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20,252 grants found
Showing 121 – 140 of 20,252 grants
Immunogenomics platform for the analysis of cancer
ABSTRACT The goal of this proposal is to provide support for my main roles as a Laboratory-based Research Specialist in my Unit Director Dr. Timothy Chan’s research program and as...
Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere
Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere The Meyer Cancer Center (MCC) of...
Enhanced Delivery of Cytotoxic Neural Stem Cells for Treatment of Glioblastoma Multiforme Using an Innovative In-situ Thermogelling Hydrogel and Focused Ultrasound
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer and ~90% of GBM patients die within 24 months after diagnosis.1 Treatment options for GBM...
Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54
PROJECT SUMMARY Colorectal cancer (CRC) is the third leading cause of cancer death in Black men and women, with mortality rates that are 44% and 31% higher in Black men and women c...
Discovering the mechanisms underlying oncogenesis by ZFTA-RELA and pinpointing therapeutic targets.
PROJECT SUMMARY: Ependymoma (EPN) is an aggressive and chemo-resistant pediatric brain tumor, with treatment remaining surgery and radiation. There are no targeted therapies availa...
Prospective validation of a radiomics-based multi-modal predictive model for metastatic non-small cell lung cancer patients treated with PD-1 immunotherapy
Summary PD-(L)1 checkpoint inhibitors are an effective class of oncology therapeutics, where some patients with non-small cell lung, bladder cancer and melanoma demonstrate durable...
Next Generation GPC2-CARs for Medulloblastoma
Project Summary Progress against pediatric solid tumors has stalled. Current standard therapies largely employ dose intensive cytotoxic agents developed in the 1970s and 1980s that...
Radiomic biomarkers for clinical decision support that predict patient outcomes in serous ovarian carcinoma
ABSTRACT Less than a third of women diagnosed with advanced epithelial ovarian cancer (EOC) survive five years after diagnosis. Despite therapeutic improvements over time, patient...
Building Stochastic Actor-Oriented Models to investigate social network influences on youth nicotine product use transitions and to simulate different intervention effects across contexts
PROJECT SUMMARY In the United States, Mexico, and in many countries around the world, teens’ combustible cigarette (CCs) use has declined in recent years, yet that progress is thre...
Multi-omic liquid biopsy assessment in NCI trials: evaluating ctDNA, extravesicle RNA, and outcomes with immunotherapy in patient with colorectal and anal cancers
My long term goal as a clinical scientist at MD Anderson Cancer Center is to lead clinical trials that improve survival for patients with gastrointestinal malignancies, particularl...
Overcoming treatment-resistant gynecological cancers by combination of DNA damage response inhibitors
Project Summary About 50% of high grade serous ovarian cancers (HGSOC) exhibit defects in homologous recombination (HR; e.g. BRCA1/2 mutations). Approximately 20% HGSOC and 50% of...
Mechanisms of S100A9-mediated brain metastasis
Approximately 50% of patients with EGFR-mutant lung cancer develop brain metastasis (BM), which is associated with poor prognosis and accelerated mortality. There is a long-term un...
Return-to-work issues in healthcare workers diagnosed with cancer: Investigation and Intervention Development
Project Summary/Abstract Nurses are the largest healthcare sector, with approximately 5.2 million active licenses in the United States. However, nurses encounter occupational hazar...
Methods for characterizing mechanobiology of the tumor microenvironment landscape
Cells within the tissue microenvironment sense, process and respond to mechanical cues from their environment. This mechanosensing is essential for tissue homeostasis, and its dysr...
Orphan Non-coding RNA-based Test for Detecting Minimal Residual Disease in Resectable Non-small Cell Lung Cancer
The early detection of non-small cell lung cancer (NSCLC) is an unmet challenge in the field with significant direct impact on effectiveness of treatments and survival rate of affe...
Fibrinogen-coated albumin nanospheres for mitigation of irradiation-induced wound healing impairment in breast cancer patients.
PROJECT SUMMARY Impaired wound healing after radiation therapy is a major clinical challenge in the management of oncologic patients. The efficacy of radiotherapy in cancer treatme...
Topic Number 431Cancer Treatment Technologies for Low-Resource Settings
Fluorescent guided surgery is receiving increased attention for cancer treatment. Fluorescent dyes aid identification of cancerous cells that can be missed by the naked eye.A laser...
TOPIC NUMBER: 464 SBIR PHASE ICLOUD-BASED MULTIMODAL DATA ANALYSIS SOFTWARE FOR THE CANCER RESEARCH DATA COMMONS
Clinical Data (MAGIC) within the Cancer Research Data Commons (CRDC).It leverages extensive expertise in Natural Language Processing (NLP) for clinical narrative analysis and deep...
WISDOM: A platform to optimize subtype-specific screening and prevention
The WISDOM Study, that includes 45,000 women in the US, is the first large-scale study of a risk-based approach to breast cancer screening. Its goal is to determine if risk-based s...
Developing, Implementing and Supporting NCI Clinical Trials and the National Cancer Trials Network (NCTN) in Breast Cancer and Developmental Therapeutics- A 5 Year Plan
Project Summary/Abstract Dr. Ciara O’Sullivan is a medical oncologist focusing on clinical and translational research in breast cancer (BC) and developmental therapeutics. Her rese...