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20,252 grants found
Showing 16,441 – 16,460 of 20,252 grants
Targeting the DNA Damage Response in CDK12-Mutant Prostate Cancer
PROJECT SUMMARY Prostate cancer is the second most common cause of cancer death among men in the United States. While early-stage prostate cancers often respond to hormonal therapy...
RNase H2 is a novel therapeutic target in triple negative breast cancer
Project Summary Due to their hyperproliferative nature and intrinsic genomic instability, triple-negative breast cancer (TNBC) cells exhibit high levels of replication stress, whic...
Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma
PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide and its incidence is rising in both men and women in the United States. Ant...
Spinal cord stimulation for the attenuation of chemotherapy-induced peripheral neuropathy and enhanced chemotherapeutic efficacy
Project Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of cancer treatment drugs that often presents as debilitating pain in a stoc...
NCI Pediatric In Vivo Testing Program: Neuroblastoma
Project Summary Children with disseminated neuroblastoma have a very high risk of treatment failure and death despite receiving intensified chemotherapy, radiation therapy and immu...
Developing mathematical model driven optimized recurrent glioblastoma therapies
Abstract High-grade gliomas, including GBM, are the most common primary brain tumors in adults. GBM treatment is not curative, and recurrent high-grade glioma (rHGG) remains fatal,...
In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
PROJECT SUMMARY Despite the advances made in our understanding of the etiology of pediatric soft tissue sarcomas (STS), the overall survival of those diseases has not significantly...
Development of non-ATP competitive chemical biology probes to elucidate mechanisms of PLK1 activation and stability.
Polo-like kinase 1 (PLK1) is a central player in regulating entry into and progression through mitosis. Many studies have validated PLK1 as an anti-tumor drug target, and its inhib...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Plk1 as a prognostic biomarker for prostate cancer
Title: Plk1 as a prognostic biomarker for prostate cancer Abstract Because androgen receptor (AR) signaling is essential for development of prostate cancer (PCa), including castrat...
Metabolic reprogramming to improve EGFRvIII CAR T cell persistence
ABSTRACT Adoptive immunotherapy using chimeric antigen receptor (CAR) T cells has been successful against some liquid tumors, but has failed to cure solid tumors. A key reason for...
Epigenetically Engineered Mouse Model for Lung Cancer Therapy
PROJECT SUMMARY (Abstract) The importance of aberrant DNA methylation in cancer is clear. The fundamental role of DNA methylation in cancer initiation and progression, however, rem...
Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
Project Summary/Abstract: The anaphase-promoting complex/Cyclosome (APC/C) is a well-defined multi-subunit E3 ubiquitin ligase that regulates targeted cell cycle regulators for deg...
Germline Structural Variant Identification and Functional Determination in Childhood Cancer
Abstract A few germline pathogenic structural variants (SV) have been identified in cancer predisposition syndromes, e.g., MSH2 inversion in Lynch syndrome. The advent of short-rea...
Development of AMPK Inhibitors for the treatment of leukemia
PROJECT SUMMARY Despite advances in the treatment of acute myeloid leukemia (AML), only 20–30% of patients achieve long-term disease-free survival (DFS) and treatment options for r...
Understanding drug delivery through an integrated barcoding approach
Project Summary Despite being hailed as the “magic bullet” that would selectively target and cure cancer, only a handful of nanoparticles have been successfully translated to the c...
Chromosomal Instability as a Marker and Mechanism of Radiation Response
ABSTRACT Human Papilloma Virus (HPV) causes nearly 5% of all cancers worldwide and is implicated in 95% of cervical and 70% of oropharyngeal cancers (OPC). Curative platinum-based...
Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children, with T-cell ALL accounting for 15% of cases. T-ALL in children is associated with aggressive clin...
The role of Epstein Barr Virus and Human Papilloma Virus Co-infection in Conjunctival Squamous Cell Carcinoma.
PROJECT SUMMARY Conjunctival Squamous Cell Carcinoma (SCC) is a malignant disease of the eyes, classified under ocular surface squamous neoplasia (OSSN) (Gichuhi et al. 2015). Inci...
Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities
PROJECT SUMMARY/ABSTRACT Cancer is a common diagnosis in the emergency department (ED) and by the time patients reach the ED, their cancer has often progressed to later stages. EDs...