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20,252 grants found
Showing 16,301 – 16,320 of 20,252 grants
Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction
PROJECT SUMMARY Androgens are well known to be immunosuppressive, yet cancer immunotherapy is used without consideration of local androgen concentrations or the sex of the patient....
Novel noncanonical actions of CAR in human Liver
Project Summary The constitutive androstane receptor (CAR; NR1i3) is a well-established xenobiotic sensor that regulates the expression of numerous genes encoding proteins importan...
Inside-Out Nonlinear Gradients to Improve Diffusion MRI
Project Summary/Abstract The lifetime risk of prostate cancer is 1 in 9 and it remains the 2nd leading cancer killer of men. Yet many patients with low grade disease receive premat...
Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction
PROJECT SUMMARY Androgens are well known to be immunosuppressive, yet cancer immunotherapy is used without consideration of local androgen concentrations or the sex of the patient....
Precision Lung Cancer Survivorship Care Intervention: A Randomized Controlled Trial Serving Rural Survivors and Communities
PROJECT SUMMARY Among the devastating illnesses impacting rural America, few exact the physical, social, psychological, and economic toll of lung cancer. Lung cancer is the leading...
Novel noncanonical actions of CAR in human Liver
Project Summary The constitutive androstane receptor (CAR; NR1i3) is a well-established xenobiotic sensor that regulates the expression of numerous genes encoding proteins importan...
Inside-Out Nonlinear Gradients to Improve Diffusion MRI
Project Summary/Abstract The lifetime risk of prostate cancer is 1 in 9 and it remains the 2nd leading cancer killer of men. Yet many patients with low grade disease receive premat...
Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction
PROJECT SUMMARY Androgens are well known to be immunosuppressive, yet cancer immunotherapy is used without consideration of local androgen concentrations or the sex of the patient....
Precision Lung Cancer Survivorship Care Intervention: A Randomized Controlled Trial Serving Rural Survivors and Communities
PROJECT SUMMARY Among the devastating illnesses impacting rural America, few exact the physical, social, psychological, and economic toll of lung cancer.Lung cancer is the leading...
Role of PRC1 in RUNX1-ETO-mediated transcriptional control
The goal of this application is to understand how the t(8;21), the most frequent chromosomal translocation associated with acute myeloid leukemia (AML), sets the stage for secondar...
Evolutionary trajectories of tumors following resistance to immune checkpoint blockade
PROJECT SUMMARY Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the majority of patients who receive ICB develop resistance and ultimately need to be trea...
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
PROJECT SUMMARY/ABSTRACT: The goal of this project is to validate a clinically feasible, one-shot contrast-enhanced, multiparametric MRI approach for mapping the morphologic, hemod...
CSHL 2021 Conference on Biology of Cancer: Microenvironment and Metastasis
Biology of Cancer: Microenvironment & Metastasis Cold Spring Harbor, New York October 12 ? 16, 2021 ABSTRACT Cancer is now recognized as an abnormal organ where multiple cell t...
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome.RNAi molecules can, in theory, be designed against any ge...
Preclinical development of OR-449, a novel targeted therapy for adrenocortical cancer
ABSTRACT Adrenocortical carcinoma (ACC) is a rare, aggressive cancer. The majority of cases are metastatic or locally advanced at diagnosis with a dismal five-year survival of
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
1. Abstract Intensive curative chemotherapy is associated with subacute neurotoxicity, which can adversely affect brain functioning. These adverse treatment sequelae add to the sig...
Cancer Epigenetics Training (CET) Program
PROJECT SUMMARY This proposal seeks to develop a dedicated Cancer Epigenetics Training (CET) program at Van Andel Research Institute (VARI) to train two new postdoctoral fellows pe...
E2F family transcription factors are directly regulated by TRIM28 to promote castration-resistance in prostate cancer
Prostate cancer (PCa) is the second-leading cause of cancer-related death in American men. Androgen deprivation therapies that target the androgen receptor (AR) are the mainstay tr...
Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer
PROJECT SUMMARY/ABSTRACT Advance care planning and palliative care represent evidence-based, high-quality care for patients with advanced cancer. Early identification of patients a...
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any g...