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20,252 grants found
Showing 1,521 – 1,540 of 20,252 grants
Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation
Project Summary/Abstract The overarching goal of the proposed research is to elucidate the initiating mechanisms in the development of cancer-prone chronic inflammation for cancer...
Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCC
Project Summary/Abstract Head and neck squamous cell carcinoma (HNSCC) are often associated with human papillomavirus (HPV) infection. The incidence of HPV+ HNSCC has been rapidly...
Activation of Drug and Biologic Conjugates by Click Chemistry and their Tumor-selective Targeting for Prostate Cancer Suppression
A critical unmet need in prostate cancer management is to prevent disease advance to a castration-resistant and chemotherapy-inert lethal stage. We will explore a novel anti-cancer...
Overcoming therapy resistance in melanoma
PROJECT SUMMARY AND ABSTRACT Rationale: Despite novel chemotherapies have significantly improved the prognosis of melanoma patients, drug resistance occurs inevitably and tumor pro...
Adipose Tissue Reprograms Acute Lymphoblastic Leukemia Cells to Facilitate CNS and Bone Invasion
PROJECT SUMMARY Obesity is associated with an increased risk of relapse from acute lymphoblastic leukemia (ALL), the most common childhood cancer. We have uncovered a novel mechani...
CUIMC Calabresi Clinical Oncology Career Development Program
PROJECT SUMMARY/ABSTRACT This application seeks to establish the Paul Calabresi Career Development Award for Clinical Oncology (K12) at the Columbia University Irving Medical Cente...
Randomized Trial to Improve Care of Patients with Hereditary Cancer Syndromes
PROJECT SUMMARY Among the estimated one million Americans who have screened positive for specific genetic variants related to Hereditary Breast and Ovarian Cancer Syndrome (HBOC) o...
The role of SERPINB3 in cervical cancer therapeutic resistance
PROJECT SUMMARY High SERPINB3 is a biomarker of radioresistance, and a potential therapeutic target for cervical cancer. Our recent work demonstrated that CRISPR-Cas9 knock out of...
Disruption of the circadian clock in lung cancer
Project Summary Disruption of the molecular circadian clock is indicative of poor prognosis in non-small cell lung cancers (NSCLCs), but direct evidence for a causal link between c...
The Immunomodulatory Function of Cyclin E1 in Ovarian Cancer and Therapeutic Targeting
A. Project Summary/Abstract Ovarian cancer is the second most common cause of gynecologic cancer death in women around the world. High-grade serous ovarian cancer (HGSOC) accounts...
Reversing cancer immunosuppression using attenuated Listeria monocytogenes
PROJECT SUMMARY The past decade has witnessed a breakthrough in cancer immunotherapy, from checkpoint inhibitors to adoptive T cell therapies, a new pillar in our armament of anti-...
Bioengineering adipocytes for cancer therapy
PROJECT SUMMARY Increased glucose and fat metabolism are essential for tumor progression. Recent work showed that cold- induced activation of brown adipose tissue (BAT), a unique a...
Mechanisms of Hyperprogression to Immunotherapy in SMARCB1-Deficient Renal Malignancies
PROJECT SUMMARY The loss of the tumor suppressor gene SMARCB1, a core member of the SWItch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, defines a group of malign...
Modulation of ferroptotic cell death by mitochondrial calcium signaling
Project Summary/Abstract Ferroptosis is a unique type of programmed cell death that is induced by excessive lipid peroxidation. Emerging evidence suggests that ferroptosis represen...
Bromodomain and extra-terminal motif (BET) inhibitors in Solitary fibrous tumor (SFT)
Project Summary Solitary fibrous tumor (SFT), historically also called hemangiopericytoma (HPC), is a soft-tissue sarcoma occurring in adults and infants. This nonhereditary cancer...
Characterization of HER2 inhibitors with a novel mechanism of action
ABSTRACT About 1 in 8 women in the U.S. will develop invasive breast cancer during their lifetime. Human Epidermal growth factor Receptor-2 (HER2) is a clinically validated target...
Developing a communication support intervention for cancer caregivers in emerging and young adulthood
Project Summary Caregivers in emerging and young adulthood account for nearly half of all caregivers in the United States; however, they are significantly underrepresented in cance...
Epigenetic regulators define a dynamic chromatin landscape in NUP98-rearranged leukemia
Project Summary Chromosomal translocations producing oncogenic fusion proteins are common drivers of many types of cancer, including leukemia. Translocations involving the Nucleopo...
Targeting Perp in PDAC tumor and cancer cachexia
PROJECT SUMMARY/ABSTRACT Pancreatic cancer is one of the deadliest cancers in the US, at a 5-year survival rate of ~11%. One of the hallmarks of this cancer are the driver mutation...
Targeting Glycogen Metabolism in Ewing's Sarcoma: Diagnostic, Prognostic, and Therapeutic Applications
Abstract: Ewing’s Sarcoma (ES) is the second most common pediatric bone cancer. Intensified chemotherapy regimens have only incrementally improved recurrent or metastatic ES outcom...