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20,252 grants found
Showing 16,221 – 16,240 of 20,252 grants
Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array
SUMMARY When selecting cancer therapy, physicians generally begin with first-line treatment options and monitor patient progress on a watch-and-wait basis, following a set of guide...
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
Abstract Cushing Disease (CD) is a life-threatening ?orphan disease? caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma driving excess adrenal cortisol pro...
Testing in-situ formed nanofibers for inhibiting metastatic osteosarcoma (mOS) in murine models
Abstract The treatment outcome of metastatic osteosarcoma (mOS) remains poor and has not improved for over four decades. Thus, developing novel approaches for treating mOS is urgen...
Targeting DKK-1 To Prevent Osteosarcoma Metastasis
Abstract Osteosarcoma is the most common primary bone tumor of adolescents and young adults. Aggressive surgery and intensive chemotherapy provide long term survival to up to 75% o...
Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
PROJECT SUMMARY Chimeric antigen receptor (CAR)-engineered T cell therapy has revolutionized treatment for certain B cell malignancies, but similar successes for acute myeloid leuk...
Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array
SUMMARY When selecting cancer therapy, physicians generally begin with first-line treatment options and monitor patient progress on a watch-and-wait basis, following a set of guide...
Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem. High grade serou...
Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
PROJECT SUMMARY Chimeric antigen receptor (CAR)-engineered T cell therapy has revolutionized treatment for certain B cell malignancies, but similar successes for acute myeloid leuk...
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
Abstract Cushing Disease (CD) is a life-threatening “orphan disease” caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma driving excess adrenal cortisol pro...
Determining the role of ASCL1 in neuroendocrine prostate cancer
Most patients with prostate adenocarcinoma, an androgen receptor (AR) driven cancer, develop castrate resistant prostate cancer (CRPC) due to resistance to first-line androgen depr...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease. A fundame...
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
Abstract Cushing Disease (CD) is a life-threatening “orphan disease” caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma driving excess adrenal cortisol pro...
Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
PROJECT SUMMARY Chimeric antigen receptor (CAR)-engineered T cell therapy has revolutionized treatment for certain B cell malignancies, but similar successes for acute myeloid leuk...
Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem. High grade serou...
Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array
SUMMARY When selecting cancer therapy, physicians generally begin with first-line treatment options and monitor patient progress on a watch-and-wait basis, following a set of guide...
Determining the role of ASCL1 in neuroendocrine prostate cancer
Most patients with prostate adenocarcinoma, an androgen receptor (AR) driven cancer, develop castrate resistant prostate cancer (CRPC) due to resistance to first-line androgen depr...
Targeting DKK-1 To Prevent Osteosarcoma Metastasis
Abstract Osteosarcoma is the most common primary bone tumor of adolescents and young adults. Aggressive surgery and intensive chemotherapy provide long term survival to up to 75% o...
Diversity Supplement - Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem. High grade serou...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease. A fundame...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease. A fundame...