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20,252 grants found
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Transdisciplinary Conference for Future Leaders in Precision Public Health
PROJECT SUMMARY Increasingly, genomics is being integrated into population-level cancer prevention and control approaches through precision public health. Given that the field is s...
Helicobacter Infection and Liver Cancer Risk among African Americans and Whites in the United States
Project Summary Liver cancer in the U.S. has tripled since the 1980s and is now among the leading causes of cancer deaths.Although hepatitis B virus (HBV) and hepatitis C virus (HC...
Transdisciplinary Conference for Future Leaders in Precision Public Health
PROJECT SUMMARY Increasingly, genomics is being integrated into population-level cancer prevention and control approaches through precision public health. Given that the field is s...
An integrative multi-omics approach to characterize prostate cancer risk in diverse populations
PROJECT SUMMARY In the US, prostate cancer (PCa) is the second leading cause of cancer death in men, with men of African ancestry having the highest incidence and mortality rates....
Personalized Motion Management for Truly 4D Lung Radiotherapy
It is well-recognized that unanticipated respiration-induced motion can result in significant errors in planned vs delivered dose in thoracic radiotherapy (RT), resulting in local...
Are racial disparities in colon cancer due to epigenetic outliers.
Racial disparities in the incidence and mortality of colon cancer exist, with African Americans being the most negatively affected group. The disproportionate impact of colon cance...
The regulation of innate immune sensors to control GVHD and GVL after allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (aHSCT) is a potentially curative therapy used to treat several malignant diseases, of which the most frequent is acute myeloid l...
Assessing the long-term impacts of the COVID-19 pandemic on disparities in cancer screening and follow-up
PROJECT SUMMARY/ABSTRACT: The COVID-19 pandemic has led to dramatic reductions in cancer screening and follow-up services. During the early months of the pandemic, national organiz...
Role of type 2 immune response in pancreatic cancer tumorigenesis
Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that remains largely incurable. Although the cause for this profound therapeutic resistance is poo...
Multilevel Interventions to Increase Adherence to Lung Cancer Screening
ABSTRACT Screening for lung cancer has the potential for a profound public health benefit. Lung cancer is the leading cause of US cancer morbidity and mortality for both men and wo...
Empirical testing of a widely available insurance-based monetary incentive program for exercise: A randomized trial
Participation in regular physical activity (PA) has numerous health benefits including reduced risk of all-cause mortality,1-7 cardiovascular disease,8-12 diabetes,13-16 and cancer...
A non-canonical role for EZH2 in rRNA methtlation
Background: Mounting evidence suggests that dysregulated epigenetic modifications play a crucial role in cancer initiation, progression, and metastasis. Epigenetic regulations incl...
Brain iron accumulation as an in vivo quantifiable biomarker of neurocognitive dysfunction in pediatric brain tumor survivors
Primary brain tumors are the most common solid tumors and the leading cause of death from childhood cancer.In the era of molecular targeted therapy, greater than 60% of children wi...
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung Cancer
Project Summary / Abstract Non-small cell lung cancer (NSCLC) is one of the most common causes of cancer death in the USA and despite recent advances, the overall 5-year survival r...
Effectiveness and Mechanisms of Multilevel Implementation Strategies to Improve Provider Recommendation and Advance HPV Vaccination: a Cluster Randomized Trial
Project Abstract Millions of US teens remain at risk of developing human papillomavirus (HPV)-related cancers due to inadequate HPV vaccine uptake, despite strong endorsement in cl...
Role of ctDNA change as a response measure in the EA1183 patient population and how ctDNA changes correlate with metabolic response by serial FDG PET/CT
Project Summary: Patients with bone dominant (BD) and bone only (BO) metastatic breast cancer (MBC) represent a large patient population1,2 who are often excluded from clinical tri...
Understanding the Contribution of Colorectal Cancer Tumor Characteristics to Disparities in Colorectal Cancer Survival
PROJECT ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer death among U.S. men and women. Racial disparities in CRC survival exist, where the CRC mortality rat...
Lipid Metabolism in Liver Cancer
Project Summary Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide, with 5- year survival less than 12%. Paralleling the increased inc...
Empirical testing of a widely available insurance-based monetary incentive program for exercise: A randomized trial
Participation in regular physical activity (PA) has numerous health benefits including reduced risk of all-cause mortality,1-7 cardiovascular disease,8-12 diabetes,13-16 and cancer...
Lipid Metabolism in Liver Cancer
Project Summary Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide, with 5- year survival less than 12%.Paralleling the increased inci...