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20,252 grants found
Showing 16,181 – 16,200 of 20,252 grants
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
ABSTRACT Nanoparticle-based technologies including theranostic nanomedicine are fast developing areas of biomedical research offering unprecedented potential for cancer treatment....
Structure, function, and application of novel antagonists of the intrinsically disordered androgen receptor amino-terminal domain as imaging agents and therapeutics
Project Summary Newer therapies directed at the full-length (FL) androgen receptor (AR) C-terminal ligand-binding domain (LBD) such as abiraterone and enzalutamide provide survival...
Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient
PROJECT SUMMARY Tobacco use causes at least 12 types of cancer and is responsible for 30% of all cancer deaths in the United States. Quitting smoking is the single most effective a...
Identification and molecular characterization of FGFR4 p.G388R variant signaling in cerebellar hemangioblastomas
PROJECT SUMMARY Histologically characterized by neoplastic stromal cells and abundant vasculature, hemangioblastomas (HBs) occur as sporadic lesions (~70%, predominantly in the cer...
Targeting pyrimidine biosynthesis in pancreatic ductal adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal and is projected to become the second-leading cause of cancer related deaths in the US by 2030....
Mechanisms by which of GPCR Signaling Inhibits Acute Myeloid Leukemia
Project Summary: Despite recent advances in cancer therapy the 5-year overall survival rate of Acute Myeloid Leukemia (AML) remains around 30%. The first line standard of care ther...
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Elucidating the role of intratumoral microbiota on immunotherapy efficacy
PROJECT SUMMARY/ABSTRACT Microbes live in primary tumors across organ systems and in tumor metastases, making the microbes an intrinsic and essential component of the tumor microen...
Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer
Summary The PI3K/Akt signaling is one of most important oncogenic events in human cancers. It regulates many aspects of biological functions including cell proliferation, survival,...
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors
Approximately 90% of pediatric central nervous system tumor (CNST) survivors, treated with radiotherapy, experience radiotherapy-induced brain injury (RIBI) and neurocognitive decl...
Elucidating the role of intratumoral microbiota on immunotherapy efficacy
PROJECT SUMMARY/ABSTRACT Microbes live in primary tumors across organ systems and in tumor metastases, making the microbes an intrinsic and essential component of the tumor microen...
Discovery of epidermal/dermal targeting formulations for cutaneous squamous cell carcinoma
The incidence and mortality rates of cutaneous squamous cell carcinoma (cSCC) and skin cancer continues to increase. It is expected that 1 in 5 Americans will develop skin cancer i...
Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors
Approximately 90% of pediatric central nervous system tumor (CNST) survivors, treated with radiotherapy, experience radiotherapy-induced brain injury (RIBI) and neurocognitive decl...
Developing CDK12 inhibitors to overcome therapy resistance in HER2+ and KRAS driven breast and lung cancers
Project Summary Although the development of targeted therapies has improved overall cancer patient survival, adaptive responses by tumor cells can render these treatments ineffecti...
Identification and molecular characterization of FGFR4 p.G388R variant signaling in cerebellar hemangioblastomas
PROJECT SUMMARY Histologically characterized by neoplastic stromal cells and abundant vasculature, hemangioblastomas (HBs) occur as sporadic lesions (~70%, predominantly in the cer...
Regulation of oncogenic Akt ubiquitination and activation by diverse mechanisms in cancer
Summary The PI3K/Akt signaling is one of most important oncogenic events in human cancers.It regulates many aspects of biological functions including cell proliferation, survival,...
Building capacity for clinical trial improvement through implementation science
PROJECT SUMMARY Each year, cancer centers invest millions of dollars into ?intramural trials??institutional clinical trials funded to complement larger scale cooperative group, ind...