Browse All Grants
20,252 grants found
Showing 16,321 – 16,340 of 20,252 grants
Strategies to Disrupt Oncogenic Transcription in RCC Tumors
• PROJECT SUMMARY • Renal cell carcinoma (RCC) is the 8th most common form of adult cancer in the US. Despite recent improvement in treatment options, the majority of patients with...
Evolutionary trajectories of tumors following resistance to immune checkpoint blockade
PROJECT SUMMARY Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the majority of patients who receive ICB develop resistance and ultimately need to be trea...
Preclinical development of OR-449, a novel targeted therapy for adrenocortical cancer
ABSTRACT Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. The majority of cases are metastatic or locally advanced at diagnosis with a dismal five-year survival of
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
PROJECT SUMMARY/ABSTRACT: The goal of this project is to validate a clinically feasible, one-shot contrast-enhanced, multiparametric MRI approach for mapping the morphologic, hemod...
Metabolite driven mechanisms by which gut microbes impact checkpoint inhibitor success in non-small cell lung cancer patients
ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but clinical responses remain limited due to primary and/or acquired ICI resistance. Preliminary s...
Role of PRC1 in RUNX1-ETO-mediated transcriptional control
The goal of this application is to understand how the t(8;21), the most frequent chromosomal translocation associated with acute myeloid leukemia (AML), sets the stage for secondar...
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any g...
Patient-Generated Health Data to Predict Childhood Cancer Survivorship Outcomes
PROJECT SUMMARY/ABSTRACT There are approximately 500,000 childhood cancer survivors in the U.S. today.Childhood cancer survivors are vulnerable to late effects of therapy including...
Cancer Epigenetics Training (CET) Program
PROJECT SUMMARY This proposal seeks to develop a dedicated Cancer Epigenetics Training (CET) program at Van Andel Research Institute (VARI) to train two new postdoctoral fellows pe...
Metabolite driven mechanisms by which gut microbes impact checkpoint inhibitor success in non-small cell lung cancer patients
ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but clinical responses remain limited due to primary and/or acquired ICI resistance.Preliminary st...
Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer
PROJECT SUMMARY/ABSTRACT Advance care planning and palliative care represent evidence-based, high-quality care for patients with advanced cancer.Early identification of patients at...
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
1.Abstract Intensive curative chemotherapy is associated with subacute neurotoxicity, which can adversely affect brain functioning.These adverse treatment sequelae add to the signi...
E2F family transcription factors are directly regulated by TRIM28 to promote castration-resistance in prostate cancer
Prostate cancer (PCa) is the second-leading cause of cancer-related death in American men. Androgen deprivation therapies that target the androgen receptor (AR) are the mainstay tr...
Strategies to Disrupt Oncogenic Transcription in RCC Tumors
? PROJECT SUMMARY ? Renal cell carcinoma (RCC) is the 8th most common form of adult cancer in the US.Despite recent improvement in treatment options, the majority of patients with...
Patient-Generated Health Data to Predict Childhood Cancer Survivorship Outcomes
PROJECT SUMMARY/ABSTRACT There are approximately 500,000 childhood cancer survivors in the U.S. today. Childhood cancer survivors are vulnerable to late effects of therapy includin...
Cancer Epigenetics Training (CET) Program
PROJECT SUMMARY This proposal seeks to develop a dedicated Cancer Epigenetics Training (CET) program at Van Andel Research Institute (VARI) to train two new postdoctoral fellows pe...
Role of PRC1 in RUNX1-ETO-mediated transcriptional control
The goal of this application is to understand how the t(8;21), the most frequent chromosomal translocation associated with acute myeloid leukemia (AML), sets the stage for secondar...
Strategies to Disrupt Oncogenic Transcription in RCC Tumors
• PROJECT SUMMARY • Renal cell carcinoma (RCC) is the 8th most common form of adult cancer in the US. Despite recent improvement in treatment options, the majority of patients with...
Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer
PROJECT SUMMARY/ABSTRACT Advance care planning and palliative care represent evidence-based, high-quality care for patients with advanced cancer. Early identification of patients a...
Metabolite driven mechanisms by which gut microbes impact checkpoint inhibitor success in non-small cell lung cancer patients
ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but clinical responses remain limited due to primary and/or acquired ICI resistance. Preliminary s...