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20,252 grants found
Showing 16,381 – 16,400 of 20,252 grants
TASK ORDER 75N91021F00001 FOR SUPPORT SERVICES FOR DEVELOPING AND PROMOTING METHODS AND STANDARDS FOR CANCER REGISTRY OPERATIONS AND SURVEILLANCE DATA
The objective of this contract is to provide support to the North American Association of Central Cancer Registries (NAACCR) in order to make the National Cancer Institute?s (NCI)...
Dissecting the Execution Phase of BAK-Mediated Apoptosis in Cancer
PROJECT SUMMARY BCL-2 family proteins are critical regulators of apoptosis and deregulation of their protein interactions contributes to the development and chemoresistance of canc...
Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.
PROJECT SUMMARY/ABSTRACT Low-grade glioma (LGG) is a disease that, despite the modern standard of care, frequently recurs or progresses to high- grade glioma, such as glioblastoma...
Understanding the role of TWIST1 in colorectal cancer progression and metastasis
Project Summary: Although almost all colorectal cancer (CRC) mortality is due to metastasis, there are currently no drugs to prevent or halt metastasis. A better understanding of t...
Rational design of drug combinations to target chemotherapy resistance in high-grade serous ovarian cancer via metabolomic profiling of patient-derived organoids
Project Summary/Abstract This resistant disease rates women, metabolomics resistance, of algorithm To regulatory of organoids. identified therapies project aims to develop a novel,...
Optimizing NK Cell-Engaging Bispecific Antibody Therapy Targeting CD33
ABSTRACT CD33-targeted therapies have long been pursued in acute myeloid leukemia (AML). Longer survival of some patients treated with the antibody-drug conjugate gemtuzumab ozogam...
Dose-Rate Variations for Patient Treatments in Flash and conventional radiation therapy
Radiation therapy has been an important component in the treatment of cancer for many decades. While the parameters of tumor control have been relatively well understood, normal ti...
The regulation of mutant p53 protein accumulation in cancer: molecular basis and therapeutic potential
Abstract Tumor suppressor p53 is the most frequently mutated gene in human cancer, including colorectal cancer (CRC). Many tumor-associated mutant p53 (mutp53) proteins not only lo...
Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors
PROJECT SUMMARY Despite the known roles of chromatin remodeling complexes in driving more than 20% of human cancer, the role of chromatin remodeling complexes in conferring therape...
Development of an Integrated mHealth App-Based Intervention to Support Smoking Cessation in People Living with HIV
PROJECT SUMMARY / ABSTRACT The advent of highly active antiretroviral therapy (HAART) has greatly reduced mortality in persons living with HIV (PLWH), to the point where now lifest...
Improving pediatric brain tumor treatments using FLASH radiotherapy
PROJECT SUMMARY Our R01 application entitled, “Improving pediatric brain tumor treatments using FLASH radiotherapy” is focused on translating a novel irradiation modality into clin...
Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors
PROJECT SUMMARY Despite the known roles of chromatin remodeling complexes in driving more than 20% of human cancer, the role of chromatin remodeling complexes in conferring therape...
University of Colorado Cancer Center Support Grant
Abstract The UCCC is the only NCI-designated Cancer Center in Colorado and has as its catchment area the entire State of Colorado.There are conceptually two ?Colorados?: the Front...
Abramson Cancer Center Support Grant
PROJECT SUMMARY ?Abramson Cancer Center The Abramson Cancer Center (ACC) at the University of Pennsylvania is one of the oldest NCI-Designated Comprehensive Cancer Centers.The ACC...
Implementation and Evaluation of an Expanded Bilingual Electronic Symptom Management Program across a Multi-site, Fully-integrated Comprehensive Cancer Center
Project Summary Physical and functional symptom burden is high among cancer survivors and is an ideal target for chronic care management.Cancer-related physical and functional side...
SCH: ChangeGradients: Promoting Health Behavior Change with Clinically Integrated Sample-Efficient Policy Gradient Methods
Because the majority of adolescent health problems are amenable to behavioral intervention and most adolescents visit a healthcare provider once a year, hea lth behavior change int...
Harnessing the Power of p53 with Panaxynol from American Ginseng to Suppress Colitis and Prevent Colon Cancer - admin supp
PROJECT SUMMARY Inflammatory Bowel Disease (IBD) is a chronic condition with a high risk for development of colon cancer. This illness has a high financial burden due to its relaps...
Polarizing Macrophages to Tumor Suppressors by Blocking Multiple CCR2 Chemokine Receptor Epitopes
Project Summary Despite the important role of the tumor stroma in cancer progression, the vast majority of anticancer therapies target cancer cells and not the tumor microenvironme...
An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin
Project Summary Chronic inflammatory conditions such as aging and obesity harmonize with cancer cell mutations to trigger and promote tumor development and progression. Hence, just...
Therapeutic Targeting of Immune Evasion from the MICA - NKG2D Pathway
Project Summary MICA and MICB (MICA/B) are stress proteins that are frequently expressed by diverse types of human cancer as a consequence of genomic damage, but are rarely express...