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20,252 grants found
Showing 16,481 – 16,500 of 20,252 grants
2021 Mammalian DNA Repair Gordon Research Conference and Seminar
Summary of the 2021 Mammalian DNA Repair GRC and GRS This 5-day GRC + 1.5-day GRS conference is focused on the research of genomic instability and its implications in human disease...
VDX-111: A novel targeted therapeutic for triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancers (TNBC) represent a significant challenge to basic scientists studying the molecular underpinnings of the disease and to patients and...
The role of the macroenvironment in pancreatic cancer-induced cachexia
PROJECT SUMMARY: OVERALL The overall goal of this Program Project is to gain a better understanding of the underlying mechanisms that drive cachexia in cancer patients, especially...
Project 1 – IL-6/STAT3/NF-kB in Adipose-Muscle Crosstalk in the Pancreatic Cancer Macroenvironment
PROJECT SUMMARY: PROJECT 1 Cancer cachexia, or progressive weight loss featuring immunodysmetabolism, causes ~1/3 of cancer deaths.Loss of muscle mass reduces performance status, p...
Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia
PROJECT SUMMARY: PROJECT 2 Cachexia is a debilitating syndrome that results in severe, involuntary weight loss due to the depletion of skeletal muscle and adipose tissues. This syn...
Project 3 – Stromal derived IL-6/STAT3 signaling in the development and progression of PDAC
PROJECT SUMMARY: PROJECT 3 PDAC is among the most deadly malignant solid tumors, with approximately 92% of patients succumbing to the disease within five years of diagnosis, and wi...
Core A - Administration
PROEJCT SUMMARY: CORE A The Administrative Core will provide centralized grant administration, data processing and administrative support for the projects.This Core will also serve...
Core B – Human Biospecimen and Advanced Sequencing Core
PROJECT SUMMARY: CORE B The goal of this Program is to advance knowledge of pancreatic ductal adenocarcinoma (PDAC), a recalcitrant cancer with one of the highest rates of cachexia...
Core C – Immunophenotyping Core
SUMMARY: CORE C Cachexia is a wasting syndrome that significantly contributes to the morbidity and mortality of cancer patients, especially those diagnosed with pancreatic ductal a...
Core D – Biostatistics Core
SUMMARY: CORE D The Biostatistics Core provides centralized and state-of-the-art support to meet the data management and analytic needs of the Program Project Grant.Core personnel...
Decoding Individual Exosomes in Cancer
PROJECT SUMMARY There is increasing recognition that extracellular vesicles (EVs)¾micrometer- or nanometer-sized lipid particles containing protein and nucleic acid cargoes (inform...
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
Project Summary Poor diet and excess weight during adolescence predicts excess weight and diet-related cancers during adulthood, yet there is little research on the risk factors th...
Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles
PROJECT SUMMARY Clinical implementation of Precision Medicine faces major challenges in precision disease stratification and staging, determining optimal treatment, monitoring ther...
Novel Treatment Strategies for Cancer
PROJECT SUMMARY: Novel treatment strategies for cancer The urgent need to develop effective treatments for non-clear cell renal cell carcinomas (NCCRCC) is underscored by consisten...
Optimizing NK Cell-Engaging Bispecific Antibody Therapy Targeting CD33
ABSTRACT CD33-targeted therapies have long been pursued in acute myeloid leukemia (AML).Longer survival of some patients treated with the antibody-drug conjugate gemtuzumab ozogami...
Metabolic Control and Anticancer Mechanism
ABSTRACT As a central controller of cancer growth and metabolism, mTORC1 pathway is commonly mutated and activated in human cancer, leading to uncontrolled growth. Cancer cells are...
Statistical methods for cancer progression delineation and subtype identification
Project Summary Carcinogenesis is a complex process involving somatic mutations in a number of key biological pathways and processes.Full study of the temporal order of somatic mut...
Rational design of drug combinations to target chemotherapy resistance in high-grade serous ovarian cancer via metabolomic profiling of patient-derived organoids
Project Summary/Abstract This resistant disease rates women, metabolomics resistance, of algorithm To regulatory of organoids. identified therapies project aims to develop a novel,...
New Statistical Methods for Cox Regression with Measurement Errors in Cancer and Nutritional Epidemiology
Project Summary / Abstract One of the greatest challenges in cancer and nutritional epidemiology is the uncertainty in covariate measurements, which is a major source of bias in re...
Dynamic µOCT for cellular tissue phenotyping
Phenotyping cells and tissue is a critical function that spans basic science to clinical diagnosis.Yet, established methods for phenotyping cells in tissue are static, are evaluate...