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20,252 grants found
Showing 16,001 – 16,020 of 20,252 grants
Regulatory T cells and the tumor microenvironment
PROJECT SUMMARY I have been dissecting the mechanisms of immune regulation for ~27-years, and have been discovering and dissecting immune inhibitory mechanisms in cancer for over 1...
Emergency Myelopoiesis in the Pathogenesis of Myeloid Malignancies
PROJECT DESCRIPTION Our overall goals are to understand how emergency myelopoiesis contributes to the pathogenesis of myeloid malignancies, dissect the underlying metabolic and epi...
Novel Mechanisms Controlling SCLC Tumor Initiation
PROJECT SUMMARY / ABSTRACT The goal of this project is to identify novel molecular determinants of small-cell lung carcinoma (SCLC) preneoplastic development.Relatively little is k...
Mechanism of microbiota-mediated potentiation of checkpoint blockade efficacy in lung cancer
The discovery that the host immune system can be harnessed to attack solid tumors and improve overall survival for patients has been transformative.However, only certain tumors are...
Inactivation of MSH3 in Colorectal Cancer and Race
Abstract The occurrence of CRC in the United States shows a large disparity among recognized races and ethnicities, with African Americans demonstrating the highest incidence and m...
Cell-cycle dependent gene transcription through activation of B-Myb
PROJECT SUMMARY The cell cycle is a carefully controlled cellular process that maintains the integrity of organismal growth. Deregulation of the cell cycle leads to cell death or i...
Targeting abnormal immunomechanics in the glioblastoma microenvironment to improve therapeutic response
ABSTRACT Newly diagnosed glioblastoma (GBM) patients have a dismal survival of less than 2-years despite aggressive currently available treatments. Immune checkpoint blockade (ICB)...
Elucidating the Relationship Between Cell Proliferation and Invasion
PROJECT SUMMARY/ABSTRACT Over the last five years, three cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have been approved for the treatment of metastatic breast cancer. CDK4/6i...
Targeting the suppressive immune microenvironment in leptomeningeal melanoma metastases
Melanoma is a highly metastatic tumor, with a propensity to spread to the skin, lungs and brain. In ~5% of cases, patients also develop leptomeningeal melanoma metastases (LMM: e.g...
Humanized anti-CXCL1 antibody for bladder cancer therapeutics
SUMMARY Background: The progressive growth of tumors and their ability to metastasize are dependent on an adequate tumor blood supply. Chemokine (C-X-C motif) ligand 1 (CXCL1), a w...
The Impact of Type II IL4R Signaling on Breast Cancer Brain Metastasis
PROJECT SUMMARY/ABSTRACT Metastasis, the dissemination of cancer from the primary tumor to distant organs, accounts for ~90% of cancer deaths and is a significant source of morbidi...
Utilization of cervical cancer prevention tools and role of high-risk HPV type in the persistent cervical cancer disparities experienced by American Indian/Alaska Native women
PROJECT SUMMARY Dr. Bruegl is an Assistant Professor in the Department of Obstetrics and Gynecology at Oregon Health and Science University and a national Robert Wood Johnson Found...
THE CONTRACTOR SHALL PROVIDE COMPREHENSIVE CLINICAL SITE AND STUDY MONITORING SERVICES FOR THE NCCIH-FUNDED (PRIMARY OR SECONDARY) EXTRAMURAL CLINICAL
CLINICAL STUDIES MONITORING SERVICE (CSMS), NATIONAL CENTER FOR COMPLEMENTARY AND INTEGRATIVE HEALTH.This is a monitoring contract that performs quality assurance on NCCIH-funded e...
Metabolic determinants of metastatic heterogeneity: quantitative experiments and mathematical models
Project Summary/Abstract It is critically important to establish the causes of organ-specific metastasis; without this knowledge, prevention and timely treatment of metastatic canc...
Metabolic determinants of metastatic heterogeneity: quantitative experiments and mathematical models
Project Summary/Abstract It is critically important to establish the causes of organ-specific metastasis; without this knowledge, prevention and timely treatment of metastatic canc...
Metabolic determinants of metastatic heterogeneity: quantitative experiments and mathematical models
Project Summary/Abstract It is critically important to establish the causes of organ-specific metastasis; without this knowledge, prevention and timely treatment of metastatic canc...
Domain-Knowledge Informed Deep Learning for Early Detection of Pancreatic Cancer
PROJECT SUMMARY The goal of this project is to leverage deep-learning algorithms on Electronic Health Records (EHRs) to improve early detection of pancreatic ductal adenocarcinoma...
Domain-Knowledge Informed Deep Learning for Early Detection of Pancreatic Cancer
PROJECT SUMMARY The goal of this project is to leverage deep-learning algorithms on Electronic Health Records (EHRs) to improve early detection of pancreatic ductal adenocarcinoma...
Understanding and targeting the DNA replication stress in cancer cells
Project Summary DNA replication problems collectively known as replication stress are a major sources of genomic instability in cancer cells and also a vulnerability of cancer that...
Understanding and targeting the DNA replication stress in cancer cells
Project Summary DNA replication problems collectively known as replication stress are a major sources of genomic instability in cancer cells and also a vulnerability of cancer that...