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20,252 grants found
Showing 16,241 – 16,260 of 20,252 grants
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
Abstract Cushing Disease (CD) is a life-threatening “orphan disease” caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma driving excess adrenal cortisol pro...
Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array
SUMMARY When selecting cancer therapy, physicians generally begin with first-line treatment options and monitor patient progress on a watch-and-wait basis, following a set of guide...
Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
PROJECT SUMMARY Chimeric antigen receptor (CAR)-engineered T cell therapy has revolutionized treatment for certain B cell malignancies, but similar successes for acute myeloid leuk...
Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem. High grade serou...
Targeting DKK-1 To Prevent Osteosarcoma Metastasis
Abstract Osteosarcoma is the most common primary bone tumor of adolescents and young adults. Aggressive surgery and intensive chemotherapy provide long term survival to up to 75% o...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease. A fundame...
Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem. High grade serou...
Genomic profiling of single circulating tumor cells in the precision medicine of metastatic prostate cancer
PROJECT SUMMARY AND ABSTRACT Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal state of prostate cancer (PCa) and remains as the most challenging issue in...
Identifying and engaging a universal adjuvant for breaking macrophage immune tolerance in cancer
Project Summary/Abstract The ability of cancer cells to evade immunosurveillance is one of the hallmarks of cancer. Understanding the mechanisms by which T, B and NK cells detect a...
Reviving cancer immune surveillance with CD4 T cell help
Abstract The immune system is capable of eliminating advanced malignant tumors, yet cancer immunotherapy success has been limited to a subset of cancer types. Conventional CD4, or...
Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy
Project Summary Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical benefit in late-stage patients with melanoma, renal cell carcinoma, head and neck can...
Genomic profiling of single circulating tumor cells in the precision medicine of metastatic prostate cancer
PROJECT SUMMARY AND ABSTRACT Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal state of prostate cancer (PCa) and remains as the most challenging issue in...
Genome-wide Sequencing to Identify the Genes Responsible for Enchondromatoses and Related Malignant Tumors
Project Summary/Abstract We propose to investigate the molecular bases of Ollier disease (OD) and Maffucci syndrome (MS), rare diseases characterized by multiple enchondromas leadi...
The Role of Glutamine Metabolism in Monocyte-Derived Dendritic Cell Differentiation in the Soft-Tissue Sarcoma Microenvironment
PROJECT SUMMARY Soft-tissue sarcomas (STS) are a diverse and often fatal set of malignancies arising from connective tissue with a 16% five-year survival rate for metastatic diseas...
Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy
Project Summary Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical benefit in late-stage patients with melanoma, renal cell carcinoma, head and neck can...
Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools.
PROJECT SUMMARY Uveal melanoma (UM) is a rare melanoma subtype with an estimated annual incidence of approximately 2000 in the United States. While most patients have excellent rat...
Opioid-Sparing Interdisciplinary Interventions Addressing Pain in Head and Neck Cancer Patients
PROJECT SUMMARY BACKGROUND: For patients with head and neck cancer receiving radiation therapy (HNC), the frequency of substantial pain may be as high as 60 to 90% due to both the...
Reviving cancer immune surveillance with CD4 T cell help
Abstract The immune system is capable of eliminating advanced malignant tumors, yet cancer immunotherapy success has been limited to a subset of cancer types. Conventional CD4, or...
Preclinical Electron Paramagnetic Resonance Tumor Imager
Summary Revolutionary methods of acquiring electron paramagnetic resonance (EPR) spectra of free radicals create a paradigm shift in application of EPR to understanding the role of...
Reviving cancer immune surveillance with CD4 T cell help
Abstract The immune system is capable of eliminating advanced malignant tumors, yet cancer immunotherapy success has been limited to a subset of cancer types.Conventional CD4, or `...