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20,252 grants found
Showing 1,421 – 1,440 of 20,252 grants
Countering microtubule stabilization within hair follicles in ovarian cancer chemotherapy
Specific Aims (Revised 1-29-2024)For treating ovarian cancer, paclitaxel is the front-line drug used in combination with cisplatin/carboplatin, and is also used alone in a dose den...
Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity
Cancer immunotherapy using checkpoint blockade (CPB) has revolutionized cancer treatment, providing durable cures with acceptable toxicity in some cancer patients. However, only a...
Functional roles of mTOR in tumor persistence
PROJECT SUMMARY The mTOR pathway is a master regulator of nutrient metabolism and cell proliferation in response to environmental cues. It has long been viewed as an important driv...
Functional state of CD8+ T cell immunity in adult T-cell leukemia/lymphoma
Title: Functional state of CD8+ T cell immunity in adult T-cell leukemia/lymphoma Abstract Adult T-cell leukemia/lymphoma (ATLL) is a fatal disease of malignant CD4+ T cells that d...
Targeting mitochondrial vulnerabilities to drive intrinsic melanoma immunogenicity
Project Summary: Immunotherapies have revolutionized the clinical treatment of melanoma; however, these treatment strategies have been ineffective in treating late stage and metast...
Chi gung: a community-based strategy in Chinese immigrant women to improve colorectal and breast cancer screening.
PROJECT SUMMARY/ABSTRACT Research: Cancer screening disparities in Chinese immigrant women (CIW) is an understudied area of health equity. CIW are underserved and face several syst...
Investigating IGF2BP1 as a novel Therapeutic Target for Ewing Sarcoma
Project Summary Ewing sarcoma (ES) is the second most prevalent bone cancer among children. Aggressive in nature, ES is driven by a fusion transcription factor of which EWS/FLI1 ac...
Role of the chromatin regulator HMGA1 in KMT2A-rearranged leukemia
PROJECT SUMMARY/ABSTRACT The objective of this project is to elucidate mechanisms underlying HMGA1 proteins in leukemogenesis and therapy resistance in KMT2A-rearranged (KMT2A-r) a...
Skin Lesion Archive and Annotation for Fusion and Earlier Skin Cancer Detection
Invasive malignant melanoma has risen in incidence for decades. Dermoscopy aids in detection of the earliest and most curable stage of melanoma. The long lead times required for ap...
Communicating for Health Equity in Digital Environments
ABSTRACT Smoking is increasingly concentrated in socioeconomically disadvantaged populations that might not have been reached by the policies and communication campaigns to the sam...
Assessing molecular predictors of triple negative breast cancer therapeutic response in Black, White, and Hispanic patients in a community healthcare system
PROJECT SUMMARY Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that accounts for ~20% of breast cancer diagnoses. Importantly, non-Hispanic-Black (NHB)...
Photothermal Nanoparticles Immune Engineer Tumor-specific T cells for Adoptive Cell Therapy
PROJECT SUMMARY This goal of this proposal is to investigate a novel photothermal nanoparticle-based approach for generating tumor-specific T cells as an adoptive T cell therapy (A...
Quantitative background parenchymal enhancement, measured on contrast-enhanced mammogram, as a novel marker of breast cancer risk
Routine mammographic screening for breast cancer reduces breast cancer mortality. On a mammogram, radiologists assess mammographic density (MD), or the amount of fibroglandular tis...
Discovering and Characterizing Druggable Cysteines in Cancer Dependency Proteins
Project Summary/Abstract The field of cancer research and treatment has greatly advanced due to breakthroughs in DNA sequencing techniques. These developments have accelerated the...
RNA m6A modifications and treatment response in multiple myeloma
PROJECT SUMMARY Multiple myeloma (MM), the 2nd most common hematologic malignancy, remains incurable with high rates of relapse and drug resistance despite recent advances in treat...
Metabolic regulation of immunosuppressive myeloid cells in the tumor microenvironment of pancreatic cancer.
Project Summary Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest human malignancies, with the 5-year survival rate currently at 12%. Little progress towards its treat...
Pediatric Oncology Career Development Program at St. Jude
ABSTRACT St. Jude Children’s Research Hospital (SJCRH) is home to the only NCI-designated Comprehensive Cancer Center dedicated solely to pediatrics, giving our institution a uniqu...
How RNA binding proteins control effector T cell responses
T cell responses rely on the T cell receptor (TCR) for antigen specificity, CD28 for a second signal, and a cadre of additional signals including cytokines and certain TNF superfam...
Adipocyte PD-L1 in the Breast Tumor Microenvironment
ABSTRACT Programmed death-ligand 1 (PD-L1) and its receptor, programmed cell death protein 1 (PD-1), modulate anti-tumor immunity and are major targets of current checkpoint blocka...
Development of Best-in-Class Pol-Theta Inhibitors
Project summary. BRCA1 and BRCA2 facilitate DNA double-strand break (DSB) repair via homologous recombination (HR). Yet BRCA1/2 are often mutated in cancers, such as breast/ovarian...