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20,252 grants found
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Enhanced imaging and treatment of aggressive subtypes of prostate cancer
Targeting the prostate-specific membrane antigen (PSMA) with small molecules for imaging and therapy of prostate cancer (PC) has revitalized the field of nuclear medicine. Few targ...
The role of CCR6 in Pancreatic Cancer and Tregs
PROJECT SUMMARY Pancreatic cancer has a dismal average life expectancy of around six months, in large part due to the marked immunosuppression surrounding the tumor preventing an a...
Optimizing TCR-CD3 signaling for immunotherapy of cancer
ABSTRACT The recent development of T cell-based cancer immunotherapies, including checkpoint blockade (anti-PD-1, anti-CTLA-4 and others) or adoptive T cell therapy (ACT) using mod...
Uncovering Oncogenotype-specific Vulnerabilities in Lung cancer
PROJECT SUMMARY Given the important roles of tumor suppressors and oncogenes in metabolic reprogramming, there is significant translational potential in identifying and understandi...
Elacestrant in breast cancer bone metastases
PROJECT SUMMARY Estrogen receptor (ER) signaling is the main driver of tumorigenesis in ER+ breast cancers by inducing proliferation and survival through genomic and non-genomic me...
The Midwest Tumor Microenvironment Meeting
PROJECT SUMMARY We request partial funding for the Midwest Tumor Microenvironment Meeting to be held at the University of Wisconsin-Madison Pyle Center in Madison, WI on May 20-22,...
Posttranslational modifications of glucocorticoid receptor associated with drug-resistance in prostate cancer
PROJECT SUMMARY (ABSTRACT) An evolving concept that contributes to our understanding of resistance to androgen deprivation therapy (ADT) or androgen receptor (AR) antagonists in ad...
Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability
PROJECT SUMMARY/ABSTRACT Cancer evolution driven by DNA-mutating APOBEC enzymes (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like), and the emergence of resistance...
Investigating the role of G-protein coupled estrogen receptor expression on cancer associated fibroblasts in therapy resistant ER+ breast cancer progression
Project Summary/Abstract Estrogen receptor positive (ER+) breast cancer (BC) accounts for the majority of all diagnosed BC for women in the United States. While traditional antihor...
BCOR/PRC1.1 Inactivation In Splicing Factor Mutant MDS Progression
PROJECT SUMMARY: Myeloid malignancy is characterized by the acquisition of mutations in a stereotyped order with distinct patterns of cooperating mutations. Mutations in genes that...
Disentangling the effect of Black/African Ancestry from confounding variables on colorectal cancer biology
SUMMARY There is a higher incidence and mortality of colorectal cancer (CRC) in individuals self-identifying as Black race compared to all other races and ethnicities in the US. Pr...
Mechanism and therapeutic targeting of abnormal androgenesis in CHD1-deficient prostate cancer
PROJECT SUMMARY Androgen receptor (AR) signaling is a major driver of prostate cancer (PCa) progression. Persistent activation of AR due to aberrant intratumoral androgen synthesis...
Clinical and pre-clinical investigation of extracellular vesicles as a mechanism of toxicity in the bladder of prostate cancer patients treated with radiotherapy
We propose to study extracellular vesicles (EVs) as novel mediators of the pathogenesis of radiation cystitis (RC), which affects approximately 15% of prostate cancer (PCa) patient...
SPECTRUM (Studying PRIDE to Enhance Cancer screening guidelines for TRansgender Users of gender-affirMing hormones)
SUMMARY Transgender (TG) men (assigned female at birth) and TG women (assigned male at birth) comprise a vulnerable population whose health is largely understudied. Approximately 7...
Impact of Cancer on Cognitive Trajectories in Older Adults
PROJECT SUMMARY Cancer-related cognitive impairment (CRCI) represents an important clinical issue affecting up to 75% of people before, during, and after diagnosis and treatment. U...
Roles of gut-breast axis in breast pathophysiology
Microbiome impacts cancer development and therapeutic efficacy. In addition to the guts, microbes reside in different tissues influencing the pathophysiology of the tissue microenv...
TROP2-Directed CAR-NK Cells for the Immunotherapy of Pancreatic Cancer
SUMMARY/ ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate of only ~12%. Therefore, there is a critical unmet need for new treatm...
Understanding patient-surgeon interactions to support deimplementation of preference-sensitive low value care
Project Summary/Abstract Breast surgeons have been highly successful at deimplementing some low-value surgical care but less successful at deimplementing care that is preference-se...
Targeting hTERT/telomerase for managing acquired resistance to third generation EGFR-TKIs in lung cancer
SUMMARY The ability of cancer cells to acquire resistance to anticancer drugs, resulting in eventual treatment failure, is one of the most challenging problems in cancer therapy. O...
Novel approaches to target KEAP1 mutant tumors
PROJECT SUMMARY/ABSTRACT Treating KRAS mutant lung adenocarcinoma (LUAD) remains a major challenge for clinical oncology. Approximately 20% of KRAS mutant LUAD tumors carry loss-of...