Browse All Grants
20,252 grants found
Showing 16,501 – 16,520 of 20,252 grants
Infection-Associated Cancer Research Training Program in Mali
PROJECT SUMMARY The Northwestern University (NU) and Mali?s University of Sciences, Techniques, and Technologies of Bamako (USTTB)?s Infection-Associated Cancer (NM-IAC) Research T...
The Role of BCL2 Mediated Calcium Signaling in Leukemia Stem Cell Metabolism
PROJECT SUMMARY The objective of this study is to define the molecular mechanisms that control survival of malignant stem cells in acute myeloid leukemia (AML).Acute myeloid leukem...
UCSF Paul Calabresi K12 Career Development Program in Clinical Oncology
Project Summary/Abstract The goal of the UCSF Paul Calabresi Career Development Award for Clinical Oncology is to foster the development of the next generation of clinical scientis...
Discovering Network-Based Drivers of Single-Cell Transcriptional State in Tumor Immune Microenvironment to Reveal Immuno-Therapeutic Targets and Treatment Synergies
Project Summary/Abstract: Solid tumors consist not only of tumor cells, but also of immune cell types infiltrating the tumor micro- environment.Traditional approaches to cancer the...
Mechanisms of Hedgehog signaling in glioblastoma
Project summary Glioblastomas are deadly tumors and account for approximately half of all malignant primary brain cancers.Glioblastoma stem cells exist in interchangeable cellular...
Regulatory T cells in cancer therapy
Project Summary Extensive studies have been conducted to define the development, conversion, stability, and regulatory mechanisms of CD4+Foxp3+ regulatory T cells (Tregs) in homeos...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death.Within the same...
Dissecting the Role of Proteostasis in Anti-Androgen Resistant Prostate Cancer
PROJECT ABSTRACT In the United States, prostate cancer (PCa) is predicted to be the second leading cause of cancer related death in men in the United States in 2020.After initial d...
Using dietary glutamine supplementation for melanoma prevention and targeted therapy
PROJECT SUMMARY Despite recent advances in cancer metabolism, whether and how nutritional interventions affect tumor development, metastasis and therapeutic response are still poor...
Thymic PD-1 blockade mediates the anti-tumor immune response in pediatric high-grade glioma
Project Summary/Abstract Programmed cell death 1 (PD-1) and its ligands, PD-L1 and PD-L2, are highly expressed in human and murine thymus.Despite this knowledge, the function of th...
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer.Despite recent successes in immune checkpoint therapy of several human cancer ty...
Same-day Breast Pathology Results using Open-Top Light-Sheet Microscopy for Image-guided Core Needle Biopsies
Abstract (300 words maximum) Each year, over 700 women undergo an image-guided core needle biopsy (CNB) to evaluate a suspicious breast finding at the Seattle Cancer Care Alliance,...
Development of an Integrated mHealth App-Based Intervention to Support Smoking Cessation in People Living with HIV
PROJECT SUMMARY / ABSTRACT The advent of highly active antiretroviral therapy (HAART) has greatly reduced mortality in persons living with HIV (PLWH), to the point where now lifest...
Oligomannose antigens as conserved immunological targets of Non-Hodgkin lymphomas
PROJECT SUMMARY Non-Hodgkin lymphoma (NHL) is primarily of B-cell origin but is substantially heterogeneous, which makes developing a tumor-specific immunotherapy for it difficult....
Rational in situ programming of cancer vaccine-responding T-cell clones
Project Summary Currently no method exists that would allow physicians to rapidly and reliably establish T-cell immunity against tumor antigens.Bioinformatics tools can predict ant...
High-Throughput Screen for the Oncoprotein MYC
ABSTRACT MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apop...
Developing novel bispecific antibodies for cancer treatment
PROJECT SUMMARY The overall goal of this project is to improve activities of therapeutic antibodies against cancer metastasis through developing novel bispecific antibodies (BsAbs)...
Androgen Signaling in CaP with loss of MAP3K7 and CHD1
Prostate cancer is characterized by large genomic rearrangements and deletions. We show that the genes CHD1 and MAP3K7 are co-deleted in ERG translocation negative prostate cancer....
Personalized Adoptive T-cell Therapy for AML
Abstract/Project Summary The development of strategies to expand and activate AML specific T cells is of critical importance.We have developed a personalized cancer vaccine in whic...
Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma
PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide and its incidence is rising in both men and women in the United States.Anti...