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20,252 grants found
Showing 16,561 – 16,580 of 20,252 grants
Spinal cord stimulation for the attenuation of chemotherapy-induced peripheral neuropathy and enhanced chemotherapeutic efficacy
Project Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of cancer treatment drugs that often presents as debilitating pain in a stoc...
Germline and Somatic Genomic Studies in CLL Minorities
African Americans are significantly underrepresented in cancer research.Although there have been recent efforts toward more inclusion of African Americans in cancer research, subst...
Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic Cancer
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have minimal effects in cancers lacking intra?tumoral T...
Investigating apoptotic priming as a determinant of sensitivity to leukemia-directed therapies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a clonal expansion of precursor blood- forming cells. Intensive chemotherapy has bee...
Understanding drug delivery through an integrated barcoding approach
Project Summary Despite being hailed as the ?magic bullet? that would selectively target and cure cancer, only a handful of nanoparticles have been successfully translated to the c...
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
PROJECT SUMMARY Pancreatic cancer is a major health issue in the US, with only 7% of patients surviving beyond 5-years and nearly all patients presenting with metastases.Identifyin...
Targeting an unrecognized checkpoint on T cell function in tumors
PROJECT SUMMARY/ABSTRACT A diverse accumulation of infiltrating immune cells is a prominent feature of nearly all cancers1.By directing the effector functions of cancer-killing T c...
Chromosomal Instability as a Marker and Mechanism of Radiation Response
ABSTRACT Human Papilloma Virus (HPV) causes nearly 5% of all cancers worldwide and is implicated in 95% of cervical and 70% of oropharyngeal cancers (OPC).Curative platinum-based c...
Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening
Abstract Esophageal cancer is the 6th leading cause of cancer death worldwide; rates of esophageal adenocarcinoma (EAC) have risen exponentially over the past 4 decades. When EAC i...
Mechanisms associated with organotropic metastasis
ABSTRACT Most cancer patients with solid tumors die of metastatic disease and organotropic spread is an understudied aspect of metastasis, for which new insights are urgently requi...
Cause and therapeutic impact of DNA-protein crosslink repair defect in myeloid leukemias
ABSTRACT Acute myeloid leukemias (AMLs) are a genetically heterogeneous group of clonal hematopoietic disorders characterized by accumulation of immature non-lymphoid marrow progen...
A Genetically Tractable Mouse Model for PRKCI-driven Lung Squamous Cell Carcinoma
Project Abstract Lung cancer is the number one cause of cancer death in the United States.Non-small cell lung cancer (NSCLC), which accounts for the majority (80%) of lung cancer d...
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance
SUMMARY.Kinase inhibitors targeting the catalytic subunit of the DNA-dependent protein kinase (DNAPKcs) are being developed to sensitize tumors to clastogenic (chromosomal-breaking...
Dynamic prediction incorporating time-varying covariates for the onset of breast cancer
PROJECT SUMMARY Accurate assessment of risk is a top priority in oncology due to the population burden of cancer.Breast cancer is the leading cancer diagnosis among women worldwide...
Genetic dissection of oncogenic Kras signaling
ABSTRACT Lung cancer is a prevalent cancer type that leads to more deaths than the next four major cancer types combined. KRAS is one of the most frequent oncogenes in human lung c...
THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA
AML is the most common acute leukemia in adults, and it appears increasingly with age.Despite overall improvement in the treatment of leukemia, AML still carries a devastating prog...
Elucidating the molecular mechanisms of PRMT5i response and resistance in LUAD and PDAC
Project Summary Protein arginine methyltransferase 5 (PRMT5) is part of a methyltransferase complex that symmetrically dimethylates arginine residues in a wide range of proteins re...
The role of an invasive phenotype in promoting resistance to MAPK-directed therapies in thyroid cancer
Thyroid cancer is the most common endocrine malignancy, accounting for over 52,000 new diagnoses each year.Advanced papillary thyroid cancer (PTC) and anaplastic thyroid cancer (AT...
The Effect of Tumor Burden on Peripheral cDC1 Activation and Functionality
PROJECT SUMMARY/ABSTRACT Tumors disrupt the homeostasis of the immune system, altering immune cell composition and phenotype in the tumor microenvironment (TME), lymph nodes, splee...
Acceptance and Commitment Therapy for Fear of Recurrence in Breast Cancer Survivors
PROJECT SUMMARY / ABSTRACT Following treatment for early-stage cancer, most survivors fear the possibility of a recurrence.While mild and intermittent for many, these fears become...