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20,252 grants found
Showing 1,561 – 1,580 of 20,252 grants
NEUROD1 function in SCLC fate and plasticity
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung tumor responsible for > 30,000 deaths annually in the US. SCLC has a two-year survival rate of ~6% with...
Development of Novel Antibody Conjugates for Cancer Immunotherapy
Abstract Targeted protein degradation by chimeric molecules has emerged as a novel therapeutic modality. The bifunctional chimeric molecules usually have one end binding to the pro...
Optimizing anti-wild-type IDH1 therapy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most deadly of the common cancers, with limited treatment options. Chemotherapy is marginally effective, while targeted or immunologi...
Modulation of ITK signaling for sustainable adoptive T cell therapy
Project Summary/Abstract CAR-T cell therapy has demonstrated success in curing B cell (CD19+) malignancies and has shown promise in treating lupus. However, the cytotoxic and short...
AYA ACCESS Study: An enhanced eHealth and Chat-bot enabled delivery model for clinical genetic services in community AYA cancer patients
Each year, approximately 90,000 adolescents and young adults (AYA; National Cancer Institute defined age 15- 39-years at cancer diagnosis) are diagnosed with cancer. Despite increa...
2024 Annual Meeting of the American Society for Investigative Pathology
The 2024 Annual Meeting of the American Society for Investigative Pathology (ASIP) will be held April 20-23 at Renaissance Baltimore Harborplace Hotel in Baltimore, MD. The Annual...
Cell Signaling in Cancer- From Mechanisms to Therapy
PROJECT SUMMARY ABSTRACT Decades of research has revealed the complexity of cellular signaling networks involved in control of cellular processes and their exceptional vulnerabilit...
ANCHOR Correlative Science Administrative Supplement
7. Project Summary / Abstract The ANCHOR Study is an ongoing, longitudinal, multicenter trial in people living with HIV (PLWH), which demonstrated that treating anal high-grade squ...
Research Supplement to Promote Diversity in Health-Related Research
A defining property of cancers that lack intrinsic immune surveillance is the absence of costimulatory context in myeloid cells—macrophages and dendritic cells (DC)—preventing tumo...
Glial immune signaling in radiation-induced brain injury
ABSTRACT (parent award, R01 CA251110), unchnaged Cranial radiation therapy (CRT) for the treatment of CNS cancers often leads to unintended and debilitating cognitive impairments....
Targeting Microenvironmental Signals in Myeloid Malignancies
ABSTRACT Interactions of stem cells with their surrounding microenvironment are known to be essential for both normal development, and for sustaining self-renewing adult stem cells...
Supportive Care Needs in Asian Americans with Metastatic Cancer
PROJECT SUMMARY/ABSTRACT Cancer is the leading cause of death for Asian Americans, the fastest growing U.S. immigrant group projected to outnumber Latinx Americans by 2065. Provisi...
MYCN drives a ferroptotic vulnerability in neuroblastoma
Summary: Apoptosis is a type of programmed cell death and has for a long time been appreciated to be a hallmark of cancer cells. In recent years, drugs targeting the apoptotic path...
Administrative Supplement to Existing NIH Grant-Purchase of a Equipment
Project Summary/Abstract Malignant brain tumors are aggressive cancers that have high proliferative rates with much higher energy requirements and high mortality rates. Despite int...
Mechanistic studies of hirsutinolides and azetidine based small molecule inhibitors of STAT3
Project Summary/Abstract Triple-negative breast cancer (TNBC) is generally treated with chemotherapy, which only achieves incomplete response. Relapsed disease has no new treatment...
Exploring m6A RNA Modification in HIV-associated Cancers in Aging Populations (HIV-Associated Cancers in Aging Populations)
Abstract People living with HIV (PWH) have an increased incidence of cancers and worse outcomes than those not infected with HIV. People at the age of 50 or older also have increas...
Maximizing Selective Inhibition of Clinically Observed MET Mutants
PROJECT SUMMARY On-target resistance to small-molecule inhibitor therapy is a major challenge in cancer treatment. While the design of novel compounds remains an important long-ter...
Elucidation of the Mechanism of Microhomology-Mediated End Joining by DNA Polymerase Theta
PROJECT SUMMARY Double-stranded DNA breaks (DSBs) are a severe form of DNA damage that can give rise to devastating chromosomal aberrations. While DSBs are usually repaired with hi...
Investigating lipid phenotype as a metabolic adaptation to microenvironmental stress
Breast cancers emerge through a years-long process of somatic evolution within the physical constraint of milk ducts, characterized by accumulation of heritable genetic and epigene...
Cornell FIRST
Cornell University aims to increase the number of minoritized faculty in the biological, biomedical, and health sciences through establishing an NIH FIRST Program at Cornell Univer...