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20,252 grants found
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Strategies for Reaching and Impacting Our Communities Sustainably (NWP-ROCS Program)
Project Summary Widespread implementation, scale-up, and sustainability of culturally-appropriate, evidence-based programs is critical to reducing the significant and disproportion...
Mechanisms of Chromosome Shattering from Defective DNA Replication
PROJECT SUMMARY/ABSTRACT Mis-segregated chromosomes entrapped in micronuclei are susceptible to catastrophic shattering through a process termed chromothripsis. The resulting DNA f...
HER2 PET imaging to assess HER2 heterogeneity and predict response to HER2-targeted ADC therapy in urothelial carcinoma
PROJECT ABSTRACT The management of metastatic bladder/upper tract (urothelial) cancer has been transformed over the past five years, with FDA approval of anti-PD-1/PD-L1 antibodies...
Dissecting mechanisms of sensitivity to B7-H3 (CD276)-targeted therapeutics in prostate cancer (PC)
PROJECT SUMMARY/ABSTRACT Background. Agents that inhibit Androgen Receptor (AR) signaling are the standard-of-care treatment for prostate cancer (PC) patients. Unfortunately, essen...
Structural and dynamic basis for PRKACA-dependent signalopathies
The PRKACA gene encodes for the catalytic subunit of protein kinase A (PKA-C). Recent ge- nomic efforts have identified several single-site mutations, insertions, and aberrant fusi...
Monitoring response of neoadjuvant therapy in primary bladder cancer using hyperpolarized 13C MRI
PROJECT SUMMARY / ABSTRACT The goal of this proposal titled “Monitoring response of neoadjuvant therapy in primary bladder cancer using hyperpolarized 13C MRI” is to develop a meta...
The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk
Summary Over the past twenty years, the use of prescription opioids among the American population has reached alarming levels, with over 17% of Americans using prescription opioids...
Immunological consequences of LINE-1 expression in cancer
Project Summary Approximately 200,000 new cases of ovarian cancer (OC) occur per year, but overall survival has not significantly changed for decades and novel therapies are urgent...
MedSupport: A Novel Multilevel Intervention to Identify and Address Barriers to Pediatric Medication
Pediatric nonadherence to medication is a significant public health problem, and rigorous research repeatedly documents that nonadherence increases risk for hospitalization, health...
Assessing Metabolically Reprogrammed and Purified CD19-CAR-T in NHL and CLL
ABSTRACT Adoptive T cell therapy (ACT) is a promising approach for treating patients with advanced malignancies. Advances in molecular biology and genetic engineering have led to t...
Clinical Implications of Natural Killer-derived exosomal miRNAs in Neuroblastoma
PROBLEM. Pediatric tumors represent a very heavy social and economic burden with profound emotional involvement not only for the directly affected children but also for their famil...
Elucidating the role of transcriptomics in driving ethnicity and ancestry-related disparities in colorectal cancer
ABSTRACT The benefits of precision oncology advances in colorectal cancer (CRC) have not been shared by all individuals. Prognosis among minority groups remains stubbornly low in c...
ImmunoPET Evaluation of Focused Ultrasound-mediated Delivery and Immunomodulation by anti-CD47 Immunotherapy in the Setting of Current Standard-of-Care Treatment for Glioblastoma
Project Summary: A long-standing problem in the treatment of glioblastoma (GBM), the most common and deadly primary braintumor, is the efficient delivery of therapeutics to the hig...
Cellular basis for cancer treatment related GDF15 expression and the regulation of skeletal muscle fibrosis and neuromuscular integrity.
ABSTRACT One of the great achievements in medical sciences is the improved survival rate among children diagnosed with cancer. Although estimates indicate the 5-year survival rate...
Impact of Clonal Hematopoiesis of Indeterminate Potential (CHIP) on tumor microenvironment and clinical outcomes in triple negative breast cancer
PROJECT SUMMARY With age and exposure to genotoxic stress, tissues throughout the body acquire somatic mutations. In the blood and bone marrow, somatic mutations are frequently fou...
Metabolic control of tRNA-mediated translational reprogramming in glioblastoma
ABSTRACT Glioblastoma (GBM) ranks among the most lethal of human cancers. Standard-of-care therapies offer only palliation and molecularly targeted treatments have shown little ben...
Chemoproteomic discovery and characterization of covalent ligands for the oncoprotein CIP2A, a unique vulnerability in BRCA1/2-deficient cancers
Loss-of-function BRCA1/2 mutations lead to defective homologous recombination (HR) activity, a frontline DNA damage repair pathway that accurately addresses double-strand breaks. I...
SOX9 as a key transcriptional regulator of SPEM cells in gastric carcinogenesis
PROJECT SUMMARY Gastric cancer is currently the fourth leading cause of cancer deaths worldwide and is diagnosed in approximately one million people per year. The most common type...
Define the molecular mechanisms in and identify biomarkers for FAK-driven hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is a deadly cancer with poor prognosis and limited therapeutic options. Biopsies are contraindicated in HCC, restricting our ability to iden...
Using artificial intelligence to discover spatial, genomic, and pathologic biomarkers to guide and augment immune checkpoint inhibitor therapy for gastric cancer
PROJECT SUMMARY/ABSTRACT Outcomes for patients with gastric cancer, which is the fourth-most lethal cancer worldwide, are poor and improved therapies are needed. While immune check...