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Showing 16,16116,180 of 20,252 grants

Completed NON-SBIR/STTR RPGS
Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
NATIONAL CANCER INSTITUTE H. Lee Moffitt Cancer Ctr & Res Inst United States 2021 – 2025

In the field of tumor immunology, while the generation and maintenance of anti-tumor CD8 T cell memory responses are considered crucial for the long-term host survival, the basic t...

$3.69M
USD
Completed NON-SBIR/STTR RPGS
Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
NATIONAL CANCER INSTITUTE H. Lee Moffitt Cancer Ctr & Res Inst United States 2021 – 2025

In the field of tumor immunology, while the generation and maintenance of anti-tumor CD8 T cell memory responses are considered crucial for the long-term host survival, the basic t...

$3.45M
USD
Completed TRAINING, INDIVIDUAL
The role of UTX in Epidermal Homeostasis, Carcinogenesis, and Sex Mediated Risk of Cutaneous Squamous Cell Carcinoma
NATIONAL CANCER INSTITUTE University of Pennsylvania United States 2021 – 2024

ABSTRACT Histone modifiers are amongst the most highly mutated genes in all forms of cancer, with the histone demethylase UTX (KDM6A) being one of the most frequent. UTX is mutated...

$467.5K
USD
Completed NON-SBIR/STTR RPGS
Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
NATIONAL CANCER INSTITUTE H. Lee Moffitt Cancer Ctr & Res Inst United States 2021 – 2025

In the field of tumor immunology, while the generation and maintenance of anti-tumor CD8 T cell memory responses are considered crucial for the long-term host survival, the basic t...

$3.69M
USD
Completed TRAINING, INDIVIDUAL
The role of UTX in Epidermal Homeostasis, Carcinogenesis, and Sex Mediated Risk of Cutaneous Squamous Cell Carcinoma
NATIONAL CANCER INSTITUTE University of Pennsylvania United States 2021 – 2024

ABSTRACT Histone modifiers are amongst the most highly mutated genes in all forms of cancer, with the histone demethylase UTX (KDM6A) being one of the most frequent. UTX is mutated...

$351.3K
USD
Completed NON-SBIR/STTR RPGS
Study of Anti-Tumor Immunity and Tissue Resident Memory Cell Development by NKG2D and Ribosomal Protein S6 Signaling in T cells
NATIONAL CANCER INSTITUTE H. Lee Moffitt Cancer Ctr & Res Inst United States 2021 – 2025

In the field of tumor immunology, while the generation and maintenance of anti-tumor CD8 T cell memory responses are considered crucial for the long-term host survival, the basic t...

$3.58M
USD
Active OTHER RESEARCH-RELATED
The Role of MYC Mutations in acute Myeloid Leukemia
NATIONAL CANCER INSTITUTE Washington University United States 2021 – 2026

Project Summary This proposal outlines a 5-year research and career development plan designed to support the candidate’s trajectory towards an independent academic career. The prop...

$2.25M
USD
Active NON-SBIR/STTR RPGS
Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient
NATIONAL CANCER INSTITUTE Yale University United States 2021 – 2026

PROJECT SUMMARY Tobacco use causes at least 12 types of cancer and is responsible for 30% of all cancer deaths in the United States. Quitting smoking is the single most effective a...

$7.51M
USD
Completed SBIR-STTR RPGS
Therapeutic antibody for cancer-associated cachexia
NATIONAL CANCER INSTITUTE Larix Bioscience, Llc United States 2021 – 2023

Therapeutic antibody for cancer-associated cachexia Abstract Cachexia is a debilitating, wasting disease, characterized by loss of appetite, skeletal muscle, and fat mass.Cancer-as...

$2.52M
USD
Active NON-SBIR/STTR RPGS
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
NATIONAL CANCER INSTITUTE Michigan State University United States 2021 – 2026

ABSTRACT Nanoparticle-based technologies including theranostic nanomedicine are fast developing areas of biomedical research offering unprecedented potential for cancer treatment.T...

