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20,252 grants found
Showing 16,041 – 16,060 of 20,252 grants
PRECISION METABOLIC THERAPY OF p53 MUTANT TRIPLE NEGATIVE BREAST CANCERS
PROJECT SUMMARY The Cancer Genome Atlas (TCGA) studies have identified p53 as the most frequently mutated gene in breast cancer. In particular, 80% of triple-negative breast cancer...
Optical Surface Applicator Light Dosimetry for Ruthenium-based Photosensitizer Mediated Intraoperative Photodynamic Therapy
SUMMARY Patients with non-small cell lung cancer (NSCLC) with pleural dissemination face a dire prognosis.Several clinical studies reported that adding intraoperative photodynamic...
Optical Surface Applicator Light Dosimetry for Ruthenium-based Photosensitizer Mediated Intraoperative Photodynamic Therapy
SUMMARY Patients with non-small cell lung cancer (NSCLC) with pleural dissemination face a dire prognosis. Several clinical studies reported that adding intraoperative photodynamic...
T-cell engaging bispecific antibodies designed for proteolytic activation in the tumor microenvironment
PROJECT SUMMARY In response to NCI’s FOA PAR-20-292 for early and conceptual stages of translational cancer research, our NIH R21 grant application seeks the generation and validat...
A New Class of Magnetic Nanoparticles for Glioma Targeted Drug Delivery
Project Summary Glioblastoma is the most common and aggressive malignant brain tumor with extremely poor prognosis.Current standard care for glioblastoma treatment consists of maxi...
Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities
The recent success and expanded use of the checkpoint inhibitor immunotherapies in clinical oncology has resulted in an increased incidence of a variety of immune-related adverse e...
PRECISION METABOLIC THERAPY OF p53 MUTANT TRIPLE NEGATIVE BREAST CANCERS
PROJECT SUMMARY The Cancer Genome Atlas (TCGA) studies have identified p53 as the most frequently mutated gene in breast cancer. In particular, 80% of triple-negative breast cancer...
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide, causing over 700,000 deaths annually. In the US, HCC rates have tripled in the last three d...
Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities
The recent success and expanded use of the checkpoint inhibitor immunotherapies in clinical oncology has resulted in an increased incidence of a variety of immune-related adverse e...
Tumor-promoting and tumor-suppressive roles of Hepatic Stellate Cell Subpopulations in NASH-HCC
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide, causing over 700,000 deaths annually. In the US, HCC rates have tripled in the last three d...
PRECISION METABOLIC THERAPY OF p53 MUTANT TRIPLE NEGATIVE BREAST CANCERS
PROJECT SUMMARY The Cancer Genome Atlas (TCGA) studies have identified p53 as the most frequently mutated gene in breast cancer. In particular, 80% of triple-negative breast cancer...
Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities
The recent success and expanded use of the checkpoint inhibitor immunotherapies in clinical oncology has resulted in an increased incidence of a variety of immune-related adverse e...
Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple Myeloma
PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals.The goal of this Fast-Track STTR is to develop a new specifi...
Evaluating the impact of e-cigarette social media marketing on e-cigarette use among underage youth.
Abstract/Project summary E-cigarettes are a big problem among high school students – with rates of daily use exploding from 12% in 2017 to 28% in 2019. Adolescents are exposed to e...
Evaluating the impact of e-cigarette social media marketing on e-cigarette use among underage youth.
Abstract/Project summary E-cigarettes are a big problem among high school students – with rates of daily use exploding from 12% in 2017 to 28% in 2019. Adolescents are exposed to e...
NYU Melanoma SPORE
OVERALL PROJECT SUMMARY The impressive clinical successes in immune checkpoint inhibition (ICI) therapy over the last decade have not been matched by the development of clinically...
Admin Core
PROJECT SUMMARY The Admin Core will execute the administrative needs of SPORE investigators and collaborators and optimize use of the resources and intellectual depth available to...
Core B - Biospecimen/Pathology Core
PROJECT SUMMARY The goal of the NYU Melanoma SPORE Core B (Biospecimen Procurement & Utilization Core) is to stimulate patient-centered melanoma translational research by provi...
Project 2
PROJECT 2 SUMMARY Immune checkpoint inhibitor (ICI) adjuvant therapies—including ipilimumab (IPI; targets cytotoxic T lymphocyte- antigen 4) and nivolumab (NIVO; targets programmed...
Project 3
PROJECT 3 SUMMARY Immune checkpoint inhibitors have transformed melanoma treatment, producing durable responses, prolonged survival, and clinical benefit in a significant proportio...