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20,252 grants found
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Pathology Core
PROJECT SUMMARY/ABSTRACT The Pathology Core will be co-led by Dr. Marisa Nucci, a pathologist with expertise in gynecologic neoplasia, and by Dr. Geoffrey Shapiro, who brings exper...
Mapping ductal carcinoma in situ in space and time to reveal biomarkers that can predict invasive risk
ABSTRACT Each year, 50.000 women are diagnosed with ductal carcinoma in situ (DCIS) in the US. DCIS is a non-invasive form of breast cancer, which respects the natural tissue barri...
Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection
Abstract Ovarian cancer remains the most lethal gynecological malignancy due to the lack of highly sensitive and specific screening tools for detection of early-stage disease. The...
Body composition and adiposity-associated thromboinflammation in colorectal cancer prognosis
SUMMARY Obesity increases the risk of numerous cancers including colorectal cancer (CRC). With the growing global epidemic of obesity, a greater understanding of the obesity cancer...
Regulation of RBP Function during EMT
The goal of this research is to characterize Ras-driven and KSR1-dependent mechanisms that modulate tumor initiation, drug resistance and the epithelial-to-mesenchymal transition (...
Bioreactor for Manufacturing Chemotactically Competent Immune Cell Therapies
PROJECT SUMMARY Current cell expansion procedures for antigen-specific CAR T cells and CAR NK cells result in cells with a broad repertoire of chemokine receptors. Upon infusion, t...
Development of IFNA2-LNP01 for tumor lung metastases immunotherapy
Project Summary Lung metastasis is the 2nd most common metastasis and accounts for 30% of all metastatic diseases in human cancer patients. Patients with lung metastases have a ver...
Chromosomal Instability and 17p Loss Sensitize Cancer Cells to NDE1 Depletion
PROJECT SUMMARY Chromosomal Instability (CIN) and loss of the short arm of chromosome 17 (17p) are interrelated and relatively common characteristics of many advanced, metastatic c...
Engager T cell: A Simple Solution for Off-the-shelf T Cell Therapy for Cancer
Project Summary Autologous chimeric antigen receptor T (CAR T) cell therapy poses logistical and economical challenges despite curative potential. Donor-derived allogeneic off-the-...
A novel MICA/B based tumor-centric bispecific antibody that enhances NK cell activity in a hostile tumor microenvironment
PROJECT SUMMARY/ABSTRACT Problem: Lung cancer is the third most common cancer in the US, with an estimated 238,340 new cases in 2023, and is projected to be about 2.5 times more de...
High throughput CAR-T potency assay based on functional and transcriptional measurements on single cell co-cultures
ABSTRACT Over the last decade, cell based “living medicines” like chimeric antigen receptor (CAR)-T cell immunotherapies have led to miraculous cures in advanced and aggressive leu...
Computer Guided Microwave Liver Ablation
Project Summary: The primary objective of this proposed research program is to evaluate in a clinical trial the improvements to clinical outcomes that the use of a software for sup...
Defining the functional and spatial properties of tumor-specific tumor-infiltrating CD8 T cells
Project Summary/Abstract Successful anti-tumor immune response requires coordination between the arms of immunity against multiple tumor antigens, as shown through studies of anima...
Predicting prostate cancer clinical outcomes with germline genomic biomarkers
PROJECT SUMMARY/ABSTRACT Prostate cancer is the second-most diagnosed cancer and the second leading cause of cancer death in American men. Early detection of localized disease is c...
Accurate interaction detection in combinatorial screens with complex phenotypes
Project Summary Combinatorial screens characterize the molecular pathways of the cell by identifying interactions between perturbations. Quantifying interactions requires a notion...
Targeting WEE1 in uterine serous or p53-mutated uterine cancer
PROJECT SUMMARY/ABSTRACT: PROJECT 1 – WEE1 inhibition in uterine serous carcinomas or p53-mutated uterine cancers Uterine serous carcinomas (USC) are a distinct histologic subtype...
Targeting replication stress to engage DNA sensing STING pathway derived anti-tumor immunity to improve the therapeutic outcomes in uterine cancer
Project Summary Microsatellite stable (MSS)/mismatch repair proficient (MMRP) uterine cancers (UCs) represent approximately two thirds (66%) of all UCs in The Cancer Genome Atlas (...
Administrative Core
Project Summary The Administrative Core is led by Drs. Panagiotis Konstantinopoulos, Joyce Liu, and Ursula Matulonis who are in addition the Principal Investigators (PI)/Program Di...
Dissecting roles of Lunatic Fringe-dependent Notch signaling in pancreatic cancer
Despite improvements in overall survival for most cancers, survival for patients with pancreatic cancer remains dismally low due to the late diagnosis and rapid spreading. Understa...
Trajectory of epigenetic aging and health outcomes in childhood cancer survivors
ABSTRACT Survivors of childhood cancer are at increased risk for chronic health conditions (CHCs) and early mortality at rates typically among individuals decades older, suggesting...