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20,252 grants found
Showing 1,581 – 1,600 of 20,252 grants
Cornell FIRST Administration Core
Project Summary (Administrative Core) The Administrative Core for the Cornell FIRST program will support the hiring and retention of 10 new assistant professors from groups underre...
Clonal growth and prediction of monoclonal B-cell lymphocytosis
ABSTRACT Monoclonal B-cell lymphocytosis (MBL) is a precancerous state affecting 8-10 million adults with no existing cancer control strategies. As a precursor to chronic lymphocyt...
Radiotheranostic host:guest pretargeting with Pb-203 and Pb-212
Project Summary For monoclonal antibody(mAb)-based radiopharmaceuticals to widely impact precision nuclear medicine, strategies that both improve the convenience and reduce the rad...
Developing Acute Myeloid Leukemia Models with Diverse Ancestral Origins
Project Summary Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow. There is a well-documented survival disparity with non-Hispanic white (NHW) patients having...
Lysosome Trapped FAP-Targeted Theranostics for Pancreatic Cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a lethal, treatment-refractory malignancy characterized by fibroblast-rich stroma. While external beam radiation therapy (EBRT)...
Targeting the Mitochondria to Overcome Resistance to Immune Checkpoint Inhibition in Malignant Pleural Mesothelioma
PROJECT SUMMARY Malignant pleural mesothelioma (MPM) is a cancer caused by exposure to asbestos. Inhaled asbestos fibers become embedded in the lining of the lungs, causing harmful...
A novel gene-based immunotherapy inducing melanoma destruction
A novel gene-based immunotherapy inducing melanoma destruction In the U.S., nearly 100,000 new melanoma diagnoses and 8,000 deaths are expected in 2023. Despite the advent of immun...
The role of bile acid metabolomics in graft-versus-host disease
Allogeneic hematopoietic cell transplantation (allo-HCT) is a therapy with curative intent for a variety of malignant and non-malignant diseases. One of the major complications aft...
Leveraging the metastatic tumor stroma to limit breast cancer progression
Project Abstract Over 297,790 new cases of invasive breast cancer diagnoses and 43,170 deaths from metastatic breast cancer (mBC) are expected in the USA this year (SEER database)....
An RNA-Dependent Innate Immune Response Pathway to Base-Damaging Chemotherapeutics
PROJECT SUMMARY The objective of this proposal is to define the mechanism and functional role of innate immune signaling events during base damaging cancer chemotherapy. These agen...
Misoprostol to Optimize Prevention of Cancer of the Cervix: A Randomized Trial (MISOPCx Project)
Abstract Cervical cancer is the leading cause of cancer morbidity and mortality among women in low-and-middle-income countries (LMICs) such as in Africa where screening by visual i...
Targeting nutrient microenvironment imprinted therapy resistance in pancreatic cancer
PROJECT SUMMARY/ABSTRACT A major hurdle in the clinical management of pancreatic adenocarcinomas (PDAC) is the profound resistance to chemotherapeutics exhibited by these tumors. P...
Targeting Purinergic Signaling to Block the Effects of Seizures on Glioma Progression
PROJECT SUMMARY There is growing evidence that neuronal activity contributes to glioma proliferation and progression, but the molecular mechanisms by which this occurs are not well...
SRNT 2024 Annual Meeting Global Support
SUMMARY/ABSTRACT The Society for Research on Nicotine & Tobacco (SRNT) is the only scientific association dedicated exclusively to the support of researchers, academics, treatm...
A Novel Regulator of Antitumor Immunity and Immunotherapy
ABSTRACT Tumor antigen-triggered T cell receptor (TCR) signaling in the cytoplasm and transcriptional/epigenetic control in the nucleus are central to CD8+ T cell-dependent antitum...
Programmable biohybrid system for cancer therapy
Project Summary/Abstract Research: Despite the recent groundbreaking discoveries in the field of nanomedicine, tumor-specific delivery of therapeutics still poses a big hurdle for...
Triggering Aberrant RNA Processing for RCC Therapy
ABSTRACT Renal cell carcinoma (RCC) is one of the most lethal urologic malignancies with approximately 81,800 new cases and 15,000 deaths estimated in 2023. Clear cell RCC (ccRCC)...
2024 Annual Conference Grant: American Society of Preventive Oncology
ABSTRACT The mission of the American Society of Preventive Oncology (ASPO) is the exchange and translation of scientific information to reduce the cancer burden and for the continu...
A pro-metastatic secretory program activated by epithelial-to-mesenchymal transition
Project Summary/Abstract Candidate: Dr. Xiao has received broad training in cell and cancer biology, including postdoctoral training at UT- Southwestern Medical Center (UTSW) and ...
Microbiota and Cancer Immunity
ABSTRACT Support is requested for a Keystone Symposia conference entitled Microbiota and Cancer Immunity, organized by Drs. Giorgio Trinchieri, Jenny P.Y. Ting and Hsing-Jien Kung....