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20,252 grants found
Showing 141 – 160 of 20,252 grants
Gynecologic cancer care: Improving clinical trial enrollment through molecular matching with targeted therapies and improving equal access to care and research for all populations
Project Summary/Abstract Gynecologic Cancer remains an underfunded area of research with funding to lethality scores significantly lower than other cancer sites. Endometrial cancer...
An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation
ABSTRACT Cigarette smoking is the leading cause of preventable death and disability in the United States. Smoking cessation rates have stagnated in recent years, underscoring the n...
Effect of the plantar skin microenvironment on tumor metastasis and drug tolerance
Project Summary Patients with advanced acral melanoma (AM) suffer worse outcomes relative to patients with cutaneous melanoma (CM), in part, because they do not respond as well to...
Core A: Administration, Communication and Project Management
CORE A: SUMMARY/ABSTRACT This Program Project comprises four individual projects, which will: extend the WISDOM Study to evaluate the use of subtype-specific risk models and associ...
Project 4: CISNET Modeling of outcomes and cost for risk-based screening strategies
Project 4 will evaluate the benefits, harms, and costs of personalized screening using one of the CISNET models of breast cancer. We will evaluate the current approaches to persona...
Core B: Biostatistics and Bioinformatics
CORE B: SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core’s primary goal is to collaborate with the P01 Investigators and other Core resource scientists to ensure that res...
Core C : Population Genomic Risk Assessment
CORE C: SUMMARY/ABSTRACT A polygenic risk score (PRS) combines risk information from many common genetic variants associated with a disease to predict the risk of that disease. PRS...
Project 1: Implementing Risk-based Tools that Incorporate Tumor Biology to Optimize Screening and Prevention
In 2016, we initiated the first large-scale clinical trial to personalize screening based on individual risk, which varies significantly among women. The WISDOM Study is a multi-ce...
Core D: Patient Centered Outcomes and Risk Communication
CORE D: SUMMARY/ABSTRACT The ability to effect change in healthcare is as dependent on a successful implementation as it is on the intervention itself.Personalization of screening...
Epidemiology of the gut-liver axis and hepatocellular carcinoma risk in a multiethnic liver cirrhosis cohort: defining the role of bacteria, metabolites, and glycoproteins
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults in which most cases develop in patients with liver cirrhosis. The incidence and mor...
Project 2: Optimizing polygenic risk scores to inform breast cancer screening and prevention
PROJECT 2: Summary/Abstract The ongoing WISDOM Study of risk-based versus annual breast cancer screening is one of the first-ever applications of population-wide genetic testing to...
Project 3: Integration of mammographic AI, clinical, and genomics information to improve breast cancer subtype-specific risk-based screening and prevention
PROJECT 3: Summary The ongoing WISDOM risk-based breast cancer screening and prevention trial, which started in 2016, is a ground-breaking comparative effectiveness study to establ...
TOPIC NUMBER: 464 SBIR PHASE I - UNIFIED DATA COMMONS SOLUTION FOR PUBLIC DOMAIN,IN-HOUSE AND THIRD-PARTY MULTIMODAL CLINICAL DATA.
This proposal sets out to deliver a solution, EICON MULTIMODAL, that has three main objectives.Firstly, to facilitate access to multimodal clinical data in the public domain by pro...
FY24 SBIR PHASE I TOPIC NO. 459 PROJECT TITLE: AN AUTOMATED SCREENING PLATFORM FOR EARLY IDENTIFICATION OF MALNUTRITION IN CANCER PATIENTS
This project aims to develop an automated screening platform for early identification of malnutrition in cancer patients by creating a machine-learning-based model that combines CT...
TOPIC NUMBER: 458 SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE IONCOBIOMIX: MICROBIOME-BASED TEST FOR PROSTATE CANCER RISK
Prostate cancer (PCa) remains a significant global health challenge, particularly in the United States where it is the most common non-cutaneous cancer among men. The landscape of...
Phase Changing Ultrasound Contrast Agents for Deep Tissue Imaging of Cellular Immunotherapies
PROJECT SUMMARY Adoptive cellular immunotherapies are an established therapeutic weapon in the fight against cancer. However, there is a large variability in anti-tumor responses a...
Targeting EBV-associated lymphomas
ABSTRACT Epstein-Barr Virus (EBV) is the etiological agent of several hematopoietic malignancies including multiple types of non-Hodgkin lymphoma (NHL). These EBV-positive NHL subt...
Optimizing non-invasive focused ultrasound for brain tumor liquid biopsy in a rat glioma model - Phase I
SUMMARY The NeuroAccess system represents a pioneering approach to address the unmet critical need for effective blood-based molecular characterization in brain cancer patients. By...
Built environment approaches to physical activity: Testing community-driven implementation strategies
PROJECT SUMMARY/ABSTRACT Built environment approaches make it safer and easier for people across the life span to walk, bicycle, or wheelchair roll, and mitigate barriers to physic...
Tissue engineered organ-specific cancer metastasis model for cancer research
Understanding the biology of cancer metastases is critical to improving the treatment of cancer. A key challenge in these efforts has been the lack of cancer models that can recapi...