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20,252 grants found
Showing 16,341 – 16,360 of 20,252 grants
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any g...
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
PROJECT SUMMARY/ABSTRACT: The goal of this project is to validate a clinically feasible, one-shot contrast-enhanced, multiparametric MRI approach for mapping the morphologic, hemod...
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any g...
Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer
PROJECT SUMMARY/ABSTRACT Advance care planning and palliative care represent evidence-based, high-quality care for patients with advanced cancer. Early identification of patients a...
Cancer Epigenetics Training (CET) Program
PROJECT SUMMARY This proposal seeks to develop a dedicated Cancer Epigenetics Training (CET) program at Van Andel Research Institute (VARI) to train two new postdoctoral fellows pe...
Metabolite driven mechanisms by which gut microbes impact checkpoint inhibitor success in non-small cell lung cancer patients
ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but clinical responses remain limited due to primary and/or acquired ICI resistance. Preliminary s...
Strategies to Disrupt Oncogenic Transcription in RCC Tumors
• PROJECT SUMMARY • Renal cell carcinoma (RCC) is the 8th most common form of adult cancer in the US. Despite recent improvement in treatment options, the majority of patients with...
Role of PRC1 in RUNX1-ETO-mediated transcriptional control
The goal of this application is to understand how the t(8;21), the most frequent chromosomal translocation associated with acute myeloid leukemia (AML), sets the stage for secondar...
Patient-Generated Health Data to Predict Childhood Cancer Survivorship Outcomes
PROJECT SUMMARY/ABSTRACT There are approximately 500,000 childhood cancer survivors in the U.S. today. Childhood cancer survivors are vulnerable to late effects of therapy includin...
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any g...
Inflammation-induced cellular plasticity in pancreatic homeostasis and tumorigenesis
PROJECT SUMMARY Pancreatic cancer is a near universally fatal disease with a 5-year survival rate of less than 9%.As the third leading cause of cancer-related deaths in the United...
Inflammation-induced cellular plasticity in pancreatic homeostasis and tumorigenesis
PROJECT SUMMARY Pancreatic cancer is a near universally fatal disease with a 5-year survival rate of less than 9%. As the third leading cause of cancer-related deaths in the United...
Dissecting the mechanism of cabozantinib anti-tumor effect in renal cancer
PROJECT SUMMARY/ABSTRACT With 5-year survival rates of 10-15%, metastatic renal cell carcinoma (RCC) is largely incurable.Tyrosine kinase inhibitors (TKIs) are the largest and most...
Novel drug to treat poor prognosis AML
PROJECT SUMMARY/ABSTRACT The incidence of acute myeloid leukemia (AML) has been on the rise.Activating mutations in the fms like tyrosine kinase 3 (FLT3) are present in 25-30% of A...
A Fragment-Based Strategy for K-RAS Covalent Inhibitors
ABSTRACT KRAS is the most frequently mutated oncogene with mutation rates of 95% in pancreatic ductal adenocarcinoma (PDAC), 45% in colorectal cancer, and 30% in lung adenocarcinom...
Dissecting the mechanism of cabozantinib anti-tumor effect in renal cancer
PROJECT SUMMARY/ABSTRACT With 5-year survival rates of 10-15%, metastatic renal cell carcinoma (RCC) is largely incurable. Tyrosine kinase inhibitors (TKIs) are the largest and mos...
A Fragment-Based Strategy for K-RAS Covalent Inhibitors
ABSTRACT KRAS is the most frequently mutated oncogene with mutation rates of 95% in pancreatic ductal adenocarcinoma (PDAC), 45% in colorectal cancer, and 30% in lung adenocarcinom...
Novel drug to treat poor prognosis AML
PROJECT SUMMARY/ABSTRACT The incidence of acute myeloid leukemia (AML) has been on the rise. Activating mutations in the fms like tyrosine kinase 3 (FLT3) are present in 25-30% of...
Inflammation-induced cellular plasticity in pancreatic homeostasis and tumorigenesis
PROJECT SUMMARY Pancreatic cancer is a near universally fatal disease with a 5-year survival rate of less than 9%. As the third leading cause of cancer-related deaths in the United...
A Fragment-Based Strategy for K-RAS Covalent Inhibitors
ABSTRACT KRAS is the most frequently mutated oncogene with mutation rates of 95% in pancreatic ductal adenocarcinoma (PDAC), 45% in colorectal cancer, and 30% in lung adenocarcinom...