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20,252 grants found
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Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy
PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwid...
Use of Noninvasive Biomarkers and Advanced MRI for early detection of NF1-associated MPNSTs
ABSTRACT Approximately 120,000 Americans with neurofibromatosis type I (NF1) suffer a constellation of clinical manifestations, including aberrant proliferation of neural tissues l...
CAPRI: Columbia Cancer Research Training Program for Resident-Investigators
Project Summary/Abstract This is a proposal to fund an established post-doctoral training program called the Columbia Cancer Research Training Program for Resident-Investigators (C...
Acupuncture to Improve Outcomes in Patients with Sepsis: a Randomized Controlled Trial
PROJECT SUMMARY/ABSTRACT: Sepsis is a life-threatening medical condition characterized by high levels of inflammatory markers and multi-organ damage. Despite standard treatment, se...
Understanding Pancreatic Cancer Immune Microenvironment and Treatment Response through Integrating in vivo Imaging with Immunophenotyping
Project Summary Although cancer immunotherapy has been proclaimed a breakthrough in many types of cancer, pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoi...
Translational Combinations of Nanocarriers and Blockers for Metastatic Breast Cancer
ABSTRACT Metastasis contributes to the vast majority of breast cancer deaths but current therapies for disseminated disease have limited efficacy and significant side effects. Immu...
Reprogramming T cell function with multiplexed genome engineering to develop next-generation immunotherapy
Project Summary: Adoptive cellular immunotherapy utilizing T cells engineered with chimeric antigen receptor (CAR) has shown durable clinical responses in hematologic malignancies....
Training clinicians in the integration of technology with cancer supportive care
PROGRAM SUMMARY Recent epidemiologic evidence highlights the significant unmet behavioral health needs of cancer patients in the United States. A strong evidence base now supports...
Fidelity Mechanisms of DNA Polymerase Beta
PROJECT SUMMARY/ABSTRACT Mutations in the human genome give rise to many human diseases including cancer. Mutations are also beneficial for processes including evolution and adapti...
High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics
Abstract Digital assays — in which ultra-sensitive molecular measurements are made by performing millions of parallel experiments in picoliter droplets — have generated much recent...
2024 DNA Damage, Mutation and Cancer Gordon Research Conference and Seminar
SUMMARY. The DNA Damage, Mutation and Cancer Gordon Research Conference (GRC) is a leading international scientific conference focused on advancing science through the presentation...
Mechanisms of Th17-DC immunotherapy for ovarian cancer
The clinical experience with anti-PD-1 immune checkpoint inhibition in ovarian cancer has been disappointing. The poor outcomes may at least in part be due to the highly immunosupp...
Proximity epigenomics for context-specific analysis of complex chromatin features
Project Summary Chromatin context defines all DNA transactions, from gene regulation to genome maintenance. Changes in chromatin composition are hallmarks of cancer cells that cont...
Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis
Pancreatic ductal adenocarincomas (PDAC) is an aggressive disease with poor prognosis and is characterized by a unique microenvironment that is severely depleted of amino acids (AA...
Discovery and anti-tumor activity of the first antagonists targeting human Sonic Hedgehog autoprocessing
ABSTRACT We are pursuing the first anti-tumor small molecules that act specifically against human Sonic Hh protein autoprocessing, a unique biosynthetic event that is necessary to...
Development of immunocompetent melanoma brain metastases organoids
Abstract Immune checkpoint inhibition (ICI) can control intracranial disease in approximately 50% of patients with melanoma brain metastases (MBM), which is the leading cause of de...
Characterizing the sources, mechanisms, and translational relevance of microbial TMAO in driving anti-tumor immunity in pancreatic cancer.
PROJECT SUMMARY The treatment of pancreatic ductal adenocarcinoma (PDAC) remains a major hurdle with 5-year survival of 12%. PDAC resistance to chemotherapy and immunotherapy is th...
Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis - Diversity Supplement
Pancreatic ductal adenocarincomas (PDAC) is an aggressive disease with poor prognosis and is characterized by a unique microenvironment that is severely depleted of amino acids (AA...
Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging
Abstract To survive in the nutrient- and oxygen-deprived niche, cancer cells undergo a drastic metabolic reprogramming where they upregulate their endogenous lipid synthesis and ex...
Investigating the Molecular Determinants Driving Response and Resistance to HDAC6 Targeted Therapy in Breast Cancer
SUMMARY We previously reported that the viability of some breast cancers depends on histone deacetylase 6 (HDAC6). We also developed a biomarker (HDAC6-score, validated with a NY C...