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20,252 grants found
Showing 16,101 – 16,120 of 20,252 grants
Empirical testing of a widely available insurance-based monetary incentive program for exercise: A randomized trial
Participation in regular physical activity (PA) has numerous health benefits including reduced risk of all-cause mortality,1-7 cardiovascular disease,8-12 diabetes,13-16 and cancer...
Role of type 2 immune response in pancreatic cancer tumorigenesis
Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that remains largely incurable.Although the cause for this profound therapeutic resistance is poor...
The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor
Project Summary/Abstract Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neoplasms with increasing incidence and ill-defined pathobiology....
Improving cancer health equity by targeting physician networks
PROJECT SUMMARY Disparities in outcomes among cancer patients who are rural-residing, with lower SES, and a racial minority are well-documented and have garnered significant nation...
Brain iron accumulation as an in vivo quantifiable biomarker of neurocognitive dysfunction in pediatric brain tumor survivors
Primary brain tumors are the most common solid tumors and the leading cause of death from childhood cancer. In the era of molecular targeted therapy, greater than 60% of children w...
Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial
Project Summary/Abstract A priority in oncology and palliative care is preparing the 3.2 million U.S. family caregivers of persons with cancer to effectively support patients in he...
Empirical testing of a widely available insurance-based monetary incentive program for exercise: A randomized trial
Participation in regular physical activity (PA) has numerous health benefits including reduced risk of all-cause mortality,1-7 cardiovascular disease,8-12 diabetes,13-16 and cancer...
A non-canonical role for EZH2 in rRNA methtlation
Background: Mounting evidence suggests that dysregulated epigenetic modifications play a crucial role in cancer initiation, progression, and metastasis. Epigenetic regulations incl...
Role of ctDNA change as a response measure in the EA1183 patient population and how ctDNA changes correlate with metabolic response by serial FDG PET/CT
Project Summary: Patients with bone dominant (BD) and bone only (BO) metastatic breast cancer (MBC) represent a large patient population1,2 who are often excluded from clinical tri...
Assessing the long-term impacts of the COVID-19 pandemic on disparities in cancer screening and follow-up
PROJECT SUMMARY/ABSTRACT: The COVID-19 pandemic has led to dramatic reductions in cancer screening and follow-up services. During the early months of the pandemic, national organiz...
Exploration of Novel Mutation Biomarkers to Repurpose EGFRi for Mutant KRAS Colorectal Cancer
PROJECT SUMMARY/ABSTRACT Metastatic colorectal cancer (CRC) has very poor prognosis with median survival of less than 36 months. The epidermal growth factor receptor (EGFR) is a ma...
Understanding the Contribution of Colorectal Cancer Tumor Characteristics to Disparities in Colorectal Cancer Survival
PROJECT ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer death among U.S. men and women. Racial disparities in CRC survival exist, where the CRC mortality rat...
Role of type 2 immune response in pancreatic cancer tumorigenesis
Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that remains largely incurable. Although the cause for this profound therapeutic resistance is poo...
Optimizing Lung Cancer Screening in Cancer Survivors
The goal of the proposal is to identify optimal lung cancer (LC) screening strategies for breast (BC), prostate (PC), colorectal (CRC) cancer survivors. We will accomplish these go...
The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor
Project Summary/Abstract Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neoplasms with increasing incidence and ill-defined pathobiology....
The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor
Project Summary/Abstract Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) are a heterogeneous group of neoplasms with increasing incidence and ill-defined pathobiology....
Lipid Metabolism in Liver Cancer
Project Summary Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide, with 5- year survival less than 12%. Paralleling the increased inc...
Role of type 2 immune response in pancreatic cancer tumorigenesis
Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that remains largely incurable. Although the cause for this profound therapeutic resistance is poo...
Exploration of Novel Mutation Biomarkers to Repurpose EGFRi for Mutant KRAS Colorectal Cancer
PROJECT SUMMARY/ABSTRACT Metastatic colorectal cancer (CRC) has very poor prognosis with median survival of less than 36 months. The epidermal growth factor receptor (EGFR) is a ma...
Role of ctDNA change as a response measure in the EA1183 patient population and how ctDNA changes correlate with metabolic response by serial FDG PET/CT
Project Summary: Patients with bone dominant (BD) and bone only (BO) metastatic breast cancer (MBC) represent a large patient population1,2 who are often excluded from clinical tri...