy in PTEN-deficient Prostate Cancer
Project Summary/Abstract Given the high mortality of castration-resistant prostate cancer (CRPC) as a result of relapse after androgen deprivation therapy (ADT), novel treatment st...