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20,252 grants found
Showing 16,541 – 16,560 of 20,252 grants
Targeting the DNA Damage Response in CDK12-Mutant Prostate Cancer
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer death among men in the United States.While early-stage prostate cancers often respond to hormonal therapy,...
Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
PROJECT SUMMARY The overall goal of the proposed research is to understand the role of Twist1 in cutaneous squamous cell carcinoma (cSCC) and to develop novel approaches for target...
Developing mathematical model driven optimized recurrent glioblastoma therapies
Abstract High-grade gliomas, including GBM, are the most common primary brain tumors in adults. GBM treatment is not curative, and recurrent high-grade glioma (rHGG) remains fatal,...
Metabolic reprogramming to improve EGFRvIII CAR T cell persistence
ABSTRACT Adoptive immunotherapy using chimeric antigen receptor (CAR) T cells has been successful against some liquid tumors, but has failed to cure solid tumors. A key reason for...
Precision targeting of bladder cancer using CRISPR technology
ABSTRACT Chromosome rearrangements are common in cancers and typically occur early in carcinogenesis.They drive tumor development by altering the expression or function of oncogene...
Increasing aerobic and muscle-strengthening physical activity in Latinas via interactive web-based technology
ABSTRACT Cancer is the leading cause of death among Latinos in the U.S.While engaging in a physically active lifestyle is one of the most important modifiable behaviors for reducin...
Development of a clinically relevant mouse model of ER+ breast cancer
The purpose of this proposed R21 project is to develop and validate a novel, clinically relevant mouse model for estrogen receptor-positive (ER+) breast cancer. Most human breast c...
Structural Surfaceomics: A Strategy for Immunotherapy Target Discovery
PROJECT SUMMARY/ABSTRACT Engineered cellular therapies, such as CAR-T cells, hold great promise as ?living drugs?.However, the application of this approach beyond B-cell origin mal...
Cellular Sources of Pathological Stromal Variants
Hepatocellular carcinoma (HCC) accounts for >80% of primary liver cancers and is the fourth most common cause of cancer-related death. Based on populations projections in 2005,...
Determining the significance of the N-MYC-WDR5 interaction in neuroblastoma.
PROJECT SUMMARY/ABSTRACT Neuroblastoma (NB) is the most common extracranial solid tumor found in infants, with almost all cases being diagnosed by the age of five.The most severe c...
Dose-Rate Variations for Patient Treatments in Flash and conventional radiation therapy
Radiation therapy has been an important component in the treatment of cancer for many decades.While the parameters of tumor control have been relatively well understood, normal tis...
Evaluating Etiological Impact of Metatranscriptomic and Immunological Features for Lung Cancer
ABSTRACT There is increasing evidence that the evolution of cancer is strongly dependent on the complex tumor microenvironment (TME) in which it develops.Despite the important role...
Adoptive Cellular Therapy of T Cell Lymphoma
PROJECT SUMMARY Peripheral T cell lymphomas (PTCL) are a highly heterogeneous group of neoplasms that account for 10-30% of all Non-Hodgkin Lymphomas.Of these, angioimmunoblastic T...
Development of non-ATP competitive chemical biology probes to elucidate mechanisms of PLK1 activation and stability.
Polo-like kinase 1 (PLK1) is a central player in regulating entry into and progression through mitosis.Many studies have validated PLK1 as an anti-tumor drug target, and its inhibi...
A Novel Paradigm for the Development of a Peptide Vaccine to Treat KRAS Mutant Cancers
Abstract Ras mutations are highly prevalent in many human tumors but translating this major discovery into effective therapeutics has been difficult. Immunotherapy has emerged as t...
Synergistic DNA repair genes and sensitivity to radiation therapy in prostate cancer
PROJECT SUMMARY/ABSTRACT In the U.S, over 33,000 patients die yearly from prostate cancer (PCa), and an estimated 190,000 new cases are diagnosed. 10-20% of these patients are diag...
MyGI Diet for Colorectal Cancer Prevention
PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Her...
Enhancing the efficacy of androgen signaling inhibitors in prostate cancer
Title: Enhancing the efficacy of androgen signaling inhibitors in prostate cancer Abstract It has been documented that androgen receptor (AR) signaling remains to play a critical r...
Mechanisms of Arginine Deprivation in Small Cell Lung Cancer
Project Summary Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung tumor responsible for over 30,000 deaths each year in the US.SCLC has a two-year survival r...
CONNECT: COmpreheNsive traiNing and Engagement in Cessation Treatment
PROJECT SUMMARY Adult smoking prevalence in the United States (US) is approximately 14% nationwide, yet significant disparities persist, including among adults with annual househol...