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20,252 grants found
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The Role of Glutamine Metabolism in Monocyte-Derived Dendritic Cell Differentiation in the Soft-Tissue Sarcoma Microenvironment
PROJECT SUMMARY Soft-tissue sarcomas (STS) are a diverse and often fatal set of malignancies arising from connective tissue with a 16% five-year survival rate for metastatic diseas...
Genomic profiling of single circulating tumor cells in the precision medicine of metastatic prostate cancer
PROJECT SUMMARY AND ABSTRACT Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal state of prostate cancer (PCa) and remains as the most challenging issue in...
Reviving cancer immune surveillance with CD4 T cell help
Abstract The immune system is capable of eliminating advanced malignant tumors, yet cancer immunotherapy success has been limited to a subset of cancer types. Conventional CD4, or...
Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture
Project Summary/Abstract CD19-targeted chimeric antigen receptor (CAR) T cell therapy has shown remarkable treatment effects in B-cell malignancies, but many patients suffer from l...
Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2
Summary Glioblastoma multiforme (GBM) is the most aggressive and lethal of all brain tumors.Despite extensive efforts to improve treatment, current GBM therapy only marginally prol...
Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults
PROJECT SUMMARY/ABSTRACT HPV-infection is the most common sexually transmitted disease (STI), and it accounts for 70% of oropharyngeal cancers.People living with HIV (PLWH) are dis...
Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults
PROJECT SUMMARY/ABSTRACT HPV-infection is the most common sexually transmitted disease (STI), and it accounts for 70% of oropharyngeal cancers. People living with HIV (PLWH) are di...
Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture
Project Summary/Abstract CD19-targeted chimeric antigen receptor (CAR) T cell therapy has shown remarkable treatment effects in B-cell malignancies, but many patients suffer from l...
Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2
Summary Glioblastoma multiforme (GBM) is the most aggressive and lethal of all brain tumors. Despite extensive efforts to improve treatment, current GBM therapy only marginally pro...
Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults
PROJECT SUMMARY/ABSTRACT HPV-infection is the most common sexually transmitted disease (STI), and it accounts for 70% of oropharyngeal cancers. People living with HIV (PLWH) are di...
Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture
Project Summary/Abstract CD19-targeted chimeric antigen receptor (CAR) T cell therapy has shown remarkable treatment effects in B-cell malignancies, but many patients suffer from l...
Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2
Summary Glioblastoma multiforme (GBM) is the most aggressive and lethal of all brain tumors. Despite extensive efforts to improve treatment, current GBM therapy only marginally pro...
Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture
Project Summary/Abstract CD19-targeted chimeric antigen receptor (CAR) T cell therapy has shown remarkable treatment effects in B-cell malignancies, but many patients suffer from l...
Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2
Summary Glioblastoma multiforme (GBM) is the most aggressive and lethal of all brain tumors. Despite extensive efforts to improve treatment, current GBM therapy only marginally pro...
Novel noncanonical actions of CAR in human Liver
Project Summary The constitutive androstane receptor (CAR; NR1i3) is a well-established xenobiotic sensor that regulates the expression of numerous genes encoding proteins importan...
Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction
PROJECT SUMMARY Androgens are well known to be immunosuppressive, yet cancer immunotherapy is used without consideration of local androgen concentrations or the sex of the patient....
Inside-Out Nonlinear Gradients to Improve Diffusion MRI
Project Summary/Abstract The lifetime risk of prostate cancer is 1 in 9 and it remains the 2nd leading cancer killer of men.Yet many patients with low grade disease receive prematu...
Precision Lung Cancer Survivorship Care Intervention: A Randomized Controlled Trial Serving Rural Survivors and Communities
PROJECT SUMMARY Among the devastating illnesses impacting rural America, few exact the physical, social, psychological, and economic toll of lung cancer. Lung cancer is the leading...
Inside-Out Nonlinear Gradients to Improve Diffusion MRI
Project Summary/Abstract The lifetime risk of prostate cancer is 1 in 9 and it remains the 2nd leading cancer killer of men. Yet many patients with low grade disease receive premat...
Novel noncanonical actions of CAR in human Liver
Project Summary The constitutive androstane receptor (CAR; NR1i3) is a well-established xenobiotic sensor that regulates the expression of numerous genes encoding proteins importan...