Browse All Grants
20,252 grants found
Showing 16,521 – 16,540 of 20,252 grants
Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis
PROJECT SUMMARY/ABSTRACT As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the United States.Although low-...
Urine based circulating tumor DNA analysis
ABSTRACT Urine is an underappreciated source for systemic circulating tumor DNA in patients with non-genitourinary cancers.Based on recent data suggesting that blood-based HPV DNA...
A pro-metastatic secretory pathway activated by p53 loss in lung cancer
Cancer cells are embedded in a protective and nourishing ?niche?, an environment that cancer cells create by secreting proteins into their surroundings.Because cancer cells depend...
Regulation of DNA replication kinetics by BRCA2 after DNA damage
Germline mutations in BRCA2 predispose carriers to breast, ovarian, pancreatic, and other cancers.The gene encodes a very large protein that plays critical roles in genome integrit...
Innate Immune Mechanisms Contributing to Cancer Growth in Obesity
Project Summary/Abstract Colorectal cancer (CRC) is the second leading cause of cancer mortality in the United States, and obesity, which affects 40% of the population, not only in...
Statistical methods for cancer mutational signatures
Project Summary Carcinogens and evolutionary pressures generate unique patterns in the types of somatic mutations observed in the DNA of cancer cells. Mutational signature analysis...
Targeting cellular double-stranded RNA homeostasis in breast cancer
Summary/Abstract The immunologically inactive (cold) tumor is a major challenge for effective immunotherapies in many cancers, including breast cancer.Increasing evidence has demon...
Androgen receptor pathway inhibition through targeting PARP-2 in castration-resistant prostate cancer
ABSTRACT Androgen receptor (AR) is ligand-activated transcription factor and a driver of prostate cancer (PCa).Understanding the molecular mechanisms of AR-mediated transcription i...
Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapy
Project Summary Cancer is a leading cause of death worldwide.Recent advancements in the use of immune checkpoint blockade have transformed oncology, and immunotherapy has extended...
The role of CEACAM1 in oncogenic B-cell receptor signaling and immunotherapy in mantle cell lymphoma
Abstract Mantle cell lymphoma (MCL) accounts for 6-8% of all non-Hodgkin lymphomas (NHLs).While substantial therapeutic advances have been achieved for other NHLs, MCL remains an i...
Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
Project Summary/Abstract: The anaphase-promoting complex/Cyclosome (APC/C) is a well-defined multi-subunit E3 ubiquitin ligase that regulates targeted cell cycle regulators for deg...
3D Ultra-sensitive Ultrasound Microvessel Imaging for Breast Mass Differentiation
PROJECT SUMMARY Breast cancer, the second-leading cause of cancer deaths among women, affects millions of Americans. Early cancer detection and accurate tumor diagnosis are crucial...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...
Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is projected to become the 2nd leading cause of cancer-related deaths world-wide by 2030, largely due a lack of effe...
Novel strategy combined with targeted radiation therapy unleashes potent antitumor immunity in HPV + head and neck cancer
Project Summary/Abstract The overwhelming public health burden of HPV-associated head and neck cancer (HNC) has created great demand for novel, broadly effective therapies with red...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Anti-tumor efficacy of novel cGAS-STING pathway agonists
PROJECT SUMMARY The goal of this proposal is a molecular and immunological examination of novel compounds that activate innate immune signaling mediated by the proteins cyclic GMP-...
Engineered Enteric Nervous System-Peri Neural Invasion platform to improve predictive preclinical screens in early-stage colorectal adenocarcinomas
PROJECT SUMMARY The objective of this proposal is to engineer and utilize enteric nerve plexi as a tool to improve predictive accuracy of preclinical screens in early stage II-III...
Fatty acid synthase in regulation of UDP-GlcNAc synthesis in colorectal cancer
PROJECT SUMMARY Altered metabolism is rapidly emerging as a target for therapeutic intervention in cancer.An increased rate of lipid synthesis in cancer has been recognized as an i...
Therapeutic potential of targeting DNA repair deficiency in TSC
PROJECT SUMMARY/ ABSTRACT Using next-generation sequencing, researchers have identified somatic mutations as essential for tumor etiology and evolution. We now know that many cance...