$5.68M
USD
Completed NON-SBIR/STTR RPGS
Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient
NATIONAL CANCER INSTITUTE Northeastern University United States 2021 – 2021

PROJECT SUMMARY Tobacco use causes at least 12 types of cancer and is responsible for 30% of all cancer deaths in the United States.Quitting smoking is the single most effective ap...

$10
USD
Active NON-SBIR/STTR RPGS
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
NATIONAL CANCER INSTITUTE Michigan State University United States 2021 – 2026

ABSTRACT Nanoparticle-based technologies including theranostic nanomedicine are fast developing areas of biomedical research offering unprecedented potential for cancer treatment....

$5.4M
USD
Active NON-SBIR/STTR RPGS
Structure, function, and application of novel antagonists of the intrinsically disordered androgen receptor amino-terminal domain as imaging agents and therapeutics
NATIONAL CANCER INSTITUTE Provincial Health Services Authority Canada 2021 – 2026

Project Summary Newer therapies directed at the full-length (FL) androgen receptor (AR) C-terminal ligand-binding domain (LBD) such as abiraterone and enzalutamide provide survival...

$4.24M
USD
Active NON-SBIR/STTR RPGS
Structure, function, and application of novel antagonists of the intrinsically disordered androgen receptor amino-terminal domain as imaging agents and therapeutics
NATIONAL CANCER INSTITUTE Provincial Health Services Authority Canada 2021 – 2026

Project Summary Newer therapies directed at the full-length (FL) androgen receptor (AR) C-terminal ligand-binding domain (LBD) such as abiraterone and enzalutamide provide survival...

$4.43M
USD
Active OTHER RESEARCH-RELATED
The Role of MYC Mutations in acute Myeloid Leukemia
NATIONAL CANCER INSTITUTE Washington University United States 2021 – 2026

Project Summary This proposal outlines a 5-year research and career development plan designed to support the candidate?s trajectory towards an independent academic career.The propo...

$2.25M
USD
Active NON-SBIR/STTR RPGS
Structure, function, and application of novel antagonists of the intrinsically disordered androgen receptor amino-terminal domain as imaging agents and therapeutics
NATIONAL CANCER INSTITUTE Provincial Health Services Authority Canada 2021 – 2026

Project Summary Newer therapies directed at the full-length (FL) androgen receptor (AR) C-terminal ligand-binding domain (LBD) such as abiraterone and enzalutamide provide survival...

$4.33M
USD
Active NON-SBIR/STTR RPGS
Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient
NATIONAL CANCER INSTITUTE Yale University United States 2021 – 2026

PROJECT SUMMARY Tobacco use causes at least 12 types of cancer and is responsible for 30% of all cancer deaths in the United States. Quitting smoking is the single most effective a...

$6.37M
USD
Active OTHER RESEARCH-RELATED
The Role of MYC Mutations in acute Myeloid Leukemia
NATIONAL CANCER INSTITUTE Washington University United States 2021 – 2026

Project Summary This proposal outlines a 5-year research and career development plan designed to support the candidate’s trajectory towards an independent academic career. The prop...

$2.25M
USD
Active NON-SBIR/STTR RPGS
anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals
NATIONAL CANCER INSTITUTE Michigan State University United States 2021 – 2026

ABSTRACT Nanoparticle-based technologies including theranostic nanomedicine are fast developing areas of biomedical research offering unprecedented potential for cancer treatment....

$5.57M
USD
Active OTHER RESEARCH-RELATED
The Role of MYC Mutations in acute Myeloid Leukemia
NATIONAL CANCER INSTITUTE Washington University United States 2021 – 2026

Project Summary This proposal outlines a 5-year research and career development plan designed to support the candidate’s trajectory towards an independent academic career. The prop...

$2.25M
USD