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20,252 grants found
Showing 16,201 – 16,220 of 20,252 grants
Mechanisms by which of GPCR Signaling Inhibits Acute Myeloid Leukemia
Project Summary: Despite recent advances in cancer therapy the 5-year overall survival rate of Acute Myeloid Leukemia (AML) remains around 30%.The first line standard of care thera...
Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal and is projected to become the second-leading cause of cancer related deaths in the US by 2030....
Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors
Approximately 90% of pediatric central nervous system tumor (CNST) survivors, treated with radiotherapy, experience radiotherapy-induced brain injury (RIBI) and neurocognitive decl...
Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal and is projected to become the second-leading cause of cancer related deaths in the US by 2030....
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors
Approximately 90% of pediatric central nervous system tumor (CNST) survivors, treated with radiotherapy, experience radiotherapy-induced brain injury (RIBI) and neurocognitive decl...
Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal and is projected to become the second-leading cause of cancer related deaths in the US by 2030....
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Neutrophil Extracellular Traps and the Intersection of the Immune and Biophysical Microenvironments
Project Summary: While immunotherapy has revolutionized cancer treatment in recent years, major challenges still remain.Metastatic cancer remains difficult to treat, resulting in 9...
Neutrophil Extracellular Traps and the Intersection of the Immune and Biophysical Microenvironments
Project Summary: While immunotherapy has revolutionized cancer treatment in recent years, major challenges still remain. Metastatic cancer remains difficult to treat, resulting in...
Neutrophil Extracellular Traps and the Intersection of the Immune and Biophysical Microenvironments
Project Summary: While immunotherapy has revolutionized cancer treatment in recent years, major challenges still remain. Metastatic cancer remains difficult to treat, resulting in...
Targeting mitochondrial adaptations to suppress metastatic outgrowth in serous ovarian cancer
PROJECT SUMMARY Serous ovarian cancer is the 5th leading cause of cancer-related deaths in women, with a 30% survival rate when spread into the highly hypoxic and visceral peritone...
Determining the role of ASCL1 in neuroendocrine prostate cancer
Most patients with prostate adenocarcinoma, an androgen receptor (AR) driven cancer, develop castrate resistant prostate cancer (CRPC) due to resistance to first-line androgen depr...
Effects of tumor-microbial interactions on EGFR-targeted therapy resistance in lung cancer
PROJECT SUMMARY/ABSTRACT We are in desperate need of novel therapies for treating lung cancer, particularly ones that can overcome treatment resistance. Intra-tumoral bacteria are...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease. A fundame...
Histone Deacetylation Signaling in Aging and Cancer Pathways
Our broad research goal is to understand chromatin regulatory mechanisms in nuclear and epigenetic programs and how these mechanisms are deregulated in aging and disease.A fundamen...
Targeting Wnt signaling in therapy-resistant ovarian cancer
PROJECT SUMMARY PARP inhibitor (PARPi) use in the clinic is expanding into multiple cancer types, and consequently, PARPi resistance is a growing clinical problem.High grade serous...
Targeting DKK-1 To Prevent Osteosarcoma Metastasis
Abstract Osteosarcoma is the most common primary bone tumor of adolescents and young adults.Aggressive surgery and intensive chemotherapy provide long term survival to up to 75% of...
Effects of tumor-microbial interactions on EGFR-targeted therapy resistance in lung cancer
PROJECT SUMMARY/ABSTRACT We are in desperate need of novel therapies for treating lung cancer, particularly ones that can overcome treatment resistance. Intra-tumoral bacteria are...
Testing in-situ formed nanofibers for inhibiting metastatic osteosarcoma (mOS) in murine models
Abstract The treatment outcome of metastatic osteosarcoma (mOS) remains poor and has not improved for over four decades. Thus, developing novel approaches for treating mOS is urgen...