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20,252 grants found
Showing 16,461 – 16,480 of 20,252 grants
Cause and therapeutic impact of DNA-protein crosslink repair defect in myeloid leukemias
ABSTRACT Acute myeloid leukemias (AMLs) are a genetically heterogeneous group of clonal hematopoietic disorders characterized by accumulation of immature non-lymphoid marrow progen...
Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening
Abstract Esophageal cancer is the 6th leading cause of cancer death worldwide; rates of esophageal adenocarcinoma (EAC) haverisen exponentially over the past 4 decades. When EAC is...
Investigating apoptotic priming as a determinant of sensitivity to leukemia-directed therapies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a clonal expansion of precursor blood- forming cells. Intensive chemotherapy has bee...
A Novel Paradigm for the Development of a Peptide Vaccine to Treat KRAS Mutant Cancers
Abstract Ras mutations are highly prevalent in many human tumors but translating this major discovery into effective therapeutics has been difficult. Immunotherapy has emerged as t...
Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas
Project Summary/Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous and poorly understood pathological group of non-Hodgkin lymphomas associated with poor progno...
Personalized Adoptive T-cell Therapy for AML
Abstract/Project Summary The development of strategies to expand and activate AML specific T cells is of critical importance. We have developed a personalized cancer vaccine in whi...
Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic Cancer
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have minimal effects in cancers lacking intra–tumoral T...
Ultra-sensitive Singlet Oxygen Dosimeter for Skin Cancer Treatment and Prevention
Project Summary/Abstract Skin cancer is the most common form of cancer. Each year in the U.S. alone over 5.4 million cases of nonmelanoma skin cancer are treated. The annual cost o...
A pro-metastatic secretory pathway activated by p53 loss in lung cancer
Cancer cells are embedded in a protective and nourishing “niche”, an environment that cancer cells create by secreting proteins into their surroundings. Because cancer cells depend...
Cellular Sources of Pathological Stromal Variants
Hepatocellular carcinoma (HCC) accounts for >80% of primary liver cancers and is the fourth most common cause of cancer-related death. Based on populations projections in 2005,...
Statistical methods for cancer mutational signatures
Project Summary Carcinogens and evolutionary pressures generate unique patterns in the types of somatic mutations observed in the DNA of cancer cells. Mutational signature analysis...
Engineered Enteric Nervous System-Peri Neural Invasion platform to improve predictive preclinical screens in early-stage colorectal adenocarcinomas
PROJECT SUMMARY The objective of this proposal is to engineer and utilize enteric nerve plexi as a tool to improve predictive accuracy of preclinical screens in early stage II-III...
Precision targeting of bladder cancer using CRISPR technology
ABSTRACT Chromosome rearrangements are common in cancers and typically occur early in carcinogenesis. They drive tumor development by altering the expression or function of oncogen...
Androgen Signaling in CaP with loss of MAP3K7 and CHD1
Prostate cancer is characterized by large genomic rearrangements and deletions. We show that the genes CHD1 and MAP3K7 are co-deleted in ERG translocation negative prostate cancer....
MyGI Diet for Colorectal Cancer Prevention
PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Her...
Realizing the radiobiological impact of protons and high-LET particles in head and neck cancer and glioblastoma models
Project Summary Radiotherapy is still one of the most effective cancer treatments used to treatment ~50 % of all human cancers, and particularly solid tumours of the head and neck...
A transcription-independent role of HSF1 in tumorigenesis via suppression of AMPK
Project Summary There is an urgent need to develop new therapeutic options for carcinogenesis.The goal of this proposal is to help fulfill this need by shedding new light on the mo...
Improving the Timeliness and Quality of Care for Rural Lung and Head-and-Neck Cancer Patients
ABSTRACT: Improving the timeliness and quality of care for lung cancer (LC) and head and neck cancer (HNC) patients is of utmost importance because delays in treatment initiation a...
Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
Project Summary/Abstract: The introduction of multi-gene panel testing for hereditary breast and ovarian cancer (HBOC) syndrome has rapidly changed the clinical approach to genetic...
Realizing the radiobiological impact of protons and high-LET particles in head and neck cancer and glioblastoma models
Project Summary Radiotherapy is still one of the most effective cancer treatments used to treatment ~50 % of all human cancers, and particularly solid tumours of the head and neck...