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20,252 grants found
Showing 16,361 – 16,380 of 20,252 grants
Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.
PROJECT SUMMARY/ABSTRACT Low-grade glioma (LGG) is a disease that, despite the modern standard of care, frequently recurs or progresses to high- grade glioma, such as glioblastoma...
The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment
Abstract Glioblastoma (GB) is the most common primary tumor of the central nervous system (CNS) in adults. Despite aggressive surgery, radiation, and chemotherapy, median survival...
Function of Musashi-2 Methylation in Normal and Malignant Hematopoiesis
Project Abstract Acute myeloid leukemia (AML) is an aggressive, heterogeneous disease and is characterized by the expansion of immature myeloid progenitors and the inhibition of my...
PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy
SUMMARY. The problem: Hormone therapy remains the standard treatment for prostate cancer (PC).While most patients initially respond to therapy, they will ultimately progress to let...
The regulation of mutant p53 protein accumulation in cancer: molecular basis and therapeutic potential
Abstract Tumor suppressor p53 is the most frequently mutated gene in human cancer, including colorectal cancer (CRC).Many tumor-associated mutant p53 (mutp53) proteins not only los...
RNA Methylation in Cancer Plasticity and Drug Resistance
PROJECT SUMMARY/ ABSTRACT Cancer drug resistance occurs not only by selection of genetically resistant clones, but also through phenotypic plasticity via rapid induction of transcr...
Adapting and implementing evidence-based breast cancer follow-up in primary care
PROJECT SUMMARY/ABSTRACT Breast cancer survivors are a growing population and their symptom burden is significant.Despite growing evidence on specific symptoms and risk management...
Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children, with T-cell ALL accounting for 15% of cases.T-ALL in children is associated with aggressive clini...
State-of-the-Art Synthesis of Interventions to Promote Quit Intentions and Smoking Cessation
Project Summary Most people who smoke have no intention of quitting in the next 6 months or beyond, which begs critical questions of the field of cancer prevention and control: How...
Vascularized tumor explants for drug testing
Project Abstract Our understanding of cancer progression or response to therapies would benefit from easily accessible, patient- specific assays that recapitulate the biology and a...
Regulation and Function of Very Long Chain Fatty Acid Biosynthesis in Multiple Myeloma
Multiple Myeloma (MM) is a plasma cell disorder that accounts for ~10% of all hematologic malignancies.Due to high production of IgG in endoplasmic reticulum (ER), MM cells continu...
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms
PROJECT SUMMARY/ABSTRACT Ten Eleven Translocation (TET1, TET2 and TET3) are ?-ketoglutarate (?KG) and Fe2+ dependent DNA- dioxygenases that is a key regulator of epigenetic landsca...
Persistent STAT5 signaling in polyfunctional CD4 T cells and its application in adoptive T cell therapy
Project summary/abstract Recent advances in adoptive T-cell therapy (ACT), especially CD19-targeting chimeric antigen receptor (CAR) T-cell therapy (CD19CART), have highlighted the...
Targeting CDK6 expression/activity in Ph+ and Ph1-like acute lymphoblastic leukemia (ALL)
Abstract Philadelphia-positive acute lymhoblastic leukemia (Ph+ ALL) and Ph1-like B-ALL account for most cases of ?high-risk? adult B-ALL.Current therapies with tyrosine kinase inh...
Real time colon histopathology by infrared spectroscopic imaging
Abstract Colorectal cancer (CRC) is one of the leading causes of death in the US.Active screening and early intervention in risky cancers can lead to good outcomes; however, a bott...
Germline Structural Variant Identification and Functional Determination in Childhood Cancer
Abstract A few germline pathogenic structural variants (SV) have been identified in cancer predisposition syndromes, e.g., MSH2 inversion in Lynch syndrome. The advent of short-rea...
Platelet PI3Kbeta regulation of metastasis
Abstract Metastasis is the primary cause of morbidity and mortality among patients with solid tumors.Platelets interact with tumor cells upon their entry into the vasculature and p...
Biochemical and Mechanistic Insights into the Roles of Rad51 Paralogs in Homologous Recombination Repair
PROJECT SUMMARY/ABSTRACT Understanding the molecular pathways disrupted in breast and ovarian cancer is vital to combating these devastating diseases.Hereditary susceptibility to c...
Regional selectivity of oncohistone H3K27M on glial development and glioma pathogenesis
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an incurable high-grade glioma arising in the brainstem primarily in younger children. DIPG 2-year survival rate is
A Novel PET Imaging based Companion Diagnostic
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-20-012.High attrition rates?particularly at the late stage o...