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20,252 grants found
Showing 16,421 – 16,440 of 20,252 grants
Writing to Heal: A Culturally Based Brief Expressive Writing Intervention for Chinese Immigrant Breast Cancer Survivors
Project Summary/Abstract The unavailability of culturally competent mental health care for Chinese immigrant breast cancer survivors and their unmet psychological needs characteriz...
Discovering Network-Based Drivers of Single-Cell Transcriptional State in Tumor Immune Microenvironment to Reveal Immuno-Therapeutic Targets and Treatment Synergies
Project Summary/Abstract: Solid tumors consist not only of tumor cells, but also of immune cell types infiltrating the tumor micro- environment. Traditional approaches to cancer th...
New Statistical Methods for Cox Regression with Measurement Errors in Cancer and Nutritional Epidemiology
Project Summary / Abstract One of the greatest challenges in cancer and nutritional epidemiology is the uncertainty in covariate measurements, which is a major source of bias in re...
Do Tumor-Immune Interactions Prime Systemic Tolerance of Triple-Negative Breast Cancer Brain Metastases?
PROJECT ABSTRACT/SUMMARYIt is widely estimated that 90% of cancer-related deaths are caused by metastasis. This statistic underscores our inability to manage cancer once it dissemi...
The Role of BCL2 Mediated Calcium Signaling in Leukemia Stem Cell Metabolism
PROJECT SUMMARY The objective of this study is to define the molecular mechanisms that control survival of malignant stem cells in acute myeloid leukemia (AML). Acute myeloid leuke...
Real time colon histopathology by infrared spectroscopic imaging
Abstract Colorectal cancer (CRC) is one of the leading causes of death in the US. Active screening and early intervention in risky cancers can lead to good outcomes; however, a bot...
Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapy
Project Summary Cancer is a leading cause of death worldwide. Recent advancements in the use of immune checkpoint blockade have transformed oncology, and immunotherapy has extended...
Novel strategy combined with targeted radiation therapy unleashes potentantitumor immunity in HPV + head and neck cancer
Project Summary/Abstract The overwhelming public health burden of HPV-associated head and neck cancer (HNC) has created great demand for novel, broadly effective therapies with red...
Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients
Project Summary/Abstract The goal of this research project is to investigate new 3D advanced hyperpolarized (HP) 13C-pyruvate MRI techniques to quantitatively monitor metabolic cha...
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
SUMMARY Liver cancer is the fourth leading cause of cancer related mortality worldwide. Currently, in addition to emerging immune checkpoint inhibitors, a small number of structura...
Investigating the structure and function of the human centromere and kinetochore
Project Summary Accurate segregation of chromosomes during cell division is one of the most fundamental requirements in biology. Without proper chromosomal segregation, genetic inf...
Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
Project Summary/Abstract: The introduction of multi-gene panel testing for hereditary breast and ovarian cancer (HBOC) syndrome has rapidly changed the clinical approach to genetic...
Anti-tumor efficacy of novel cGAS-STING pathway agonists
PROJECT SUMMARY The goal of this proposal is a molecular and immunological examination of novel compounds that activate innate immune signaling mediated by the proteins cyclic GMP-...
Targeting an unrecognized checkpoint on T cell function in tumors
PROJECT SUMMARY/ABSTRACT A diverse accumulation of infiltrating immune cells is a prominent feature of nearly all cancers1. By directing the effector functions of cancer-killing T...
PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy
SUMMARY. The problem: Hormone therapy remains the standard treatment for prostate cancer (PC). While most patients initially respond to therapy, they will ultimately progress to le...
High-Throughput Screen for the Oncoprotein MYC
ABSTRACT MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apop...
A transcription-independent role of HSF1 in tumorigenesis via suppression of AMPK
Project Summary There is an urgent need to develop new therapeutic options for carcinogenesis. The goal of this proposal is to help fulfill this need by shedding new light on the m...
Evaluating Etiological Impact of Metatranscriptomic and Immunological Features for Lung Cancer
ABSTRACT There is increasing evidence that the evolution of cancer is strongly dependent on the complex tumor microenvironment (TME) in which it develops. Despite the important rol...
Fatty acid synthase in regulation of UDP-GlcNAc synthesis in colorectal cancer
PROJECT SUMMARY Altered metabolism is rapidly emerging as a target for therapeutic intervention in cancer. An increased rate of lipid synthesis in cancer has been recognized as an...
Regulation of DNA replication kinetics by BRCA2 after DNA damage
Germline mutations in BRCA2 predispose carriers to breast, ovarian, pancreatic, and other cancers. The gene encodes a very large protein that plays critical roles in genome integri...