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20,252 grants found
Showing 1,461 – 1,480 of 20,252 grants
Development of bifunctional CDK2 inhibitors for treatment of CCNE1-driven cancers
PROJECT SUMMARY Ovarian cancer is among the five leading causes of cancer death in the US with estimated 20,000 new cases and more than 13,000 deaths in 2023. High-grade serous ova...
Using DNA Methylation Markers for Diagnosis and Prognosis of Upper Tract Urothelial Carcinoma
SUMMARY Upper Tract Urothelial Carcinoma (UTUC) is a rare disease that accounts for 5-10% of all urothelial tumors with an estimated annual incidence in Western countries of almost...
DCE-MRI guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer
PROJECT SUMMARY / ABSTRACT Choosing the more effective therapy is imperative for borderline-resectable pancreatic cancer (BRPC). BRPC is a subcategory of pancreatic adenocarcinoma...
Developing New Treatment Strategies for Neuroendocrine Prostate Cancer
Project Summary/Abstract Neuroendocrine prostate cancer (NEPC) is the most virulent form of the disease. Loss of the tumor suppressors TP53/RB1 is ubiquitous in NEPC, but molecular...
Integrative Targeted Therapy for Melanoma
PROJECT SUMMARY/ABSTRACT Despite breaking advances in melanoma treatment such as adoptive cell transfer and immune checkpoint blockade, the clinical outcomes remain unsatisfactory...
GPC2 CARs in neuroblastoma: Mechanisms of resistance and efficacy of next-generation constructs
PROJECT SUMMARY Children with high-risk neuroblastoma (NB) have a significant risk of treatment failure and death emphasizing the need to develop novel targeted therapies, which co...
Interplay of natural killer cells and extracellular matrix proteins in solid cancers
Project Summary/Abstract: Natural killer (NK) cells have long been known to provide critical early defense against viral infections and malignancies. Nevertheless, most of the clin...
Role of the CTLH E3 ubiquitin ligase in breast cancer progression
Project Summary / Abstract HER2-positive breast cancers are highly aggressive and associated with poor prognosis. HER2-targeted therapy is the preferred treatment for these cancers...
Uncovering the heterogenous role of senescence in prostate immune suppression and tumorigenesis
PROJECT SUMMARY Prostate cancer is the second-leading cause of cancer-related death in American men. While most prostate cancers are hormone sensitive and respond well to hormone t...
Role of CXCR3-CXCL10 signaling in T-ALL CNS disease
Extramedullary infiltration of leukemic cells to the meninges (CNS disease/relapse) is a poor prognostic factor for patients with T-cell acute lymphoblastic leukemia (T-ALL). To da...
Mechanistic studies of hirsutinolides and azetidine-based small molecule inhibitors of STAT3
PROJECT SUMMARY/ABSTRACT Triple-negative breast cancer (TNBC) is generally treated with chemotherapy, which only achieves incomplete response. Relapsed disease has no new treatment...
Circadian Rhythms in Blood Brain Barrier Permeability and Increased Efficacy of Chemotherapy for Brain Metastases
Project Summary Breast cancer is a devastating disease that affects large numbers of women annually; it is estimated that 1 in 8 women in the United States will be diagnosed with t...
Function of IL35+ B cells in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is notoriously resistant to therapy and has a dismal 5-year survival rate. Development of PDAC is accompanied by changes in stromal response...
Characterizing the role of MARCH5 in apoptosis regulation in acute myeloid leukemia
Project Summary Acute myeloid leukemia (AML) remains a devastating illness, with a clear need for the development of novel anti-leukemic therapy. Inhibition of anti-apoptotic BCL2...
The role of ANGEL2 in TP53-dependent tumor suppression
Project Summary ANGEL2 is an RNA-binding protein (RBP), and member of the catabolite repression 4 (CCR4) family of proteins, which are involved in the modulation of mRNA stability...
ISIC-REPO; ISIC Skin Imaging Repository Enhancements for Promoting Interoperability and Utilization
SUMMARY The International Skin Imaging Collaboration (ISIC)'s overarching goal is to leverage technology to reduce skin cancer mortality and morbidity. The ISIC Archive, creat...
Mechanism and therapeutic targeting of castration resistance in SPOP-mutated prostate cancer
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed malignancy and effective treatment of castration- resistant PCa (CRPC) remains the major challenge in clinic. S...
Genomic bases for African geo-ethnic prostate cancer health disparity
Genomic bases for African geo-ethnic prostate cancer health disparity PROJECT SUMMARY/ABSTRACT With no known cause or modifiable risk factor, prostate cancer (PCa) is characterized...
Targeting LSD1 to prevent therapy-induced transdifferentiation in BRAF mutant colorectal cancer
PROJECT SUMMARY/ABSTRACT BRAF activating mutations occur in approximately 10% of metastatic colorectal cancers (CRCs) and are associated with worse prognosis due to an inferior res...
Circulating biomarkers of clinical response to combination targeted therapies in neuroblastoma
PROJECT SUMMARY/ABSTRACT Children with advanced neuroblastoma (NBL) have poor outcomes despite aggressive, multimodal therapy and new therapeutic approaches are needed. Recent stud...