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20,252 grants found
Showing 16,261 – 16,280 of 20,252 grants
Opioid-Sparing Interdisciplinary Interventions Addressing Pain in Head and Neck Cancer Patients
PROJECT SUMMARY BACKGROUND: For patients with head and neck cancer receiving radiation therapy (HNC), the frequency of substantial pain may be as high as 60 to 90% due to both the...
Impact of diagnostic peritoneal lavage on omentum metastasis
PROJECT SUMMARY/ABSTRACT The omentum is an immune cell-rich fatty tissue that suspends from the stomach and plays an important role in peritoneal defense.The omentum is the predomi...
Radiation and CSPG4-specifc CAR T cell based combinatorial therapy for the in vivo treatment of TNBC
Project Summary/Abstract Effective treatment options for triple negative breast cancer (TNBC) are lacking due to chemotherapy and radiation resistance and low therapeutic efficacy...
Novel models for functional profiling of germline SDH variants associated with cancer
Objectives: Loss-of-function (LOF) mutations in succinate dehydrogenase subunit (SDHx) genes result in SDH-deficiency and increase the lifetime risk for developing a number of canc...
Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools.
PROJECT SUMMARY Uveal melanoma (UM) is a rare melanoma subtype with an estimated annual incidence of approximately 2000 in the United States.While most patients have excellent rate...
Identifying and engaging a universal adjuvant for breaking macrophage immune tolerance in cancer
Project Summary/Abstract The ability of cancer cells to evade immunosurveillance is one of the hallmarks of cancer.Understanding the mechanisms by which T, B and NK cells detect an...
Preclinical Electron Paramagnetic Resonance Tumor Imager
Summary Revolutionary methods of acquiring electron paramagnetic resonance (EPR) spectra of free radicals create a paradigm shift in application of EPR to understanding the role of...
The Role of Glutamine Metabolism in Monocyte-Derived Dendritic Cell Differentiation in the Soft-Tissue Sarcoma Microenvironment
PROJECT SUMMARY Soft-tissue sarcomas (STS) are a diverse and often fatal set of malignancies arising from connective tissue with a 16% five-year survival rate for metastatic diseas...
Identifying and engaging a universal adjuvant for breaking macrophage immune tolerance in cancer
Project Summary/Abstract The ability of cancer cells to evade immunosurveillance is one of the hallmarks of cancer. Understanding the mechanisms by which T, B and NK cells detect a...
Genomic profiling of single circulating tumor cells in the precision medicine of metastatic prostate cancer
PROJECT SUMMARY AND ABSTRACT Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal state of prostate cancer (PCa) and remains as the most challenging issue in...
Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy
Project Summary Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical benefit in late-stage patients with melanoma, renal cell carcinoma, head and neck can...
Radiation and CSPG4-specifc CAR T cell based combinatorial therapy for the in vivo treatment of TNBC
Project Summary/Abstract Effective treatment options for triple negative breast cancer (TNBC) are lacking due to chemotherapy and radiation resistance and low therapeutic efficacy...
Novel models for functional profiling of germline SDH variants associated with cancer
Objectives: Loss-of-function (LOF) mutations in succinate dehydrogenase subunit (SDHx) genes result in SDH-deficiency and increase the lifetime risk for developing a number of canc...
Preclinical Electron Paramagnetic Resonance Tumor Imager
Summary Revolutionary methods of acquiring electron paramagnetic resonance (EPR) spectra of free radicals create a paradigm shift in application of EPR to understanding the role of...
Genome-wide Sequencing to Identify the Genes Responsible for Enchondromatoses and Related Malignant Tumors
Project Summary/Abstract We propose to investigate the molecular bases of Ollier disease (OD) and Maffucci syndrome (MS), rare diseases characterized by multiple enchondromas leadi...
Impact of diagnostic peritoneal lavage on omentum metastasis
PROJECT SUMMARY/ABSTRACT The omentum is an immune cell-rich fatty tissue that suspends from the stomach and plays an important role in peritoneal defense. The omentum is the predom...
The Role of Glutamine Metabolism in Monocyte-Derived Dendritic Cell Differentiation in the Soft-Tissue Sarcoma Microenvironment
PROJECT SUMMARY Soft-tissue sarcomas (STS) are a diverse and often fatal set of malignancies arising from connective tissue with a 16% five-year survival rate for metastatic diseas...
Preclinical Electron Paramagnetic Resonance Tumor Imager
Summary Revolutionary methods of acquiring electron paramagnetic resonance (EPR) spectra of free radicals create a paradigm shift in application of EPR to understanding the role of...
Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy
Project Summary Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical benefit in late-stage patients with melanoma, renal cell carcinoma, head and neck can...
Identifying and engaging a universal adjuvant for breaking macrophage immune tolerance in cancer
Project Summary/Abstract The ability of cancer cells to evade immunosurveillance is one of the hallmarks of cancer. Understanding the mechanisms by which T, B and NK cells detect a...