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20,252 grants found
Showing 1,441 – 1,460 of 20,252 grants
Enabling translation of cancer cell proliferation PET imaging via droplet radiochemistry technology
PROJECT SUMMARY Despite the widespread use and success of [18F]FDG-PET imaging in oncology, there are many situations where [18F]FDG cannot be used for diagnosis or treatment monit...
ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate Cancer
Prostate cancer (PCa) shows a striking degree of clinical variability, with most aging men harboring indolent, low risk PCa that will not threaten their health during their natural...
Exploiting oxidative stress response in uveal melanoma liver metastases
ABSTRACT: Uveal melanoma (UM) is the most aggressive form of intraocular cancer in adults. Primary disease can be effectively treated however, ~50% of patients will develop metasta...
Genetic Mechanisms Controlling Kidney Cancer Immune Escape
Abstract: The CD8 T-cell response to cancer is critical for disease control and response to checkpoint inhibitors. A prevailing feature of all human cancer is the extreme variabili...
Early prediction of lethal phenotypes in triple negative breast cancer using multiscale, multi-modality platforms
Project Summary/abstract Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and poses a clinical challenge due to the lack of tools to predict patien...
Evaluation of the Implementation and Effectiveness of the American College of Surgeons Operative Standards Program
Project Summary For most solid tumors, high-quality surgery represents the greatest potential for cure. While many cancer quality improvement efforts have focused on screening and...
RNA methylation as a novel effector of SETD2 in kidney cancer
ABSTRACT Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers and is the 8th leading cause of cancer death in the United States. In addition to near ubiquito...
UNM FIRST: Administrative Core
PROJECT SUMMARY – ADMINISTRATIVE CORE The University of New Mexico (UNM) is the flagship and largest university in New Mexico, which is one of four majority-minority states. It is...
Regional differences in guideline-concordant cancer care and outcomes among American Indian Alaska Native people
ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-032. American Indian and Alaska Native (AIAN) people expe...
UNM FIRST: Promoting Inclusive Excellence in Neuroscience and Data Science - Administrative Supplement to support FIRST Faculty Travel
ABSTRACT The NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) initiative aims to transform institutional culture by developing communities of biomedical...
Chimeric antigen receptor-modified iNKT cell therapy for CD7+ malignancies
PROJECT SUMMARY/ABSTRACT The major hurdle in developing chimeric antigen receptor (CAR)-T therapy for T-cell malignancies is CAR-T cell fratricide by self-killing, which leads to i...
Effect of SIRPalpha mismatch on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA matched related donor
PROJECT SUMMARY/ABSTRACT Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for patients with hematologic malignancies. It is believed...
Dietary fructose and NASH/HCC progression
PROJECT SUMMARY “Dietary fructose and NASH/HCC progression” Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is emerging as a leading risk factor drivin...
Quality assurance for safe use of AI systems in radiotherapy
Project Summary Artificial intelligence (AI) systems are increasingly used in radiation oncology for tasks such as image reconstruction and registration, autosegmentation, syntheti...
Analysis of a missense SNP in the aryl hydrocarbon receptor repressor gene that may disproportionately increase lung cancer risk in Black Americans
This is a project to study to a single nucleotide polymorphism (SNP) in the aryl hydrocarbon receptor repressor (AHRR) gene that may influence the lung cancer risk of Black/African...
Using Qualitative Methods to Capture Experiences of Breast Cancer Patients and Characterize Knowledge Types and Levels: The First Step in Informing Patient Knowledge Sharing
PROJECT SUMMARY Gaps and misconceptions in patient knowledge can contribute to poor care adherence, decreased quality of life, and even negative outcomes, especially in underserved...
Genetic architecture of thyroid cancer and its clinical utility
PROJECT SUMMARY Thyroid cancer incidence is high, with 44,280 new cases diagnosed in the US in 2021. Thyroid nodule incidence is rising primarily due to increased detection, necess...
Cheminformatics-based identification of leukemia-targeting molecules
SUMMARY Acute myeloid leukemia (AML) is the most common acute leukemia in the US, with ~20,000 new diagnoses and ~11,000 deaths per year. This pernicious hematological malignancy h...
Novel paper-based diagnostics for the rapid detection and monitoring of leptomeningeal disease
PROJECT SUMMARY Leptomeningeal disease (LMD) is the metastasis of cancer cells into the pia arachnoid and cerebrospinal fluid (CSF), and is a devastating disease with survival rate...
The Effect of Time-Restricted Eating on the Efficiency of Chemo- and Hormonal-Therapy in Breast Cancer
There is abundant evidence that obesity confers increased risk for various forms of cancer. The incidence of breast, colon, and liver cancer are all increased in obese populations,...