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20,252 grants found
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CSHL 2024 Conference on the PARP Family & ADP-Ribosylation
Cold Spring Harbor Laboratory Conference on The PARP Family and ADP-ribosylation April 3 – 6, 2024 ABSTRACT This proposal seeks support for a meeting on “The PARP Family and ADP-ri...
A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state
IMAT R61 Abstract In addition to its well-recognized roles in neuronal computation and cardiac contractions, the voltage across the plasma membrane has been implicated as a fundame...
Clinical Translation of Interstitial Chemophototherapy with Light-Activated Nanoparticulate Doxorubicin
Summary POP BIO’s goal is to commercialize interstitial chemo-phototherapy (I-CPT) as a new therapeutic option for locally advanced liver cancers. Doxorubicin (Dox) can be actively...
CRISPR and Humanized mice-based Discovery of a Novel Drug target for HCC Therapy
PROJECT SUMMARY Hepatocellular carcinoma (HCC), the most common type of liver cancer, accounts for over 30,000 deaths each year in the United States alone. Regrettably, current the...
Investigating Interactions Between Radiation and Antibody-Drug Conjugates in Bladder Cancer
PROJECT SUMMARY Bladder cancer is responsible for 80,000 cancer diagnoses and 20,000 deaths annually in the US. Approximately one-fourth of bladder cancer patients will be diagnose...
Refinement of a Training Module to Improve Discussions of Sexual Orientation and Gender Identity in Cancer Clinics
PROJECT SUMMARY/ABSTRACT Sexual and gender minority (SGM) individuals comprise a growing population of over 20 million people in the United States. SGM individuals experience cance...
Synthetic combination therapy for diffuse midline gliomas
PROJECT SUMMARY Diffuse midline gliomas (DMGs) are lethal brain tumors in children. Patient prognosis is very bleak with median overall survival of ~9 months. These tumors typicall...
Molecular mechanisms and therapeutic principles of VISTA+ triple-negative breast cancers
Project Summary/Abstract Triple-negative breast cancer (TNBC) is highly aggressive and uniformly lethal in the metastatic setting despite recent approvals of immuno-therapeutics fo...
Develop novel bispecific antibody-drug conjugates against metastatic lethal prostate cancer across subtype
Abstract Antibody-drug conjugates (ADCs) have shown promise as targeted therapeutics for treating cancer, including solid tumors. However, no ADC has gained FDA approval for treatm...
Caregiver Education with Interactive Neurodevelopmental Games to Improve Cognitive and Social-Emotional Outcomes in Infants Undergoing Treatment for Medulloblastoma
PROJECT SUMMARY/ABSTRACT Childhood brain tumor survivors are at significant risk for cognitive and social-emotional difficulties, which are associated with reduced quality of life....
Developing inhibitor combinations through identification of drug tolerant cell populations
PROJECT SUMMARY/ABSTRACT Drug tolerant cells limit clinical success of many types of anticancer therapies. Drug tolerance has largely been associated with cell heterogeneity. Surpr...
Engineered T cells for improved migration into solid tumor sites
Adoptive transfer T cell-based immunotherapies and checkpoint inhibitor immunotherapy have shown significant promise in the treatment of cancers. However, checkpoint inhibitor ther...
PSMA ligand radiosensitizers to improve the therapeutic index of external beam radiotherapy for prostate cancer
PROJECT SUMMARY/ABSTRACT: Radiation therapy has a definitive role in curing high risk, very high risk, and even oligometastatic or low- volume metastatic disease as phase III trial...
Uncoupling Ral signal transduction from Exocyst functions
Ras is the most mutated oncoprotein. FDA-approved inhibitors target a small subset of Ras mutants and two of the three oncogenic Ras signaling effectors, Raf>MEK>ERK and PI3K...
The role of UbcH7 in male breast cancer
Abstract While breast cancer is one of the most common cancers in women in the U.S., it is extremely rare in men, accounting for less than 1% of all breast cancer cases. Although t...
Anti-cancer effects of tocotrienols and a carboxychromanol in an innovative colon cancer model
Colorectal cancer (CRC) is one of the leading causes of cancer death, but there is no effective treatment for the late-stage cancer. Early detection with colonoscopy appeared to lo...
Investigating hypoxia as a determinant of malignant fates in pancreas cancer
Only one in ten pancreatic cancer patients is alive 5-years after their diagnosis. Unfortunately, this outlook has not improved significantly in decades. This is in stark contrast...
Targeting BRCA1/2-deficient cancers with folate and vitamin C
Project Summary BRCA1 and BRCA2 are tumor suppressor genes frequently inactivated in cancer, particularly in ovarian and breast cancers. Despite recent advances in therapy, many pa...
Impact of tamoxifen treatment on neutrophils in breast cancer patients
Project Summary Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) approved by FDA for treatment of estrogen receptor positive (ER+) early stage and advanced breast...
Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
PROJECT SUMMARY Nearly 70% of the ~ 30 million adult cigarette smokers in the US want to quit, and 55% report trying to quit at least once in the past year - yet, over 90% fail des...