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20,252 grants found
Showing 1,621 – 1,640 of 20,252 grants
National Succinate Dehydrogenase-deficient GIST Translational Research and Clinical Trial Consortium
PROJECT SUMMARY/ABSTRACT Gastrointestinal stromal tumor (GIST) is often effectively treated with FDA-approved first-line therapies such as imatinib and avapritinib. However, this s...
MS4A7 in tumor resistance to immunotherapy
Project Summary/Abstract: Macrophages are one of the major cellular elements in the tumor microenvironment (TME). Tumor associated macrophages (TAMs) markedly outnumber dendritic c...
Targeting ß-TrCP regulators to improve CRC response to chemotherapy
PROJECT SUMMARY Improved treatment of colorectal cancer (CRC) requires better understanding of key regulators of survival and proliferation of intestinal epithelial cells and their...
The Role of Platelets in Cancer Cachexia
SUMMARY Cancer cachexia is a complex metabolic syndrome characterized by muscle wasting, weight loss, and decreased quality of life. Patients with cancer cachexia experience impair...
Elucidating molecular mechanisms of cabozantinib resistance in liver cancer
ABSTRACT Despite advancements in targeted molecular therapies, hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide, with an average 5-year survival r...
Personalizing genetic test results management and outcomes after diagnosis of cancer: the Georgia-California SEER Genelink Study
Abstract: The rapid diffusion of genetic testing across adult cancer diagnoses is a unique opportunity to personalize cancer treatment and prevention at the population level. Germl...
Molecular Markers for Tumors Associated with Extrachromosomal HPV
3URMHFW 6XPPDU\ In the classical paradigm for cervical cancer, keratinocytes are infected with high-risk HPV (HR-HPV) genomes which become integrated (“iHPV”) into human chromosome...
Mechanisms of paclitaxel sensitivity and resistance
SUMMARY The microtubule poison paclitaxel (PTX) is standard-of-care for breast cancer treatment for all breast cancer subtypes in both early stage and metastatic disease. However,...
The combined role of ARID1A loss and estrogen signaling in endometrial cancer
PROJECT SUMMARY Endometrial cancer is the most common gynecological cancer in the United States and causes more than 12,500 deaths per year with rising incidence and mortality as w...
A novel dual-carrier ultrasmall nanomedicine for the treatment of stroma-rich pancreatic cancer
EXECUTIVE SUMMARY Cancers rich in dense stromal tissue are more difficult to treat and carry a worse prognosis than cancers without the stroma-rich phenotype. The fibrous stroma su...
Clock Disruption Accelerates Colorectal Cancer and Promotes Immunosuppression
ABSTRACT Colorectal cancer (CRC) is the third most diagnosed cancer in the United States. With increasing public knowledge of cancer risk factors and screening, the incidence of CR...
Collagen fibers and fragments regulate pancreatic cancer metabolism and growth.
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, resulting in occupancy of most of the tumor mass by a dense stroma consisting of...
Dissecting high-risk cell states in neuroblastoma
PROJECT SUMMARY/ABSTRACT: Relapsed disease is a key challenge in cancer biology and medicine. Cancer cells are dynamic and exist in flexibly interconverting and epigenetically-spec...
Non-receptor protein tyrosine phosphatases in macrophage-mediated cancer cell phagocytosis.
Project Summary/Abstract Recent breakthroughs in tumor immunology led to the development of cancer immunotherapies which have been successfully applied to a range of human cancers....
Role of the tRNA methyltransferase AlkBH8 in Colorectal Cancer
Project Summary: Reactive Oxygen Species (ROS) are produced as byproducts of oxidative phosphorylation and are found to be elevated in most cancers. In order to prevent ROS mediate...
Deciphering the role of mitochondrial metabolism in liver cancer
Project Summary: Liver cancer is the third leading cause of cancer-related death and is associated with diverse range of oncogenic alterations. These driver mutations impact clinic...
Functionally dissecting MECOM gene regulation in high-risk leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a devastating disease that continues to have a poor prognosis with less than one-third of patients achieving a cure from th...
Paracrine signaling from keratinocytes establishes a pro-melanoma environment
Project Summary Keratinocytes and melanocytes together form the epidermal melanin unit, which is essential for the protective tanning response after ultraviolet radiation (UV) expo...
High-Precision Proton Therapy for Liver Cancer: Developing an End-to-end Strategy with Real-time Liver Tumor Localization and On-the-fly Plan Delivery Adaptation
PROJECT SUMMARY The recent advancement of stereotactic body radiotherapy (SBRT) enables highly focused dose delivery to tumors while sparing surrounding normal tissues. Emerging cl...
Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation
PROJECT SUMMARY/ABSTRACT Targeted cancer therapeutics have traditionally focused on inhibiting activated oncogenic signaling pathways. While such pathway inhibitors have resulted i...