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20,252 grants found
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Imaging tumor-associated macrophages in head and neck squamous cell carcinoma using fluorine-19 MRI
In this project, we aim to translate a fluorine-19 (19F) MRI technology to visualize the tumor associated macrophage (TAM) burden in patients with recurrent head and neck squamous...
Leveraging Biologically Specific PET/MRI Monitoring and Therapeutic Modulation of the Hypoxic Glioblastoma Tumor Immune Microenvironment into Improved Outcomes
ABSTRACT Leveraging neuroinflammation to improve treatment outcomes for patients with glioblastoma is challenging because the hypoxic tumor immune microenvironment (TIME), mostly c...
Response assessment of glioblastoma using magnetic resonance elastography
PROJECT SUMMARY / ABSTRACT Glioblastoma (GBM) is the most aggressive and inevitably recurrent brain tumor with a dismal prognosis and highly heterogeneous profiles. While front-lin...
A New Strategy for Screening Effective Therapies for Metastatic Wilms Tumors
PROJECT SUMMARY Wilms tumor (WT) is the second most common solid pediatric cancer that usually develops in young children before age 5. WT encompass three main cell types: epitheli...
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver Tumors
PROJECT SUMMARY The overall goal of this proposal is to improve histotripsy treatments of liver tumors by developing an accurate, clinically translatable workflow for targeting liv...
Noninvasive assessment of IDH mutation status in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver malignancy in the United States and worldwide. iCCA has a dismal prognosis, with just a 20% 5-year su...
Childhood Cancer Survivor Study/Children's Oncology Group Late Effects Assessment Protocol
ABSTRACT The Childhood Cancer Survivor Study (CCSS; U24 CA055727; PI: Armstrong) is a multi-institutional, multi- disciplinary collaborative research resource established to system...
Bio statistics Core
PROJECT SUMMARY The Biostatistics and Computational Biology Core will provide comprehensive statistical, bioinformatics and computational biology support for all three projects and...
PDX Modeling Core
PROJECT SUMMARY: CORE 3 – PRECLINICAL MODELING The Preclinical Modeling Core will be co-led by Dr. Joyce Liu, a medical oncologist specializing in gynecologic cancers who has exper...
The COVID-19 and Cancer Consortium (CCC19) Registry
Project Summary People with cancer have a higher risk of infections in general because of vulnerabilities arising from their cancer and its treatments. This is especially true for...
Partnerships to Reduce Obesity in Community Health Center Patients
PROJECT SUMMARY/ABSTRACT Approximately 40% of U.S. adults have obesity (BMI>30), and excess body weight is associated with at least 13 different cancers and 5% and 11% of cancer...
Mechanical Stress and Lung Tumor Progression
PROJECT SUMMARY Lung cancer is the #1 cause of cancer death in the US. The 5-year rate of cancer recurrence and death remains high, even for patients with early tumors. An incomple...
Characterization of NUP205 as a haploinsufficient essential gene for the treatment of hematopoietic malignancies
PROJECT SUMMARY/ABSTRACT Complete or partial loss of chromosome 7 (-7/del(7q)) predisposition syndromes, preleukemia, and leukemia. is the most common cytogenetic abnormality in It...
Novel strategies to improve mesothelioma therapy
PROJECT SUMMARY Exposure to asbestos fibers is the major risk factor for the development of malignant mesothelioma (MM). We demonstrated that asbestos fibers induce HMGB1 transloca...
Targeting pancreatic cancer metastases with Targefrin
ABSTRACT We intend to devise a novel therapeutic strategy based on a specific cancer cell receptor named EphA2, which is abundant on the surface of metastatic pancreatic cancers. O...
Investigating the MAIT cell- Microbiome Relationship in Pancreatic Cancer Liver Metastasis
Project Summary/Abstract Pancreatic cancer liver metastasis (PCLM) is present in 50% of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) and has a median survival of
Proteomic signatures to predict drug response in cancer
Abstract Precision medicine in oncology requires accurate prediction of drug response to guide personalized treatment decisions. We developed a pharmacoproteomics platform that lin...
Risk-stratified care for thyroid cancer survivors
Project Summary There has been an increase in the number of thyroid cancer survivors due to the rise in thyroid cancer incidence and young age at diagnosis. Although a substantial...
Mechanistic studies of the NRF2-Methylosome interaction in lung cancer.
ABSTRACT Lung cancer (LC) is the leading cause of cancer death, making up nearly 25% of all cancer deaths. Although some advances in personalized treatments have improved survival...
Proteolysis targeting chimera against nuclear receptor NR4A1 for melanoma therapy
Project Summary-Abstract Tumor microenvironment (TME) consists of many cell types that co-exist to promote tumor progression. Most cancer therapeutics are designed to target one mo...