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20,252 grants found
Showing 16,401 – 16,420 of 20,252 grants
Diversity Supplement to Targeted Therapy in Ex Vivo Medulloblastoma/PNET
PROJECT SUMMARY/ABSTRACT I lead the Children?s Oncology Group Phase III clinical trial, ACNS0332, which evaluates treatment options for children with high-risk medulloblastoma (the...
A Mannose 6-Phosphate Decorated Transformable Nanoplatform for Targeted Uptake in HER2+ Tumors
Abstract Human epidermal growth factor receptor 2 (HER2) is overexpressed in over 20% breast cancers, and to a lesser degree in gastric cancers, colorectal cancer, ovarian cancers...
Racial Differences in Prostate Cancer Molecular Subtyping
ABSTRACT Black men have one of the highest risks of aggressive prostate cancer (PC) in the world. Even in an equal access setting, we found disparities persist, arguing for a biolo...
A Phagocytosis Modulating Nanomedicine for Targeted Breast Cancer Immunotherapy
Project Summary Despite significant advances in the treatment of breast cancer, the metastatic form of the disease remains highly lethal, with a 5-year overall survival rate of onl...
The Center for Therapeutic Targeting of EWS-oncoproteins
PROJECT SUMMARY: Overall This section is unchanged from the U54 CA231637 parent award.The primary scientific focus of this Center is to understand the molecular underpinnings of EW...
Defining mechanisms of thalidomide analog resistance
PROJECT SUMMARY Thalidomide and its analogs, lenalidomide and pomalidomide, have revolutionized the treatment of patients with multiple myeloma (MM) and other hematologic malignanc...
ANNUAL LICENSE FOR ACCESS TO NDSR SOFTWARE FROM UNIVERSITY OF MINNESOTA NUTRITION COORDINATING CENTER IN SUPPORT OF THE NCI DIET HISTORY QUESTIONNAIRE
The contractor currently maintains a research level food and nutrient database used in research.This task provides NCI with access to this database allowing NCI to provide an exten...
Core A - Administrative and Biostatistics Core
PROJECT SUMMARY ? CORE A The Administrative and Biostatistics Core (referred to as Core A).Core A has two interrelated components: Administrative and Biostatistics, which serve to...
SURVEILLANCE EPIDEMIOLOGY AND END RESULTS PROGRAM (SEER)- INDEPENDENT DISCLOSURE RISK EVALUATION OF THE SEER RESEARCH DATABASES
This Call Order provides support for Quality Control and Quality Improvement (QC/QI) activities in the Surveillance Research Program related to SEER database disclosure analysis of...
The role of Interleukin 17RB signaling in colorectal cancer progression
Despite important advances in detection, surgery and chemotherapy, colorectal cancer (CRC) is the second cause of cancer death in the U.S. Most of these deaths are due to cancer pr...
Dissecting the Role of Proteostasis in Anti-Androgen Resistant Prostate Cancer
PROJECT ABSTRACT In the United States, prostate cancer (PCa) is predicted to be the second leading cause of cancer related death in men in the United States in 2020. After initial...
The RNA structural code underlying pathological regulation of RNA splicing in metastasis
PROJECT SUMMARY Widespread aberrant splicing is now considered a hallmark of cancer, and many of the resulting transcript isoforms have been functionally implicated in tumorigenesi...
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
Late stage ovarian cancer is marked by poor patient survival and significant metastatic spread throughout the peritoneal cavity.During transcoelomic spread cells must adapt to surv...
UCSF Paul Calabresi K12 Career Development Program in Clinical Oncology
Project Summary/Abstract The goal of the UCSF Paul Calabresi Career Development Award for Clinical Oncology is to foster the development of the next generation of clinical scientis...
The role of differential bone marrow immune landscape in permissive tumor growth in the spine
PROJECT SUMMARY/ABSTRACT Roughly 400,000 people in the U.S. have bone metastases, the vast majority occurring in the spine. Metastases to the spine results in fractures, pain, para...
Metabolite sensing through the HAT1 acetyltransferase as an anti-cancer target
PROJECT SUMMARY/ABSTRACT This is an application for a K08 for Dr. Joshua Gruber, an Instructor of Medicine at Stanford University. Dr.Gruber wishes to establish himself as a clinic...
Using dietary glutamine supplementation for melanoma prevention and targeted therapy
PROJECT SUMMARY Despite recent advances in cancer metabolism, whether and how nutritional interventions affect tumor development, metastasis and therapeutic response are still poor...
Mechanisms of Hedgehog signaling in glioblastoma
Project summary Glioblastomas are deadly tumors and account for approximately half of all malignant primary brain cancers. Glioblastoma stem cells exist in interchangeable cellular...
Metabolic Control and Anticancer Mechanism
ABSTRACT As a central controller of cancer growth and metabolism, mTORC1 pathway is commonly mutated and activated in human cancer, leading to uncontrolled growth. Cancer cells are...
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
Late stage ovarian cancer is marked by poor patient survival and significant metastatic spread throughout the peritoneal cavity. During transcoelomic spread cells must adapt to sur...